Methanol-Mediated Formation of an Iridium(III) NHC/Azolato Chelate Complex: An Experimental and Theoretical Study DOI

Patrick D. Dutschke,

Brian T. H. Tsui, Maximilian von Bremen-Kühne

et al.

Organometallics, Journal Year: 2022, Volume and Issue: 41(23), P. 3732 - 3740

Published: Nov. 29, 2022

One equivalent of methanol-d4 reacts with the iridium(III)-carbonato-NHC complex [Ir(Cp*)(NHC-theo)(O2CO)] [1] containing an N-heterocyclic carbene ligand N-tethered C8-iodotheophylline group (NHC-theo) to form iridium(III) chelate [Ir(Cp*)(theophyllinato^NHC)I] [2] that bears a theophyllinato^NHC ligand, iodo and pentamethylcyclopentadienyl (Cp*). The solvent is oxidized formaldehyde-d2 was identified by detailed LC–MS study using 2,4-dinitrophenylhydrazine (DNPH) method. A plausible rearrangement involving unusual oxidative addition C8–I bond theophylline center give seven-coordinate iridium(V) intermediate supported density functional theory calculations.

Language: Английский

Advances in the Synthesis and Applications of N-Heterocyclic Carbene Metal Complexes with a Focus on the Weak Base Route DOI
Thomas Scattolin, Aleksei A. Logvinov, Nikolaos V. Tzouras

et al.

Organometallics, Journal Year: 2023, Volume and Issue: 42(19), P. 2692 - 2730

Published: Sept. 21, 2023

N-heterocyclic carbene (NHC) ligands have evolved from being simple lab curiosities to tertiary phosphine mimics finally take center stage as unique supporting in organometallic chemistry, homogeneous catalysis, and more recently medicinal chemistry materials science applications. Some of these aspects are presented here a perspective researchers that been fascinated by the area for quite some time.

Language: Английский

Citations

24
Greening up organic reactions with caffeine: applications, recent developments, and future directions DOI Creative Commons
Ankita Chaudhary, Divya Mathur,

Ritu Gaba

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(13), P. 8932 - 8962

Published: Jan. 1, 2024

Among the diverse natural catalysts, caffeine has emerged as a green, expedient, non-toxic, and biodegradable catalyst. The main objective of this review is to present existing knowledge pertaining exploitation in various organic transformations.

Language: Английский

Citations

8
Biological impact of Pd(II) complexes: Synthesis, crystal structure, Hirshfeld surface analysis, NCI-RDG, molecular docking, molecular dynamic simulations DOI

Guerfi Samiaa,

Donia Bensalah,

Berredjem Yamina

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122691 - 122691

Published: April 1, 2025

Language: Английский

Citations

0
Silver(I) complexes containing N-heterocyclic carbene azole drugs: Synthesis, characterization, cytotoxic activity, and their BSA interactions DOI

Camila Aparecida da Silva dos Reis Condé,

Ana Luiza de Andrade Querino, Heveline Silva

et al.

Journal of Inorganic Biochemistry, Journal Year: 2023, Volume and Issue: 246, P. 112303 - 112303

Published: June 23, 2023

Language: Английский

Citations

6
Catalysis of a Bis-Caffeine Palladium(II) NHC-Pincer Complex DOI Creative Commons
Oliver Bysewski, Andreas Winter, Ulrich S. Schubert

et al.

Inorganics, Journal Year: 2023, Volume and Issue: 11(4), P. 164 - 164

Published: April 13, 2023

A tridentate bis-NHC Pd complex, based on caffeine, was studied for its catalytic activity. This complex displayed a high activity in the Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions of aryl halides. The Sonogashira also investigated but reveals fast plateauing reaction. Aryl iodides as well bromides react when equipped with either electron-donating or electron-withdrawing substituents. chlorides, which contained groups, were reactive under applied conditions.

Language: Английский

Citations

4
Synthesis, Characterization, and Catalytic Evaluation of Ruthenium Complexes Bearing Xanthinium-8-dithiocarboxylate Ligands Derived from Caffeine and Theophylline DOI

François Mazars,

Guillermo Zaragoza, Lionel Delaude

et al.

Organometallics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский

Citations

1
Noble Metal Complexes of a Bis-Caffeine Containing NHC Ligand DOI Creative Commons
Oliver Bysewski, Andreas Winter, Phil Liebing

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(13), P. 4316 - 4316

Published: July 5, 2022

N-Heterocyclic carbenes (NHCs) have seen more and use over the years. The go-to systems that are usually considered derivatives of benzimidazole or imidazole. Caffeine possesses an imidazole unit was already utilized as a carbene-type ligand; however, its within tridentate bis-NHC system has-to best our knowledge-not been reported so far. synthesis ligand is straightforward metal complexes readily available via silver-salt metathesis. A platinum(II) palladium(II) complex were isolated crystal structure former examined. For Pt(II) complex, luminescence observed in solid state well solution.

Language: Английский

Citations

4
Nitrosamine Impurities in Herbal Formulations: A Review of Risks and Mitigation Strategies DOI
Raja Shekhar Nunavath, Krishnaveni Nagappan,

Madhu Tanya Singh

et al.

Drug Research, Journal Year: 2023, Volume and Issue: 73(08), P. 431 - 440

Published: July 24, 2023

Abstract Nitrosamines are a class of chemical compounds that have been found to be impurities in variety pharmaceutical products. These raised concerns due their potential carcinogenic effects. Recent studies identified nitrosamines as number products including angiotensin II receptor blockers (ARBs) and proton pump inhibitors (PPIs). The presence these has led recalls market withdrawals. In addition pharmaceuticals, also some herbal medicines particularly those containing traditional Chinese medicinal ingredients. formulations poses significant risk public health highlights the need for quality control regulations drug industry. present review article aims discuss nitrosamine (NMI) prominent causes, risks scientific strategies preventing NMI formulations. primary objective this study is examine origins contamination formulations, associated with contaminants, methods reducing them. significance thorough testing examination before releasing emphasized. conclusion, not limited threat safety drugs well. Adequate extensive research crucial producing distributing general population.

Language: Английский

Citations

2
Palladium‐N‐heterocyclic Carbene Complexes: Synthesis, Characterization and Catalytic Application of C−H Activation for Carboxaldehyde Derivatives DOI
Neslihan Şahin

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Oct. 1, 2024

Abstract A series of palladium‐ N ‐heterocyclic carbene complexes ( 2 a‐e ) were synthesized from corresponding precursors 1 in good yields. The structural analysis all novel compounds was done by spectroscopic methods and elemental also performed to evaluate the purity complexes. Further confirmations a‐d provided X‐ray crystallography technique. Under optimized reaction conditions, catalytic activity reviewed direct arylation furan‐2‐carboxaldehyde 1‐methylpyrrole‐2‐carboxaldehyde with varied aryl halides. This showed productive selective at C5‐position heteroaryl derivatives.

Language: Английский

Citations

0
Coordination Chemistry of Ir with Chelating Ligands Containing a Xanthine‐Derived, Protic N‐Heterocyclic Carbene (NHC) Moiety DOI Creative Commons
Matteo Bevilacqua, Valerio Giuso, Marzio Rancan

et al.

European Journal of Inorganic Chemistry, Journal Year: 2022, Volume and Issue: 2022(34)

Published: Oct. 7, 2022

Abstract A series of protic N‐heterocyclic carbene ligand precursors based on theophylline or adenine has been prepared, and the reactivity coordination chemistry these proligands towards iridium(III) centers investigated. Complex formation appears to be highly dependent proligand structure. In one case, a particularly stable complex is formed that enables fully reversible protonation/deprotonation coordinated NHC moiety. The acidity constant protonated was consequently determined.

Language: Английский

Citations

1