Polymer-Based Raman/PET Dual-Modal Probe for Preoperative Tumor Diagnosis and Intraoperative Image-Guided Surgery and Phototherapy DOI
Yuanyuan Qiu, Qi Zhu, Kai Cui

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Integration of Raman imaging and positron emission tomography (PET) holds great promise for providing complementary information precise cancer diagnosis imaging-guided therapy. However, current existing Raman/PET dual-modal probes primarily rely on surface-enhanced scattering, raising clinical concerns about the biosafety substrates. Herein, we developed a novel substrate-free probe-[18F]-AS-DPPT-TT NPs, which integrates biocompatible polymer DPPT-TT that possesses strong signals photothermal effects, along with radiolabeling by short-lived 18F radionuclide functionalization tumor-targeting AS1411 aptamer. The [18F]-AS-DPPT-TT NPs generate ultrasensitive resonance under 785 nm excitation, due to their absorption peak closely matching excitation light, exhibit significant effects tumor cell ablation 808 excitation. In orthotopic colon mouse models, enabled preoperative PET high-contrast whole-body localization simultaneously provided intraoperative accurate boundary delineation micrometastasis detection (as small as 0.58 mm × 0.32 mm). Moreover, surgery combined therapy achieved complete elimination primary metastatic tumors, significantly decreasing recurrence rates. This probe effectively combines strengths imaging, robust platform comprehensive management from planning intervention.

Language: Английский

A Lanthanide Nanoparticle–Aggregation-Induced Emission Photosensitizer Complex System Drives Coupled Triplet Energy Transfer for Enhanced Radio-Photodynamic Therapy DOI

Yibo An,

Dazhuang Xu,

Pan He

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Cerenkov light (CL), utilized as an internal excitation source for photodynamic therapy (PDT), addresses the limitations of laser penetration and has substantial potential seamlessly integrating clinical radiotheranostics with phototheranostics. Nevertheless, effectiveness CL-mediated PDT is significantly hindered by challenges, such low intensity CL inadequate energy transfer between donor photosensitizers (PSs). In this study, a novel approach introduced enhanced radionuclide-activated radio-photodynamic utilizing hybrid nanoparticle system composed lanthanide nanoparticles aggregation-induced emission photosensitizer (AIE PS), designated LnNP–TQ NPs. This enables to optimize decay radionuclides, effectively sensitizing AIE PS through triplet (TET)-mediated processes efficiency approaching 100%. When activated radionuclide 18F positron tomography imaging, NPs substantially inhibited tumor growth via effective singlet oxygen (1O2) generation. strategy, which optimally harnesses achieves efficient transfer, offers promising pathway enhancing radiotherapy–phototherapy efficacy in treatment.

Language: Английский

Citations

1
Polymer-Based Raman/PET Dual-Modal Probe for Preoperative Tumor Diagnosis and Intraoperative Image-Guided Surgery and Phototherapy DOI
Yuanyuan Qiu, Qi Zhu, Kai Cui

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 13, 2025

Integration of Raman imaging and positron emission tomography (PET) holds great promise for providing complementary information precise cancer diagnosis imaging-guided therapy. However, current existing Raman/PET dual-modal probes primarily rely on surface-enhanced scattering, raising clinical concerns about the biosafety substrates. Herein, we developed a novel substrate-free probe-[18F]-AS-DPPT-TT NPs, which integrates biocompatible polymer DPPT-TT that possesses strong signals photothermal effects, along with radiolabeling by short-lived 18F radionuclide functionalization tumor-targeting AS1411 aptamer. The [18F]-AS-DPPT-TT NPs generate ultrasensitive resonance under 785 nm excitation, due to their absorption peak closely matching excitation light, exhibit significant effects tumor cell ablation 808 excitation. In orthotopic colon mouse models, enabled preoperative PET high-contrast whole-body localization simultaneously provided intraoperative accurate boundary delineation micrometastasis detection (as small as 0.58 mm × 0.32 mm). Moreover, surgery combined therapy achieved complete elimination primary metastatic tumors, significantly decreasing recurrence rates. This probe effectively combines strengths imaging, robust platform comprehensive management from planning intervention.

Language: Английский

Citations

0