Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 27, 2023
Abstract
The
call
for
implementing
inhibitory
methods
in
cancer
treatment
has
intensified.
Recently,
deeply
affected
society,
with
Acute
Myeloid
Leukemia
(AML)
being
identified
as
one
of
the
most
formidable
and
lethal
adversaries.
This
research
investigates
intricate
interactions
between
vitamins
A,
B,
C,
D,
E,
K
critical
signaling
pathways,
such
NPM1,
FLT3,
RUNX1,
uncovering
meaningful
associations.
Employing
precision
molecular
docking
Autodock
Vina
1.5.7,
a
thorough
exploration
these
was
carried
out.
analysis
entailed
detailed
examination
hydrophilic
hydrophobic
aspects
using
LigPlot,
complemented
by
additional
insights
visualized
through
PyMol.
considerable
occurrence
observed
interactions,
coupled
noteworthy
binding
energy,
underscores
potential
vitamin-related
derivatives
promising
contenders
treatments.
However,
realization
this
is
contingent
upon
subsequent
investigations,
including
comprehensive
RT-qPCR
studies.
While
study
successfully
significant
dynamics
gene
expression
necessitate
studies
to
attain
holistic
understanding
both
upregulation
downregulation.
In
conclusion,
revelations
from
not
only
set
stage
treatments
AML
strategic
application
vitamin-based
but
also
underscore
transformative
capabilities
derivatives.
future
endeavors,
should
vitamin
reveal
substantial
downregulation,
stand
poised
spearhead
innovative
treatments,
marking
era
targeted
drug
delivery.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
24(2)
Published: Dec. 8, 2023
Abstract
Actual
problems
of
development
catalysts
for
hydrogenation
heterocyclic
compounds
by
hydrogen
are
summarized
and
discussed.
The
scope
review
covers
composites
nanoparticles
platinum
group
metals
3d
heterogeneous
catalytic
processes.
Such
include
increase
catalyst
activity,
which
is
important
reduction
precious
content;
new
systems
do
not
contain
or
cheaper
analogues
Pd;
control
factors
make
influence
on
the
selectivity
catalysts;
achievement
high
reproducibility
catalyst‘s
performance
quality
catalysts.
Own
results
authors
also
described.
were
prepared
decomposition
Pd
0
Ni
complexes,
pyrolysis
2+
Co
complexes
deposited
aerosil
in
pores
porous
support
situ
.
developed
used
multigram
batches
compounds.
30
Seconds
to
success!
–
The
Wittig
reaction,
a
fundamental
and
extensively
utilized
reaction
in
organic
chemistry,
enables
the
efficient
conversion
of
carbonyl
compounds
olefins
using
phosphonium
salts.
Traditionally,
meticulous
setup,
including
pre-formation
reactive
ylide
species
via
deprotonation
salt,
is
crucial
for
achieving
high-yielding
reactions
under
classical
solution-based
conditions.
In
this
report,
we
present
an
unprecedented
protocol
ultra-fast
mechanochemically
driven
solvent-free
ambient
conditions,
eliminating
need
tedious
strict
air
moisture
exclusion.
A
range
aldehydes
ketones
were
reacted
with
diverse
salts
high-speed
ball
milling
giving
access
respective
only
seconds.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(50)
Published: Aug. 26, 2024
Abstract
The
[2+2]
cycloaddition
reaction
between
the
Si=C
double
bond
of
adamantylsilene
and
carbonyl
group
aliphatic,
aromatic
or
acetylenic
ketones
aldehydes
is
demonstrated.
product
this
that
central
to
a
non‐ionic
version
Peterson
olefination
an
unusual
four‐membered
1,2‐silaoxetane
heterocycle
was
characterized
spectroscopically
crystallographically.
In
presence
SiO
2
,
silaoxetane
undergoes
retro‐cycloaddition
with
formation
alkene
products.
As
proceeds
without
necessity
any
base,
enolizable
can
be
converted
into
olefins.
addition,
it
shown
produced
in
situ
by
sila‐Peterson
reaction,
providing
valuable
input
for
development
new
one‐pot
silicon‐based
reductive
carbonyl‐carbonyl
cross
coupling
methodology.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(50)
Published: Aug. 26, 2024
Abstract
The
[2+2]
cycloaddition
reaction
between
the
Si=C
double
bond
of
adamantylsilene
and
carbonyl
group
aliphatic,
aromatic
or
acetylenic
ketones
aldehydes
is
demonstrated.
product
this
that
central
to
a
non‐ionic
version
Peterson
olefination
an
unusual
four‐membered
1,2‐silaoxetane
heterocycle
was
characterized
spectroscopically
crystallographically.
In
presence
SiO
2
,
silaoxetane
undergoes
retro‐cycloaddition
with
formation
alkene
products.
As
proceeds
without
necessity
any
base,
enolizable
can
be
converted
into
olefins.
addition,
it
shown
produced
in
situ
by
sila‐Peterson
reaction,
providing
valuable
input
for
development
new
one‐pot
silicon‐based
reductive
carbonyl‐carbonyl
cross
coupling
methodology.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(49)
Published: Aug. 29, 2024
Abstract
30
Sekunden
zum
Erfolg!
–
Die
Wittig‐Reaktion,
eine
grundlegende
und
weit
verbreitete
Reaktion
in
der
organischen
Synthesechemie,
ermöglicht
die
effiziente
Umwandlung
von
Carbonylverbindungen
zu
den
entsprechenden
Olefinen
unter
Verwendung
Phosphoniumsalzen.
Traditionell
ist
ein
sorgfältiger
Reaktionsaufbau,
einschließlich
vorangestellten
Bildung
einer
reaktiven
Ylid‐Spezies
durch
Deprotonierung
eines
Phosphoniumsalzes,
entscheidend,
um
hohe
Ausbeuten
klassischen,
lösungsmittelbasierten
Bedingungen
erzielen.
In
diesem
Bericht
stellen
wir
noch
nie
dagewesenes
Protokoll
für
ultraschnelle
mechanisch
induzierte
Wittig‐Reaktion
lösungsmittelfreien
vor,
welches
mühsame
initiale
Ylid‐Bildung
striktem
Luft‐
Feuchtigkeitsausschluss
oft
überflüssig
macht.
Eine
Reihe
Aldehyden
Ketonen
wurde
mit
verschiedenen
Phosphoniumsalzen
mittels
hochenergetischem
Kugelmahlen
umgesetzt,
wobei
Olefine
häufig
nur
zugänglich
waren.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 27, 2023
Abstract
The
call
for
implementing
inhibitory
methods
in
cancer
treatment
has
intensified.
Recently,
deeply
affected
society,
with
Acute
Myeloid
Leukemia
(AML)
being
identified
as
one
of
the
most
formidable
and
lethal
adversaries.
This
research
investigates
intricate
interactions
between
vitamins
A,
B,
C,
D,
E,
K
critical
signaling
pathways,
such
NPM1,
FLT3,
RUNX1,
uncovering
meaningful
associations.
Employing
precision
molecular
docking
Autodock
Vina
1.5.7,
a
thorough
exploration
these
was
carried
out.
analysis
entailed
detailed
examination
hydrophilic
hydrophobic
aspects
using
LigPlot,
complemented
by
additional
insights
visualized
through
PyMol.
considerable
occurrence
observed
interactions,
coupled
noteworthy
binding
energy,
underscores
potential
vitamin-related
derivatives
promising
contenders
treatments.
However,
realization
this
is
contingent
upon
subsequent
investigations,
including
comprehensive
RT-qPCR
studies.
While
study
successfully
significant
dynamics
gene
expression
necessitate
studies
to
attain
holistic
understanding
both
upregulation
downregulation.
In
conclusion,
revelations
from
not
only
set
stage
treatments
AML
strategic
application
vitamin-based
but
also
underscore
transformative
capabilities
derivatives.
future
endeavors,
should
vitamin
reveal
substantial
downregulation,
stand
poised
spearhead
innovative
treatments,
marking
era
targeted
drug
delivery.
