Topics in organometallic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 141 - 223
Published: Jan. 1, 2023
Language: Английский
RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 15(10), P. 3286 - 3344
Published: Jan. 1, 2024
This review aims to highlight the role of silicon in drug discovery.
Language: Английский
Citations
10
ChemCatChem, Journal Year: 2024, Volume and Issue: 16(15)
Published: Feb. 5, 2024
Abstract The selective conversion of unsaturated compounds has emerged as a crucial method in chemical synthesis, enabling the synthesis functional organic molecules. In recent decades, transition metal‐catalyzed hydrosilylation highly successful exemplar industrialization within realm chemistry for production organosilanes, which have pivotal role and materials science. Precious metal complexes are typically employed catalysts most industrial processes. exploration Earth‐abundant alternatives focal point considerable research attention due to high cost, poor selectivity, many side reactions reported precious catalysts. Ligand skeleton construction, mechanism areas where cobalt more potential than iron nickel. This review discusses advances cobalt‐catalyzed across carbon‐carbon, carbon‐oxygen, carbon‐nitrogen multiple bonds from 2019 2023.
Language: Английский
Citations
7
Catalysts, Journal Year: 2023, Volume and Issue: 13(3), P. 510 - 510
Published: March 2, 2023
The hydrosilylation of alkynes is one the most attractive and, at same time, challenging catalytic transformations, usually demanding use noble transition metals. We describe a system, based on cobalt(0) complex and bulky N-heterocyclic carbene (NHC) ligands, permitting highly effective broad scope silanes. application NHC ligands allowed decrease in amount cobalt necessary for an reaction run to 2.5 mol% provided excellent selectivity towards α-vinylsilanes. developed method tolerates number substituted aryl, alkyl, silyl acetylenes. Moreover, it suitable both tertiary secondary Our findings confirm that steric hindrance around metal center can effectively increase activity catalyst ensure better than those analogous complexes bearing smaller ligands.
Language: Английский
Citations
12
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: May 14, 2025
Language: Английский
Citations
0
ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(6), P. 4001 - 4007
Published: Feb. 28, 2024
Transition-metal-catalyzed cyclization/hydrosilylation of 1,6-diynes is a useful method for the preparation five-membered ring-fused silyl dienes that are reagents in organic synthesis. Only handful noble metal catalysts facilitating this transformation known, and nonprecious effecting reaction have remained elusive. Herein, we report low-coordinate Co(0)-N-heterocyclic carbene complexes can catalyze with tertiary secondary hydrosilanes, furnishing (Z)-1-silyldienes good yields excellent stereoselectivity. Mechanistic study disclosed catalytic cycle likely has oxidative cyclization Co(0) species as key step. This mechanism accounts high stereoselectivity absence uncyclized hydrosilylation byproducts cobalt-catalyzed reaction, which different from hydrosilylation-cyclization metal-catalyzed reactions.
Language: Английский
Citations
3
Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(16), P. 1860 - 1866
Published: April 18, 2024
Comprehensive Summary By rational modification of electronic and steric properties pincer ligands, a Co/Fe dual catalyst system is developed for one‐pot sequential Markovnikov alkyne hydrosilylation stereoselective alkene isomerization. The protocol provides an atom‐economical efficient approach to trisubstituted ( E )‐alkenyl silanes from widely accessible terminal alkynes with high regio‐ stereoselectivities under mild conditions. utility this reaction was demonstrated by gram‐scale synthesis derivatization bioactive molecules. radical clock trapping experiments indicated that pathway might be operative in the isomerization step.
Language: Английский
Citations
1
Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(9), P. 3524 - 3544
Published: Aug. 9, 2024
Developing catalytic reactions using nonprecious-metal to achieve various synthetic transformations remains a valuable pursuit the scientific community. As part of continuing review series that is published within precompetitive chemistry alliance between AbbVie, Boehringer Ingelheim and Pfizer, this article underscores wide-ranging uses Cu-, Co-, Fe-, Ni-catalysis. The significant uptick in NPMC-related publications signifies escalating curiosity among researchers investigate advance capabilities these metals.
Language: Английский
Citations
1
The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(24), P. 16997 - 17009
Published: Nov. 30, 2023
Here, commercially available Co2(CO)8 was utilized as an efficient catalyst for chemodivergent synthesis of pyrrolidines and pyrrolidones from levulinic acid aromatic amines under slightly different hydrosilylation conditions. 1.5 3 equiv phenylsilane selectively yielded pyrrolidone pyrrolidine, respectively. Various ketoacids were successfully tested. Plausible mechanism involves the condensation amine to form imine, which cyclizes 3-pyrrolidin-2-one followed by reduction pyrrolidone. The final gave pyrrolidine.
Language: Английский
Citations
3
Topics in organometallic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 141 - 223
Published: Jan. 1, 2023
Language: Английский
Citations
2