Sequentially Releasing Aspirin and Osteogenic Growth Peptide Scaffold Modulates Immunity and Bone Homeostasis to Enhance Periodontal Bone Regeneration DOI

Xin Mu,

Yikun Yang,

Huachang Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Severe periodontitis, affecting 10% of the population, is characterized by chronic inflammation and bone loss. Given limitations current treatments, modulating enhancing regeneration from an immunological perspective represent a promising strategy. This study developed hierarchical drug delivery scaffold with outer layer poly(lactic-co-glycolic acid) loaded aspirin inner core poly(L-lactic containing osteogenic growth peptide (OGP), fabricated via electrospinning. In early implantation phase, suppresses M1 promotes macrophage M2 polarization, shifting periodontal microenvironment inflammatory to regenerative. At later stages, release OGP enhances at implant site. The sequentially releasing OGP-Scaffold (As+OGP-Scaffold) demonstrate excellent biocompatibility potent immuno-osteogenic effects both in vitro vivo. Bioinformatics Western blot analyses show that As+OGP-Scaffold modulates polarization inhibiting ERK-CREB axis activating STAT3 pathway while promoting osteogenesis through SMAD signaling pathways suppressing osteoclast-associated MAPK signaling. dual approach offers solution for severe periodontitis.

Language: Английский

Nanomaterial-based scaffolds for bone regeneration with piezoelectric properties DOI

Chandra Sekhar Kathera,

Zehra Çobandede,

Kaylea Titus

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: May 15, 2025

For proper cellular growth, to prepare tissue scaffold mimicking the properties is a significant challenge. Bone vital organ supporting whole human body for its function. The efficiencies in structure variety of reasons should properly be remedied. engineering (BTE) an emerging field addressing develop or repair bone naturally piezoelectric material and generates electrical stimuli because mechanical stress. Thus, use materials build great interest BTE. Both polymers nanomaterials (NMs) are investigated this goal. In review, we give overview recent advances NMs construct scaffolds

Language: Английский

Citations

0
Harnessing the Osteogenic Potential of Novel Copper Modified Baghdadite Nanogalleris Integrated in Silk Fibroin Electrospun Scaffolds for Enhanced Bone Regeneration DOI
Sanaz Khademolqorani, Seyedeh Nooshin Banitaba, Monireh Kouhi

et al.

Journal of Polymers and the Environment, Journal Year: 2025, Volume and Issue: unknown

Published: May 26, 2025

Language: Английский

Citations

0
Sequentially Releasing Aspirin and Osteogenic Growth Peptide Scaffold Modulates Immunity and Bone Homeostasis to Enhance Periodontal Bone Regeneration DOI

Xin Mu,

Yikun Yang,

Huachang Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: June 5, 2025

Severe periodontitis, affecting 10% of the population, is characterized by chronic inflammation and bone loss. Given limitations current treatments, modulating enhancing regeneration from an immunological perspective represent a promising strategy. This study developed hierarchical drug delivery scaffold with outer layer poly(lactic-co-glycolic acid) loaded aspirin inner core poly(L-lactic containing osteogenic growth peptide (OGP), fabricated via electrospinning. In early implantation phase, suppresses M1 promotes macrophage M2 polarization, shifting periodontal microenvironment inflammatory to regenerative. At later stages, release OGP enhances at implant site. The sequentially releasing OGP-Scaffold (As+OGP-Scaffold) demonstrate excellent biocompatibility potent immuno-osteogenic effects both in vitro vivo. Bioinformatics Western blot analyses show that As+OGP-Scaffold modulates polarization inhibiting ERK-CREB axis activating STAT3 pathway while promoting osteogenesis through SMAD signaling pathways suppressing osteoclast-associated MAPK signaling. dual approach offers solution for severe periodontitis.

Language: Английский

Citations

0