The Royal Society of Chemistry eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 147 - 167
Published: Feb. 15, 2023
Heterocycles containing chalcogens as heteroatoms or embedded in several different functional groups founded interesting applications medicinal chemistry, coordination and materials. Recent development on their preparation is reported here.
Language: Английский
Chemical Communications, Journal Year: 2023, Volume and Issue: 59(36), P. 5343 - 5364
Published: Jan. 1, 2023
The activation and transformation of organic chemical bonds is a fundamental scientific problem. In the past several decades, C-S bond cleavage for construction C-C C-heteroatom has received tremendous attention in chemistry. Although significant progress been made field transition metal strategies, variety novel transition-metal-free strategies have also developed using halogenated reagents, oxidants, acids, bases. Moreover, photochemical electrochemical methods to achieve organosulfur compounds. To date, however, no comprehensive review reported. Therefore, we herein provide major advances compounds, including thioethers, sulfoxides, sulfones, thioacetals, sulfonium salts, sulfur ylides.
Language: Английский
Citations
42
Chemical Communications, Journal Year: 2021, Volume and Issue: 57(86), P. 11285 - 11300
Published: Jan. 1, 2021
Visible light mediated functionalizations have significantly expanded the scope of alkynes by unraveling new mechanistic pathways and enabling their transformation to diverse structural entities. The photoredox reactions on rely innate capability generate myriad carbon-centred radicals via single electron transfer (SET), thereby, allowing introduction radical precursors. Moreover, an array methods been developed facilitating transformations such as vicinal or gem-difunctionalization, annulation, cycloaddition oxidative construct numerous key building blocks natural pharmaceutically important molecules. In addition, chemistry has successfully used deal with challenges associated alkyne functionalization stereoselective regioselective control. This article accounts for several visible alkynes, wherein they transformed into α-oxo compounds, β-keto sulfoxides, substituted olefins, N-heterocycles, internal sulfur containing compounds. primarily categorized various sections based reaction type particular attention being paid details, advancement future applications.
Language: Английский
Citations
51
Organic Letters, Journal Year: 2023, Volume and Issue: 25(13), P. 2372 - 2376
Published: March 27, 2023
A novel trifluoromethylation of (hetero)arenes and polarized alkenes using simple trifluoroacetic anhydride (TFAA) as the low price CF3 source under photoredox catalysis was developed without additives such bases, hyperstoichiometric oxidant, or auxiliaries. The reaction showed excellent tolerance, including to some important natural products prodrugs, even on gram scale extended ketones. This protocol provides a practical utilization TFAA. Several perfluoroalkylations trifluoromethylation/cyclizations were successfully achieved identical conditions.
Language: Английский
Citations
22
Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 364(13), P. 2163 - 2168
Published: June 3, 2022
Abstract A visible‐light‐induced regioselective tandem enamido β‐C( sp 2 )−H alkylation/acrylamido alkylation/cyclizative alkenylation sequence of 3‐aza‐1,5‐dienes is presented. This protocol regiospecific, features a broad substrate scope, and provides direct access to 3,4‐dialkylated 4‐pyrrolin‐2‐ones from readily available N ‐alkenylacrylamides. It scalable gram scale, could be induced by natural sunlight. magnified image
Language: Английский
Citations
23
Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(17), P. 4575 - 4582
Published: Jan. 1, 2022
Regioselective cyanoalkylalkenylation of 3-aza-1,5-dienes with oxime esters induced by visible light.
Language: Английский
Citations
21
RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 31, 2024
Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes.
Language: Английский
Citations
4
Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Allyl thioesters, thiocarbonates, thiocarbamates, and thiocyanates are shown to undergo rhodium-catalyzed addition of carbene groups, generated from diazo compounds, afford S-acyl sulfonium ylides that [2,3] sigmatropic rearrangement. Competing side reactions such as cyclopropanation [1,2] acyl shifts not observed. The reaction works with a variety sulfur functional including thiocyanates, affording densely functionalized products. well trimethylsilyldiazomethane (TMSD) α-aryl diazoesters.
Language: Английский
Citations
0
Topics in heterocyclic chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Organic & Biomolecular Chemistry, Journal Year: 2022, Volume and Issue: 20(5), P. 1013 - 1018
Published: Jan. 1, 2022
A reductant-free electroreductive synthesis of polyfunctionalized pyridin-2-ones under the combined action electro/copper/base with O 2 evolution.
Language: Английский
Citations
12
European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(6)
Published: Jan. 5, 2024
Abstract Herein, we disclose a visible‐light‐induced rhodium‐catalyzed oxidative C−H/N−H bond activation of sulfonimidamides (SIAs) and subsequent [4+2] annulation with an alkyne in water to yield SIA‐based 1,2‐benzothiazines good high yields short reaction times. Further, the C=C benzothiazine can be cleaved under environmentally friendly conditions (oxygen atmosphere blue LEDs) deliver o ‐acyl‐ N ‐acyl SIAs. Interestingly, SIAs also synthesized directly from very without isolating benzothiazine. The selective efficient reduction presence InCl 3 /R SiH led formation hitherto unknown dihydro‐1,2‐benzothiazine quantitative yield.
Language: Английский
Citations
2