Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy DOI Creative Commons

Zheng Cheng,

Yuchen Wang,

Haobo Lin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis the jaw (ORNJ) after radiotherapy. Various radiation-induced tissue injuries are associated reactive oxygen nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO

Language: Английский

Investigation into recent advanced strategies of reactive oxygen species-mediated therapy based on Prussian blue: Conceptualization and prospect DOI
Hee Young Kwon, Yuna Jung, Hojeong Jeon

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 71 - 99

Published: Feb. 13, 2025

Language: Английский

Citations

1
Research progress on the synthesis, performance regulation, and applications of Prussian blue nanozymes DOI
Yiyang Wang, Lei Gao, Yue Cao

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 295, P. 139535 - 139535

Published: Jan. 5, 2025

Language: Английский

Citations

0
Intra-articular injection of MOF-based nanomaterials for the treatment of osteoarthritis by modulating the bone microenvironment DOI Creative Commons
Bing Tan, Yuhao Zheng, Jie Hao

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 17, 2025

Language: Английский

Citations

0
Regulator of oxidative balance: Research progress of nanozymes in ROS-related diseases DOI
Xiang Wang, Zidong Wang, Siyuan Hu

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102540 - 102540

Published: Jan. 22, 2025

Language: Английский

Citations

0
Intelligent Nanomaterials Design for Osteoarthritis Managements DOI Open Access
Zhihao Chen, Xuan Zheng, Zhengzhi Mu

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Language: Английский

Citations

0
Inflammatory Targeted Nanoplatform Incorporated with Antioxidative Nano Iron Oxide to Attenuate Ulcerative Colitis Progression DOI Creative Commons
Haojun Chen, Wei Sun, Can Li

et al.

iScience, Journal Year: 2025, Volume and Issue: unknown, P. 112448 - 112448

Published: April 1, 2025

Antioxidative nanomaterials with reactive oxygen species (ROS) scavenging capabilities hold promise for the treatment of ulcerative colitis (UC). However, their clinical application is limited by rapid diffusion, susceptibility to inactivation, and insufficient targeting inflammatory sites. This study focuses on developing a nanoplatform integrating iron oxide nanoparticles (IONPs) into zeolitic imidazolate frameworks-8 (ZIF-8), termed as ZIF-8@IONPs. ZIF-8@IONPs exhibited good biocompatibility effective ROS in RAW 264.7 cells. To enhance targeting, HA@ZIF-8@IONPs were generated through hyaluronic acid (HA) surface modification. effectively reduced damage intestinal tissues UC mouse model. Mechanistic revealed that antioxidant anti-inflammatory activities eliminating endogenous ROS, activating Nrf2 signaling pathway, inhibiting NF-κB pathway. highlights nanoplatform's potential promising candidate due its great microenvironments efficient scavenging.

Language: Английский

Citations

0
Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing via ferroptosis inhibition DOI Creative Commons
Qingrong Dong, Xiaomei Shen, Fang Ge

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101839 - 101839

Published: May 1, 2025

Language: Английский

Citations

0
Microfluidic-engineering Prussian blue hydrogel microspheres for enhanced osteoarthritis antioxidant therapy DOI
W. Peng, Jie Lan,

MeeiChyn Goh

et al.

Biomaterials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 214345 - 214345

Published: May 1, 2025

Language: Английский

Citations

0
Prussian blue nanoparticles mitigate inflammatory osteolysis by reducing oxidative stress and enhancing endogenous antioxidant systems DOI

Wenjia Wei,

Yucheng Wang, Guangxin Sun

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 254, P. 114806 - 114806

Published: May 17, 2025

Language: Английский

Citations

0
Engineering Dual Active Sites and Defect Structure in Nanozymes to Reprogram Jawbone Microenvironment for Osteoradionecrosis Therapy DOI Creative Commons

Zheng Cheng,

Yuchen Wang,

Haobo Lin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Four to eight percent of patients with head and neck cancer will develop osteoradionecrosis the jaw (ORNJ) after radiotherapy. Various radiation-induced tissue injuries are associated reactive oxygen nitrogen species (RONS) overproduction. Herein, Fe doping is used in VO

Language: Английский

Citations

1