The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(9), P. 6120 - 6125
Published: April 5, 2023
Simple,
versatile,
and
catalyst-free
synthetic
methods
for
β-keto
dithiocarbamates,
thiazolidine-2-thiones,
thiazole-2-thiones
via
the
multicomponent
reaction
of
CS2,
amines,
sulfoxonium
ylides
have
been
described.
The
furnished
dithiocarbamates
in
presence
CS2
secondary
whereas
primary
amines
afforded
thiazolidine-2-thiones
or
after
dehydration
an
acidic
environment.
With
simple
procedures,
has
a
wide
substrate
scope
excellent
functional
group
tolerance.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(28), P. 5329 - 5332
Published: July 7, 2023
A
novel
straightforward
and
catalyst-free
approach
for
synthesizing
quinoxaline
derivatives
from
sulfoxonium
ylides
o-phenylenediamines
mediated
by
elemental
sulfur
has
been
described.
Due
to
the
simple
mild
reaction
conditions,
decorated
with
different
functional
groups
furnished
moderate
high
yields
of
were
well
tolerated.
Finally,
large-scale
reactions,
synthesis
pyrazines,
some
bioactive
compounds
are
used
illustrate
potential
utility
developed
approach.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(32)
Published: April 3, 2024
Abstract
This
paper
presents
a
green
and
efficient
aqueous‐phase
method
for
the
synthesis
of
thiosulfonates,
which
has
benefits
no
need
catalysts
or
redox
reagents
short
reaction
time,
providing
with
great
economic
value
synthesizing
thiosulfonates.
Furthermore,
3‐Sulfenylindoles
can
be
easily
synthesized
using
this
method,
expands
potential
applications
reaction.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(18), P. 13601 - 13607
Published: Sept. 4, 2024
A
zinc-mediated
cross-electrophile
coupling
of
benzyl
sulfonium
salts
with
thiosulfonates
via
C-S
bond
cleavage
was
achieved.
The
reductive
thiolation
proceeded
well
under
transition
metal-free
conditions
to
afford
the
desired
sulfides
in
good
yields,
exhibiting
both
broad
substrate
scope
and
functionality
tolerance.
In
addition,
reaction
could
be
applied
use
selenosulfonate
as
an
effective
selenylation
agent
subjected
scale-up
synthesis.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(89), P. 12443 - 12446
Published: Jan. 1, 2022
Herein,
a
method
to
access
3-trifluoromethyl-1,4-benzoxazines
from
CF3-imidoyl
sulfoxonium
ylides
and
2-bromophenols
has
been
demonstrated.
This
synthetic
protocol
proceeds
via
one-pot
two-step
sequence
that
includes
the
lithium-bromide-promoted
O-H
insertion
of
annulation,
merits
broad
substrate
scope,
excellent
functional
tolerance
operational
simplicity,
which
provides
an
alternative
means
obtaining
CF3-substituted
heterocycles.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
14(3), P. 604 - 612
Published: Dec. 3, 2022
Visible-light-mediated
methods
were
heavily
studied
as
a
useful
tool
for
cysteine-selective
bio-conjugation;
however,
many
current
suffer
from
bio-incompatible
reaction
conditions
and
slow
kinetics.
To
address
these
challenges,
herein,
we
report
transition
metal-free
thiol-sulfoxonium
ylide
photo-click
that
enables
bioconjugation
under
bio-compatible
conditions.
The
is
highly
generally
finished
within
minutes
with
naturally
occurring
riboflavin
derivatives
organic
photocatalysts.
catalysts
substrates
are
readily
accessible
bench
stable
have
satisfactory
water
solubility.
As
proof-of-concept
study,
the
was
smoothly
applied
in
chemo-proteomic
analysis,
which
provides
efficient
tools
to
explore
druggable
content
of
human
proteome.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(2), P. 787 - 787
Published: Jan. 12, 2023
In
recent
years,
the
importance
of
“environmentally
friendly
manufacturing”
has
been
increasing
toward
establishment
a
resource-recycling
society.
organic
synthesis,
as
well,
it
is
becoming
increasingly
important
to
develop
new
synthetic
strategies
with
resource
conservation
and
recycling
elemental
resources
in
mind,
rather
than
just
only
synthesis.
Many
studies
on
construction
frameworks
functional
molecules
using
ionic
reactions
transition-metal-catalyzed
have
reported,
but
most
them
focused
formation
carbon–carbon
bonds.
However,
essential
introduce
appropriate
groups
at
positions
order
for
express
their
functions,
furthermore,
highly
selective
preparation
multiple
considered
creation
molecules.
this
review,
we
focus
radical
high
group
selectivity
overview
progress
practical
methods
simultaneous
introduction
propose
future
that
emphasize
environmental
friendliness.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(68), P. 10247 - 10250
Published: Jan. 1, 2023
Efficient,
versatile,
and
metal-free
strategies
for
synthesizing
α-thiocyanoketones
thiazoles
from
β-ketosulfoxonium
ylides
ammonium
thiocyanate
have
been
described.
Due
to
its
simplicity,
benign
reaction
conditions,
excellent
chemoselectivity,
high
yield,
this
method
represents
a
unique
approach
divergent
synthesis.
Finally,
the
potential
value
of
developed
methods
is
demonstrated
via
large-scale
reactions
synthesis
Fanetizole,
an
anti-inflammatory
drug.
Journal of Heterocyclic Chemistry,
Journal Year:
2023,
Volume and Issue:
61(1), P. 29 - 70
Published: Oct. 26, 2023
Abstract
Sulfur
ylides
are
versatile
structures
that
display
various
characteristics
and
participate
in
a
myriad
of
reactions
to
produce
simple,
effective,
sometimes
stereoselective
toward
synthesizing
sulfur‐containing
compounds.
Nonetheless,
their
fulfillment
tremendous
developments
have
been
made
this
field
the
past
few
decades.
In
comprehensive
review,
luminosity
is
illuminated
on
application
sulfur
involved
domino,
cascade
annulation
reactions,
carbene
trapping
reagents
with
chameleonic
reactivity.
numerous
decennary,
chemists
used
solvent‐dependent,
rhodium
catalyzed,
dealkylative
intercepted,
photochemical
reaction,
halotrifluoromethylation,
benzannulation,
amidation
name
such
as
Mizoroki–Heck,
Suzuki–Miyaura,
Sommelet–Hauser
rearrangements.
Moreover,
other
prime
applications
include
metal
catalysis,
epoxidation
carbonyl
compounds,
acylmethylation,
cyclomerization,
oxidation,
insertion
reactions.
Additionally,
some
extremely
useful
play
major
role
synthesis
medicinally
active
heterocycles
structural
motifs.
This
review
article
discusses
all
these
proposed
mechanisms,
current
scenario,
at
length.
tutorial
concludes
by
providing
future
outlook
investigation
into
compounds
synthesized
using
it
great
potential
be
industries,
laboratories,
pharmaceutical
companies,
drug
production,
clinical
use,
medicinal
chemistry,
agrochemical
purposes.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(12), P. 1367 - 1372
Published: Feb. 23, 2024
Comprehensive
Summary
The
selective
oxidative
sulfonylation
of
alkenes
with
selenium
sulfonate
depended
on
the
reaction
conditions.
electrochemical
C—H
proceeded
smoothly
to
afford
(
E
)‐vinyl
sulfones
good
selectivity
in
an
undivided
cell
without
external
oxidant.
While
aerobic
trifunctionalization
occurred
presence
KI
air,
which
provides
β
‐keto
selenosulfones
via
formation
C—O,
C—S,
and
C—Se
bonds
one‐pot.
Following
control
experiments,
a
plausible
mechanism
is
proposed
rationalize
experimental
results.
