Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part I: Synthesis of the Pyridazinyl Imidazolidinone Intermediate Enabled by Biocatalysis and CSTR Technologies DOI
Qiang Yang, Yu Lu, Thomas J. Beauchamp

et al.

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Development of a Scalable Process for an IL-17A Inhibitor LY3509754. Part II: Synthesis of the α-Bromoketone Intermediate Leveraging Concomitant Decarboxylation Following Enzymatic Ester Hydrolysis DOI
Qiang Yang, Yu Lu, Thomas J. Beauchamp

et al.

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

2
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control DOI
Qiang Yang,

Ryan J. Linder,

Yu Lu

et al.

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Language: Английский

Citations

1
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part I: Synthesis of the Pyridazinyl Imidazolidinone Intermediate Enabled by Biocatalysis and CSTR Technologies DOI
Qiang Yang, Yu Lu, Thomas J. Beauchamp

et al.

Organic Process Research & Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0