European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(43)
Published: Oct. 21, 2022
Abstract
The
hydroxyl‐directed
iridium‐catalyzed
peri
‐selective
C−H
bond
activation
to
synthesize
substituted
pyrano[2,3,4‐
de
]chromen‐2‐ones
and
further
chalcogenylation
under
blue
light
irradiation
has
been
realized
efficiently.
Most
products
of
polycyclic
pyrans
corresponding
chalcogenated
derivatives
with
various
substituents
were
achieved
in
good
excellent
yields.
Preliminary
mechanistic
studies
suggest
that
this
transformation
may
pass
through
a
five‐membered
iridacycle
intermediate
containing
an
O−Ir
σ‐bond
photocatalytic
free
radical
process.
An
efficient
synthesis
of
indazole
fused
phenanthridinones
via
Rh(III)-catalyzed
inert
C(sp2)-H
activation/
[4+2]
annulation
3-aryl-1H-indazoles
with
iodonium
ylides
has
been
developed,
providing
a
strategy
to
access
multi-conjugated
π-system
tetracyclic
and
pentacyclic
aza-heterocyclics.
This
“one-pot”
reaction
features
high
efficiency,
excellent
regioselectivity,
broad
substrate
compatibility
could
be
easily
scaled
up.
Notably,
the
photoluminescent
properties
desired
products
appear
charming
valuable.
The
obtained
exhibits
low
toxicity
in
MDCK
cells
as
well
selectively
label
zebrafish
larvae,
which
indicated
that
titled
potentially
utilized
biofluorescent
probes
or
fluorescent
dyes.
Synlett,
Journal Year:
2023,
Volume and Issue:
35(07), P. 811 - 815
Published: Sept. 21, 2023
Abstract
A
ruthenium-catalyzed
selective
C–H
functionalization/annulation
cascade
reaction
of
biindoles
and
sulfoxonium
ylides
has
been
developed.
The
selectively
provides
pyrido[1,2-a:4,3-b′]diindole
(5H-benzo[2,3]indolizino[7,8-b]indole)
derivatives
in
good
yields.
possible
mechanism
for
the
pathway
is
proposed.
More
importantly,
present
study
a
useful
method
construction
frameworks.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
366(3), P. 518 - 525
Published: Dec. 29, 2023
Abstract
A
ruthenium‐catalyzed
C(
sp
2
)−H
acyloxylation
of
2‐aroyl
pyridine
derivatives
with
simple
sodium
carboxylate
utilizing
transformable
directing
groups
is
described.
This
protocol
features
broad
functional
group
tolerance
and
chemo‐
regio‐selectivity,
providing
the
products
in
45%‐84%yield.
Furthermore,
synthetic
utility
this
was
demonstrated
by
late‐stage
functionalization
pharmaceutical
compounds.
Notably,
could
be
further
transformed
into
a
variety
useful
heterocycles
under
mild
conditions.
European Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
2022(43)
Published: Oct. 21, 2022
Abstract
The
hydroxyl‐directed
iridium‐catalyzed
peri
‐selective
C−H
bond
activation
to
synthesize
substituted
pyrano[2,3,4‐
de
]chromen‐2‐ones
and
further
chalcogenylation
under
blue
light
irradiation
has
been
realized
efficiently.
Most
products
of
polycyclic
pyrans
corresponding
chalcogenated
derivatives
with
various
substituents
were
achieved
in
good
excellent
yields.
Preliminary
mechanistic
studies
suggest
that
this
transformation
may
pass
through
a
five‐membered
iridacycle
intermediate
containing
an
O−Ir
σ‐bond
photocatalytic
free
radical
process.
