Industry Perspective on the Selection of Regulatory Starting Materials for Synthetic Peptides
Organic Process Research & Development,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 26, 2025
Language: Английский
Chemical Process Development in the Pharmaceutical Industry in Europe—Insights and Perspectives from Industry Scientists
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Chemical
process
development
is
a
critical
component
in
the
for
active
pharmaceutical
ingredients
(APIs).
With
interfaces
to
drug
discovery
and
API
manufacturing,
chemical
activities
must
deliver
scalable,
safe,
cost-efficient,
sustainable,
reliable
processes
novel
as
well
marketed
APIs.
Despite
its
importance
industry
society,
domain
of
development,
together
with
advances
challenges,
often
not
known
nonpractitioners.
As
scientists,
we
provide
scientific
perspective
on
state
affairs
which
believe
will
be
value
broader
audience,
including
academic
researchers,
students,
professionals
from
related
fields.
Language: Английский
Chemical Process Development in the Pharmaceutical Industry in Europe—Insights and Perspectives from Industry Scientists
Angewandte Chemie,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Abstract
Chemical
process
development
is
a
critical
component
in
the
for
active
pharmaceutical
ingredients
(APIs).
With
interfaces
to
drug
discovery
and
API
manufacturing,
chemical
activities
must
deliver
scalable,
safe,
cost‐efficient,
sustainable,
reliable
processes
novel
as
well
marketed
APIs.
Despite
its
importance
industry
society,
domain
of
development,
together
with
advances
challenges,
often
not
known
nonpractitioners.
As
scientists,
we
provide
scientific
perspective
on
state
affairs
which
believe
will
be
value
broader
audience,
including
academic
researchers,
students,
professionals
from
related
fields.
Language: Английский
Recent Advances in the Application of Foodborne Substances in Hyperuricemia
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Hyperuricemia
(HUA)
is
a
purine
metabolism
disorder
characterized
by
the
excessive
production
or
inadequate
excretion
of
uric
acid.
Current
pharmacological
strategies
targeting
acid
reduction
have
potential
adverse
effects.
Following
concept
"homology
medicine
and
food",
food
ingredients
are
increasingly
being
explored
to
prevent
HUA
gout,
with
xanthine
oxidase
(XOD)
emerging
as
crucial
therapeutic
target
in
managing
HUA.
Recent
scientific
investigations
determined
that
acid-lowering
substances
come
from
various
sources,
such
seafood,
dairy
products,
agricultural
products.
These
bioactive
attracted
wide
attention
because
their
effective
antihyperuricemia
XOD
inhibitory
ability.
In
this
study,
pathogenesis,
many
side
effects
drugs,
some
components
drugs
mainly
described,
emphasis
on
source,
composition,
preparation
technology,
mechanism
peptides.
Language: Английский
Three-Step Continuous Flow Synthesis of the Intermediate 4-Fluoro-2-methoxy-5-nitrophenol of Linzagolix
Tengfei Gong,
No information about this author
Fei Ji,
No information about this author
Yang Shi
No information about this author
et al.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 18, 2024
4-Fluoro-2-methoxy-5-nitrophenol
is
a
key
intermediate
of
the
GnRH
receptor
antagonist
Linzagolix.
The
traditional
synthetic
methods
have
several
disadvantages
including
prolonged
reaction
time
and
safety
issues.
Herein,
we
describe
three-step
continuous
flow
synthesis
4-fluoro-2-methoxy-5-nitrophenol
via
esterification,
nitration,
hydrolysis.
total
residence
was
234
s,
yield
85.6%,
which
substantially
reduced
considerably
improved
process
as
well
yield.
Language: Английский