Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(29)
Published: Aug. 18, 2022
Abstract
Immunotherapy,
the
most
promising
strategy
of
cancer
treatment,
has
achieved
outcomes,
but
its
clinical
efficacy
in
pancreatic
is
limited
mainly
due
to
complicated
tumor
immunosuppressive
microenvironment.
As
a
highly
inflammatory
form
immunogenic
cell
death
(ICD),
pyroptosis
provides
great
opportunity
alleviate
immunosuppression
and
promote
systemic
immune
responses
solid
tumors.
Herein,
membrane‐targeted
photosensitizer
TBD‐3C
with
aggregation‐induced
emission
(AIE)
feature
trigger
pyroptosis‐aroused
immunotherapy
via
photodynamic
therapy
(PDT)
applied.
The
results
reveal
that
pyroptotic
cells
induced
by
could
stimulate
M1‐polarization
macrophages,
cause
maturation
dendritic
(DCs),
activation
CD8
+
cytotoxic
T‐lymphocytes
(CTLs).
Pyroptosis‐aroused
immunological
convert
“cold”
microenvironment
(TME)
“hot”
TME,
which
not
only
inhibits
primary
growth
also
attacks
distant
tumor.
This
work
establishes
platform
high
biocompatibility
for
light‐controlled
antitumor
immunity
aroused
pyroptosis.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: June 20, 2022
Abstract
In
recent
years,
immunotherapy
represented
by
immune
checkpoint
inhibitors
(ICIs)
has
led
to
unprecedented
breakthroughs
in
cancer
treatment.
However,
the
fact
that
many
tumors
respond
poorly
or
even
not
ICIs,
partly
caused
absence
of
tumor-infiltrating
lymphocytes
(TILs),
significantly
limits
application
ICIs.
Converting
these
“cold”
into
“hot”
may
ICIs
is
an
unsolved
question
immunotherapy.
Since
it
a
general
characteristic
cancers
resist
apoptosis,
induction
non-apoptotic
regulated
cell
death
(RCD)
emerging
as
new
treatment
strategy.
Recently,
several
studies
have
revealed
interaction
between
RCD
and
antitumor
immunity.
Specifically,
autophagy,
ferroptosis,
pyroptosis,
necroptosis
exhibit
synergistic
responses
while
possibly
exerting
inhibitory
effects
on
responses.
Thus,
targeted
therapies
(inducers
inhibitors)
against
combination
with
exert
potent
activity,
resistant
This
review
summarizes
multilevel
relationship
immunity
RCD,
including
necroptosis,
potential
targeting
improve
efficacy
malignancy.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Dec. 8, 2022
Abstract
Many
types
of
human
cells
self-destruct
to
maintain
biological
homeostasis
and
defend
the
body
against
pathogenic
substances.
This
process,
called
regulated
cell
death
(RCD),
is
important
for
various
activities,
including
clearance
aberrant
cells.
Thus,
RCD
pathways
represented
by
apoptosis
have
increased
in
importance
as
a
target
development
cancer
medications
recent
years.
However,
because
tumor
show
avoidance
apoptosis,
which
causes
treatment
resistance
recurrence,
numerous
studies
been
devoted
alternative
mortality
processes,
namely
necroptosis,
pyroptosis,
ferroptosis,
cuproptosis;
these
modalities
extensively
studied
shown
be
crucial
therapy
effectiveness.
Furthermore,
evidence
suggests
that
undergoing
may
alter
immunogenicity
microenvironment
(TME)
some
extent,
rendering
it
more
suitable
inhibiting
progression
metastasis.
In
addition,
other
components
TME
undergo
abovementioned
forms
induce
immune
attacks
on
cells,
resulting
enhanced
antitumor
responses.
Hence,
this
review
discusses
molecular
processes
features
cuproptosis
effects
novel
proliferation
Importantly,
introduces
complex
affect
biology.
It
also
summarizes
potential
agents
nanoparticles
or
inhibit
their
therapeutic
based
from
vivo
vitro
reports
clinical
trials
inducers
evaluated
treatments
patients.
Lastly,
we
summarized
impact
modulating
drug
advantages
adding
modulators
over
conventional
treatments.
Cell Death Discovery,
Journal Year:
2020,
Volume and Issue:
6(1)
Published: Oct. 28, 2020
Abstract
Apoptosis
has
long
been
recognized
as
a
mechanism
that
kills
the
cancer
cells
by
cytotoxic
drugs.
In
recent
years,
studies
have
proved
pyroptosis
can
also
shrink
tumors
and
inhibit
proliferation.
Both
apoptosis
are
caspase-dependent
programmed
cell
death
pathways.
Cysteinyl
aspartate
specific
proteinase-3
(Caspase-3)
is
common
key
protein
in
pathways,
when
activated,
expression
level
of
tumor
suppressor
gene
Gasdermin
E
(GSDME)
determines
death.
When
GSDME
highly
expressed,
active
caspase-3
cuts
it
releases
N-terminal
domain
to
punch
holes
membrane,
resulting
swelling,
rupture,
low,
will
lead
classical
death,
which
apoptosis.
More
interestingly,
researchers
found
be
located
upstream
caspase-3,
connecting
extrinsic,
intrinsic
apoptotic
Then,
promoting
activation,
forming
self-amplifying
feed-forward
loop.
GSDME-mediated
correlated
with
side
effects
chemotherapy
anti-tumor
immunity.
This
article
mainly
reviews
caspase-3/GSDME
signal
pathway
switch
between
cancer,
provide
new
strategies
targets
for
treatment.
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2021,
Volume and Issue:
40(1)
Published: May 3, 2021
Abstract
Background
Unraveling
the
mystery
of
cell
death
is
one
most
fundamental
progresses
life
sciences
during
past
decades.
Regulated
(RCD)
or
programmed
(PCD)
not
only
essential
in
embryonic
development,
but
also
plays
an
important
role
occurrence
and
progression
diseases,
especially
cancers.
Escaping
hallmarks
cancer.
Main
body
Pyroptosis
inflammatory
usually
caused
by
microbial
infection,
accompanied
activation
inflammasomes
maturation
pro-inflammatory
cytokines
interleukin-1β
(IL-1β)
interleukin-18
(IL-18).
Gasdermin
family
proteins
are
executors
pyroptosis.
Cytotoxic
N-terminal
gasdermins
generated
from
caspases
granzymes
proteases
mediated
cleavage
gasdermin
oligomerizes
forms
pore
across
membrane,
leading
to
release
IL-1β,
IL-18.
exerts
tumor
suppression
function
evokes
anti-tumor
immune
responses.
Therapeutic
regimens,
including
chemotherapy,
radiotherapy,
targeted
therapy
therapy,
induce
pyroptosis
cancer,
which
potentiate
local
systemic
immunity.
On
other
hand,
normal
cells
attributes
side
effects
anti-cancer
therapies.
Conclusion
In
this
review,
we
focus
on
regulatory
mechanisms
suppressive
We
discuss
attribution
reprogramming
microenvironments
restoration
immunity
its
potential
application
cancer
therapy.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(9), P. 4310 - 4329
Published: Jan. 1, 2022
Pyroptosis
is
a
lytic
and
inflammatory
type
of
programmed
cell
death
that
usually
triggered
by
inflammasomes
executed
gasdermin
proteins.
The
main
characteristics
pyroptosis
are
swelling,
membrane
perforation,
the
release
contents.
In
normal
physiology,
plays
critical
role
in
host
defense
against
pathogen
infection.
However,
excessive
may
cause
immoderate
continuous
responses
involves
occurrence
diseases.
Attractively,
as
immunogenic
death,
can
serve
new
strategy
for
cancer
elimination
inducing
pyroptotic
activating
intensely
antitumor
immunity.
To
make
good
use
this
double-edged
sword,
molecular
mechanisms,
therapeutic
implications
related
diseases
need
to
be
fully
elucidated.
review,
we
first
systematically
summarize
signaling
pathways
then
present
available
evidences
indicating
cancer.
Based
on
this,
focus
recent
progress
strategies
inhibit
treatment
diseases,
those
induce
therapy.
Overall,
should
shed
light
future
directions
provide
novel
ideas
using
powerful
tool
fight
