Continuous flow synthesis of the antiviral drug tecovirimat and related sp3-rich scaffolds DOI Creative Commons
Arlene Bonner, Marcus Baumann

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Fast, high-yielding syntheses of a medicinally relevant sp 3 -rich polycyclic scaffold have been developed and its synthetic utility demonstrated in range condensation reactions.

Language: Английский

Regioselective Synthesis of Multisubstituted 2,3-Dihydrooxazoles by 1,3-Dithiane Umpolung DOI
Xiang‐Rong Xu, Ruipeng Li, Zhuzhu Zhang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(32), P. 6825 - 6829

Published: Aug. 7, 2024

Herein, we report a novel strategy for the regioselective synthesis of aromatic and heteroaromatic 2,3-dihydrooxazoles from 2-alkynyl-1,3-dithianes nitrones. This method exploits 1,3-dithiane umpolung, nucleophilic cycloaddition, rearrangement processes to achieve rapid assembly dihydrooxazole molecules. The is extremely mild, achieving complete conversion within one min under air at 25 °C with high efficiency.

Language: Английский

Citations

2
Continuous flow synthesis of the antiviral drug tecovirimat and related sp3-rich scaffolds DOI Creative Commons
Arlene Bonner, Marcus Baumann

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Fast, high-yielding syntheses of a medicinally relevant sp 3 -rich polycyclic scaffold have been developed and its synthetic utility demonstrated in range condensation reactions.

Language: Английский

Citations

0