ROS‐Modulating Bio‐Heterojunction Nanosheets for Infected Wound Healing via Nanozyme Activity

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Reactive oxygen species (ROS) play a pivotal role in wound healing due to their ability eradicate bacterial infections. However, excessive ROS can induce oxidative stress and prolonged inflammation, which significantly hinder the wound‐healing process. To address this challenge, Ti 3 C 2 T x ‐Se NPs (TS) heterojunction nanosheets, are developed enhance electron transfer under near‐infrared (NIR) laser irradiation confirmed by ultraviolet photoelectron spectroscopy (UPS) analysis. Compared , TS exhibits superior antibacterial activity against S. aureus E. coli through synergistic mechanisms of chemical dynamic therapy (CDT) photothermal (PTT). In absence treatment, demonstrates “ROS modulating effect”, effectively scavenging catalase (CAT) superoxide dismutase (SOD) activities. efficiently eliminated hydroxyl radicals (90.87%), anion (76.33%), hydrogen peroxide (95.72%) at low concentration, thereby minimizing damage. vivo studies further reveal that reduces damage, clears infections, promotes angiogenesis, accelerating healing. offers precise regulation while leveraging effects PTT CDT. This material not only potent properties but also alleviates accumulation, mitigates fosters tissue regeneration, making it promising candidate for treatment infectious wounds.

Language: Английский

Construction of CeO2/Ti3C2Tx heterojunction with antibacterial and antioxidant capabilities for diabetic wound healing

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137247 - 137247

Published: March 4, 2025

Language: Английский

MXene/Carbon Dot Nanocomposites with Photothermal/Physical Synergistic Antibacterial Capability for Wound Healing

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский