Targeting drug cocktail hydrogel platform for inhibiting tumor growth and metastasis DOI Creative Commons

Liying Xiao,

Jianwen Hou,

Hongxiang Liu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101798 - 101798

Published: April 23, 2025

The combination therapy could overcome the limitation of monotherapy to inhibit tumor recurrence and metastasis, but is usually constrained by complex fabrication processes. Here, a tunable hydrogel platform was developed using different silk nanocarriers, which independently achieve flexible functional optimization various drugs. Silk nanorods (SNR) were modified with cRGDfK peptides targeting ability vessels then loaded hydrophobic vascular inhibitor Combretastatin A4 (CA4). loading CA4 targeted modification be tuned enhance destruction vessels. Both hydrophilic doxorubicin (DOX) paclitaxel (PTX) co-loaded on nanofibers (SNF) form injectable hydrogels optimized chemotherapy. drug-laden SNR SNF blended directly without compromise drug biological activity. co-delivery DOX PTX improved therapeutic efficiency in vitro vivo. long-term inhibition metastasis achieved through are superior previous chemotherapy systems PTX. gradual modular process simple physical blending endowed high flexibility tunability, suggesting suitable for designing cocktail system.

Language: Английский

Targeting drug cocktail hydrogel platform for inhibiting tumor growth and metastasis DOI Creative Commons

Liying Xiao,

Jianwen Hou,

Hongxiang Liu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101798 - 101798

Published: April 23, 2025

The combination therapy could overcome the limitation of monotherapy to inhibit tumor recurrence and metastasis, but is usually constrained by complex fabrication processes. Here, a tunable hydrogel platform was developed using different silk nanocarriers, which independently achieve flexible functional optimization various drugs. Silk nanorods (SNR) were modified with cRGDfK peptides targeting ability vessels then loaded hydrophobic vascular inhibitor Combretastatin A4 (CA4). loading CA4 targeted modification be tuned enhance destruction vessels. Both hydrophilic doxorubicin (DOX) paclitaxel (PTX) co-loaded on nanofibers (SNF) form injectable hydrogels optimized chemotherapy. drug-laden SNR SNF blended directly without compromise drug biological activity. co-delivery DOX PTX improved therapeutic efficiency in vitro vivo. long-term inhibition metastasis achieved through are superior previous chemotherapy systems PTX. gradual modular process simple physical blending endowed high flexibility tunability, suggesting suitable for designing cocktail system.

Language: Английский

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