Nanomaterial-based scaffolds for bone regeneration with piezoelectric properties
Chandra Sekhar Kathera,
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Zehra Çobandede,
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Kaylea Titus
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et al.
Nanomedicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 17
Published: May 15, 2025
For
proper
cellular
growth,
to
prepare
tissue
scaffold
mimicking
the
properties
is
a
significant
challenge.
Bone
vital
organ
supporting
whole
human
body
for
its
function.
The
efficiencies
in
structure
variety
of
reasons
should
properly
be
remedied.
engineering
(BTE)
an
emerging
field
addressing
develop
or
repair
bone
naturally
piezoelectric
material
and
generates
electrical
stimuli
because
mechanical
stress.
Thus,
use
materials
build
great
interest
BTE.
Both
polymers
nanomaterials
(NMs)
are
investigated
this
goal.
In
review,
we
give
overview
recent
advances
NMs
construct
scaffolds
Language: Английский
Harnessing the Osteogenic Potential of Novel Copper Modified Baghdadite Nanogalleris Integrated in Silk Fibroin Electrospun Scaffolds for Enhanced Bone Regeneration
Journal of Polymers and the Environment,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 26, 2025
Language: Английский
Sequentially Releasing Aspirin and Osteogenic Growth Peptide Scaffold Modulates Immunity and Bone Homeostasis to Enhance Periodontal Bone Regeneration
Xin Mu,
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Yikun Yang,
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Huachang Zhang
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et al.
ACS Applied Materials & Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: June 5, 2025
Severe
periodontitis,
affecting
10%
of
the
population,
is
characterized
by
chronic
inflammation
and
bone
loss.
Given
limitations
current
treatments,
modulating
enhancing
regeneration
from
an
immunological
perspective
represent
a
promising
strategy.
This
study
developed
hierarchical
drug
delivery
scaffold
with
outer
layer
poly(lactic-co-glycolic
acid)
loaded
aspirin
inner
core
poly(L-lactic
containing
osteogenic
growth
peptide
(OGP),
fabricated
via
electrospinning.
In
early
implantation
phase,
suppresses
M1
promotes
macrophage
M2
polarization,
shifting
periodontal
microenvironment
inflammatory
to
regenerative.
At
later
stages,
release
OGP
enhances
at
implant
site.
The
sequentially
releasing
OGP-Scaffold
(As+OGP-Scaffold)
demonstrate
excellent
biocompatibility
potent
immuno-osteogenic
effects
both
in
vitro
vivo.
Bioinformatics
Western
blot
analyses
show
that
As+OGP-Scaffold
modulates
polarization
inhibiting
ERK-CREB
axis
activating
STAT3
pathway
while
promoting
osteogenesis
through
SMAD
signaling
pathways
suppressing
osteoclast-associated
MAPK
signaling.
dual
approach
offers
solution
for
severe
periodontitis.
Language: Английский