The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Herein,
we
describe
a
Zn-catalyzed
atom-economical,
inexpensive,
and
sustainable
method
for
preparing
broad
spectrum
of
substituted
olefins
utilizing
alcohols
as
the
main
precursor.
Using
Zn(II)
complex
[ZnLCl2]
(1)
redox-noninnocent
ligand
2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline
(L),
various
(E)-olefins
were
prepared
in
good
yields
by
coupling
with
sulfones
aryl
cyanides
under
an
inert
atmosphere.
Under
aerial
atmosphere,
vinyl
nitriles
isolated
up
to
82%
yield
reacting
benzyl
presence
1.
Control
experiments
mechanistic
investigation
indicate
active
involvement
aryl-azo
electron
hydrogen
reservoir,
permitting
1
perform
promising
catalyst.
Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
63(25), P. 11821 - 11831
Published: June 7, 2024
A
series
of
ruthenium
complexes
(Ru1–Ru4)
bearing
new
NNN-pincer
ligands
were
synthesized
in
58–78%
yields.
All
the
are
air
and
moisture
stable
characterized
by
IR,
NMR,
high-resolution
mass
spectra
(HRMS).
In
addition,
structures
Ru1–Ru3
confirmed
X-ray
crystallographic
analysis.
These
Ru(II)
exhibited
high
catalytic
efficiency
broad
functional
group
tolerance
N-methylation
reaction
amines
using
CH3OH
as
both
C1
source
solvent.
Experimental
results
indicated
that
electronic
effect
substituents
on
considerably
affects
reactivity
which
Ru3
an
electron-donating
OMe
showed
highest
activity.
Deuterium
labeling
control
experiments
suggested
dehydrogenation
methanol
to
generate
hydride
species
was
rate-determining
step
reaction.
Furthermore,
this
protocol
also
provided
a
ready
approach
versatile
trideuterated
N-methylamines
under
mild
conditions
CD3OD
deuterated
methylating
agent.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(10)
Published: March 1, 2025
Abstract
Recently,
quinoline
has
emerged
as
a
critical
heterocyclic
structure,
attracting
attention
for
its
diverse
industrial
and
synthetic
organic
chemistry
applications.
This
compound
is
essential
developing
novel
lead
compounds
in
drug
discovery
extensively
studied
therapeutic
derivatives
medicinal
chemistry.
An
extensive
body
of
literature
details
the
methodologies
synthesizing
this
key
scaffold
functionalization
to
enhance
biological
efficacy.
Numerous
synthesis
protocols
have
been
documented,
highlighting
significance
ongoing
chemical
research.
These
include
various
strategies,
such
transition
metal‐catalyzed
reactions
environmentally
sustainable
processes,
which
are
crucial
constructing
functionalizing
derivatives.
review
aims
systematically
examine
procedures
findings,
addressing
limitations
these
pathways
their
environmental
impacts.
Additionally,
curated
selection
quinolines
will
be
presented.
Catalysis Science & Technology,
Journal Year:
2023,
Volume and Issue:
14(1), P. 26 - 42
Published: Nov. 15, 2023
Among
the
vast
family
of
aminoalcohol
ligands,
2-pyridonates
take
a
special
position.
This
review
illustrates
intriguing
properties
pyridonate
ligands
and
their
key
roles
in
3d
transition
metal
catalysts
from
natural
role
model
[Fe]-hydrogenase
to
modern
applications.
Catalysis Science & Technology,
Journal Year:
2024,
Volume and Issue:
14(20), P. 5959 - 5969
Published: Jan. 1, 2024
This
manuscript
describes
the
synthesis
of
triazolyl-pyridine-based
pincer
cationic
and
neutral
nickel
complexes
their
application
in
microwave-assisted
quinolines.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
In
this
report,
a
new
imidazole-
and
amide-functionalized
pincer-like
Cu(II)
complex
(1)
was
synthesized
characterized.
By
employing
1
9-azabicyclo[3.3.1]nonane
NH-Oxyl
(ABNOH),
catalytic
protocol
for
alcohol
oxidation
the
subsequent
oxidation-triggered
synthesis
of
quinolines
pyrazines
were
explored.
Alcohols
such
as
2-aminoaryl
alcohols
also
oxidized
efficiently.
As
carbonyls
from
2-arylaminobenzyl
secondary
are
synthons
quinolines,
we
explored
their
directly
alcohols.
The
quite
efficient
completed
reaction
in
only
∼5–10
h.
Combinations
(a)
primary
with
or
ketones
(b)
found
to
be
very
effective
quinolines.
successful
various
1,2-diols
1,2-diaminobenzenes
10
Mechanistic
investigations
showed
that
generated
acted
an
active
catalyst:
it
activated
O2
subsequently
cooperation
N-Oxyl
(ABNO•)
α-CH
hydrogen
coordinated
alkoxide.
Then,
Cu(II)/Cu(I)
reduction
led
formation
carbonyl
compounds,
which
via
successive
C–C/C–N
coupling
reactions
resulted
heterocycles
presence
KOtBu
1.
Dalton Transactions,
Journal Year:
2024,
Volume and Issue:
53(12), P. 5580 - 5591
Published: Jan. 1, 2024
This
manuscript
describes
the
synthesis
and
Mn
I
complexes
of
triazolyl-pyridine-based
phosphine
ligand
their
catalytic
utility
in
quinoline
derivatives
transfer
hydrogenation
aldehydes
ketones.
ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(45)
Published: Dec. 1, 2023
Abstract
Catalytic
hydrogenation/dehydrogenation
reactions
are
one
of
the
most
active
areas
research
for
synthesis
pharmaceuticals
and
fine
chemicals.
Despite
several
efficient
homogeneous
catalysts
that
have
already
been
identified,
highly
heterogeneous
remain
elusive.
Herein,
we
report
an
easy
convenient
wet
impregnation
method
Pd‐nanoclusters
supported
on
ZnO
nanoparticles.
The
catalyst
displays
a
multifunctional
role
in
2‐aryl
quinolines
using
alcohol
2‐nitrobenzyl
as
reactants
via
dehydrogenation/hydrogenation
pathway
under
neat
base‐free
reaction
conditions.
exhibits
excellent
selectivity
can
be
recycled
five
times
without
appreciable
loss
its
activity.
