ACS electrochemistry., Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Language: Английский
Nature Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
6
Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
A scalable electrochemical process to synthesize iminophosphorane ligands is reported. The application of these iminophosphoranes was recently reported in Ni-catalyzed cross-electrophile and C–N cross-couplings. use parallel plate flow reactors enables the synthesis on a multigram scale, with selected examples up 0.6 kg scale. Direct crystallization from end reaction mixture for provides facile isolation processes. This article also details improvements our capabilities across scales, including addressing material compatibility issues, increasing accessible range rates, integration analytical technology tools.
Language: Английский
Citations
2
Published: May 10, 2024
Aminoalcohols are expressed in natural products, blockbuster pharmaceuticals, agrochemicals, and key building blocks for innumerable society-benefitting applications. Historically their synthesis relies on polar-bond retrosynthetic analysis often suffers from extensive protecting/functional group manipulation chemistry that hinders direct access. Here we show how a simple serine-derived chemical cassette can be leveraged series of electrocatalytic transformations to dramatically simplify the way such structures made enantio- chemoselectively modular fashion. This used rapidly create libraries useful radical logic employed applied truncate known structures. methodology large scale as well demonstrated with unique flow reactor setup.
Language: Английский
Citations
4
Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
We report the application of rotating cylinder electrode (RCE) reactors for electrolysis heterogeneous reactions in batch and recirculating flow. A scalable method synthesis an N-cyano iminophosphorane ligand RCE reactor is also reported. In development this process, a graphite felt attached to inner impervious was used as anode, outer stainless steel wall cathode. The reaction first evaluated using small optimize spinning rate, supporting electrolyte, current density. optimal condition then scaled up medium-sized with modifications adapt it flow process. electrosynthesis demonstrated 100 g scale, impact temperature investigated. Finally, operationally simple direct crystallization water antisolvent provided chiral 74% isolated yield on scale from commercially available (S)-BINAP bis(trimethylsilyl)carbodiimide.
Language: Английский
Citations
0
Chemie Ingenieur Technik, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Abstract Organic electrosynthesis is a potential enabler for the energy and resource transition in chemical industry as it offers sustainable alternative to homogeneous or heterogeneous processes producing fine commodity chemicals. It utilizes electricity instead of hazardous reagents and, thus, also allows reducing product's carbon footprint waste production. enables dynamic operation safe due galvanostatic process control. Electro‐organic are not yet widespread. Engineering tools have been tailored electro‐organic processes, more quantitative model‐based insight needed. Extensive adoption requires efforts regarding electrode material performance stability, scalable reactor design, digitization. Addressing these issues interdisciplinary collaboration, particularly between chemists engineers, accelerate implementation with high efficiency economic feasibility.
Language: Английский
Citations
0
Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Chemical process development is a critical component in the for active pharmaceutical ingredients (APIs). With interfaces to drug discovery and API manufacturing, chemical activities must deliver scalable, safe, cost-efficient, sustainable, reliable processes novel as well marketed APIs. Despite its importance industry society, domain of development, together with advances challenges, often not known nonpractitioners. As scientists, we provide scientific perspective on state affairs which believe will be value broader audience, including academic researchers, students, professionals from related fields.
Language: Английский
Citations
0
Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown
Published: March 28, 2025
Language: Английский
Citations
0
Angewandte Chemie, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
Abstract Chemical process development is a critical component in the for active pharmaceutical ingredients (APIs). With interfaces to drug discovery and API manufacturing, chemical activities must deliver scalable, safe, cost‐efficient, sustainable, reliable processes novel as well marketed APIs. Despite its importance industry society, domain of development, together with advances challenges, often not known nonpractitioners. As scientists, we provide scientific perspective on state affairs which believe will be value broader audience, including academic researchers, students, professionals from related fields.
Language: Английский
Citations
0
ACS electrochemistry., Journal Year: 2025, Volume and Issue: unknown
Published: May 15, 2025
Language: Английский
Citations
0