Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 27, 2023
Abstract
The
call
for
implementing
inhibitory
methods
in
cancer
treatment
has
intensified.
Recently,
deeply
affected
society,
with
Acute
Myeloid
Leukemia
(AML)
being
identified
as
one
of
the
most
formidable
and
lethal
adversaries.
This
research
investigates
intricate
interactions
between
vitamins
A,
B,
C,
D,
E,
K
critical
signaling
pathways,
such
NPM1,
FLT3,
RUNX1,
uncovering
meaningful
associations.
Employing
precision
molecular
docking
Autodock
Vina
1.5.7,
a
thorough
exploration
these
was
carried
out.
analysis
entailed
detailed
examination
hydrophilic
hydrophobic
aspects
using
LigPlot,
complemented
by
additional
insights
visualized
through
PyMol.
considerable
occurrence
observed
interactions,
coupled
noteworthy
binding
energy,
underscores
potential
vitamin-related
derivatives
promising
contenders
treatments.
However,
realization
this
is
contingent
upon
subsequent
investigations,
including
comprehensive
RT-qPCR
studies.
While
study
successfully
significant
dynamics
gene
expression
necessitate
studies
to
attain
holistic
understanding
both
upregulation
downregulation.
In
conclusion,
revelations
from
not
only
set
stage
treatments
AML
strategic
application
vitamin-based
but
also
underscore
transformative
capabilities
derivatives.
future
endeavors,
should
vitamin
reveal
substantial
downregulation,
stand
poised
spearhead
innovative
treatments,
marking
era
targeted
drug
delivery.
ACS electrochemistry.,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 17, 2025
Although
water
is
considered
detrimental
for
Li-ion
battery
technology,
a
1%
w/w
amount
of
in
melt
LiCl
ionic
liquid
1-butyl-3-methylimidazolium
chloride
promotes
the
reduction
lithium
into
LiAl
intermetallic
along
with
oxidation
to
O2
gas.
The
electrodeposition
an
layer
several
micrometers
thickness
demonstrated
by
combining
complementary
techniques,
such
as
galvanostatics,
X-ray
diffraction,
electron
energy-loss
spectroscopy,
mass
spectrometry,
and
1H
nuclear
magnetic
resonance.
concentration
found
be
critical
feature,
no
Li
deposited
when
dried.
Our
findings
highlight
innovative
simple
method
produce
using
chemical
reagents.
ACS Central Science,
Journal Year:
2024,
Volume and Issue:
10(8), P. 1460 - 1472
Published: Aug. 5, 2024
Photothermal
conversion
is
a
novel
heating
method
that
has
emerged
in
recent
years,
wherein
certain
species
can
convert
light
to
heat
with
great
efficiency.
These
photothermal
agents
have
shown
immense
promise
for
generating
nanoscale
thermal
gradients
under
mild,
visible
irradiation,
providing
pathway
combining
photochemistry
thermally
driven
reactivity.
While
this
mechanism
been
leveraged
effect
applications
such
as
therapeutics
and
steam
water
purification,
it
seen
limited
use
organic
synthesis.
This
outlook
explores
instances
the
was
used
directly
or
synergistic
component
drive
reactions
postulates
how
may
be
moving
forward.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(16), P. 8670 - 8670
Published: Aug. 8, 2024
Milk
thermal
treatment,
such
as
pasteurization,
high-temperature
short-time
processing,
and
the
emerging
ultra-short-time
processing
(<0.5
s),
are
crucial
for
ensuring
milk
safety
extending
its
shelf
life.
is
a
nutritive
food
matrix
with
various
macro/micro-nutrients
other
constituents
that
possibly
affected
by
treatment
reasons
associated
strength.
Therefore,
understanding
relationship
between
heating
strength
quality
vital
dairy
industry.
This
review
summarizes
impact
of
on
milk's
nutritional
sensory
properties,
synthesizing
structural
integrity
bioavailability
proteins,
profile
stability
fatty
acids,
retention
macro/micro-nutrients,
well
overall
flavor
profile.
Additionally,
it
examines
formation
heat-induced
markers,
Maillard
reaction
products,
lactulose,
furosine,
alkaline
phosphatase
activity,
which
serve
indicators
intensity.
Flavor
markers
commonly
used
to
assess
pasteurized
milk.
By
examining
former
studies,
we
conclude
ultra-short-time-processing-treated
comparable
in
terms
specific
parameters
(such
whey
protein
behavior,
ALP
contents).
aims
better
summarize
how
treatments
influence
matrix,
guiding
industry's
development
balancing
products'
value.
International Journal of Chemical Engineering,
Journal Year:
2025,
Volume and Issue:
2025(1)
Published: Jan. 1, 2025
This
study
investigates
the
isolation
of
commercial
isoprenol,
a
by‐product
large‐scale
isoprene
production.
The
challenge
lies
in
separating
isoprenol
from
an
azeotropic
mixture
with
4,4‐dimethyldioxane‐1,3.
separation
processes
considered
are
vacuum
and
extractive
distillation.
In
work,
experimental
studies
distillation
isoprenol‐4,4‐dimethyldioxane‐1,3
modeling
conditions
vapor‐liquid
phase
equilibrium
this
were
carried
out.
To
calculate
activity
coefficients
components,
UNIFAC
model
was
used.
Within
framework
model,
dimethyldioxane
molecule
divided
into
groups.
comparison
obtained
data
showed
adequacy
for
system
under
(the
error
component
concentrations
did
not
exceed
5%).
Modeling
that
azeotrope
point
is
sensitive
to
pressure
changes
completely
disappears
at
pressures
below
150
above
1100
mm·Hg.
Experiments
explored
effect
diethylene
glycol
as
agent
it
decreases
volatility
across
entire
concentration
range.
combination
allows
achieving
greater
effect,
coefficient
relative
value
α
12
=
0.415.
demonstrates
feasibility
by
methods,
yielding
commercial‐grade
isoprenol.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(49)
Published: Aug. 29, 2024
Abstract
30
Seconds
to
success!—The
Wittig
reaction,
a
fundamental
and
extensively
utilized
reaction
in
organic
chemistry,
enables
the
efficient
conversion
of
carbonyl
compounds
olefins
using
phosphonium
salts.
Traditionally,
meticulous
setup,
including
pre‐formation
reactive
ylide
species
via
deprotonation
salt,
is
crucial
for
achieving
high‐yielding
reactions
under
classical
solution‐based
conditions.
In
this
report,
we
present
an
unprecedented
protocol
ultra‐fast
mechanically
induced
solvent‐free
ambient
conditions,
often
eliminating
need
tedious
strict
air
moisture
exclusion.
A
range
aldehydes
ketones
were
reacted
with
diverse
salts
high‐energy
ball
milling
frequently
giving
access
respective
only
seconds.
