Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(4), P. 2433 - 2442
Published: Feb. 8, 2023
A
simple
and
concise
method
for
the
synthesis
of
cinnolines
has
been
developed
by
reactions
readily
available
enaminones
aryl
diazonium
tetrafluoroboronates.
The
run
efficiently
to
provide
with
broad
diversity
in
substructure
heating
dimethyl
sulfoxide
without
using
any
catalyst
or
additive.
In
addition,
primary
investigation
anti-inflammatory
activity
these
products
leads
observation
p-chlorobenzoyl
(3f)
p-nitrobenzoyl
(3j)
as
attractive
compounds
vitro.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(1), P. 216 - 223
Published: Dec. 18, 2023
The
C–N
bond
transamidation
of
primary
amides
with
N,N-dimethyl
enaminones
has
been
efficiently
realized
by
heating
in
the
presence
trifluoromethanesulfonic
acid
(TfOH).
method
enables
practical
synthesis
valuable
enamides
without
use
any
metal
reagent.
In
addition,
this
protocol
can
also
be
expanded
to
reactions
sulfonamides,
and
late-stage
functionalization
on
sulfonamide
drugs
such
as
Celecoxib
Valdecoxib
verified.
Moreover,
participation
water
assisting
process
identified
isotope
labeling
experiments
using
D2O,
disclosing
a
new
possibility
designing
catalytic
tactic
other
reactions.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(16), P. 2565 - 2571
Published: April 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(15), P. 10044 - 10053
Published: July 20, 2022
This
study
reports
a
mild
and
efficient
synthetic
protocol
for
the
synthesis
of
symmetrical
unsymmetrical
diarylmethanes
(DAMs).
Using
DMSO
as
C1
source
TMSOTf
Lewis
acid
promoter,
series
functionalized
DAMs
were
synthesized
in
high
yields.
Gratifyingly,
plays
dual
role
solvent
can
also
be
replaced
with
its
deuterated
counterpart,
DMSO-d6,
enabling
incorporation
-CD2
moiety
into
diarylmethane
skeleton.
The
developed
approach
has
been
applied
to
wide
range
substrates
having
various
functional
groups,
this
extended
an
anti-breast
cancer
agent
anticoagulant
using
common
feedstock
compounds.
In
addition,
postulated
mechanism
explicitly
demonstrated
via
control
experiments.
Asian Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
12(1)
Published: Nov. 26, 2022
Abstract
In
multicomponent
reactions,
three
or
more
reactants
combine
in
one
pot
to
form
a
product
without
the
isolation
of
intermediate
and
most
contribute
newly
formed
reducing
number
steps
involved
waste
generated.
Molecular
iodine
is
mild,
efficient,
relatively
nontoxic,
inexpensive,
commercially
available,
catalyzes
various
organic
reactions
due
its
Lewis
acidic
behaviour.
The
development
catalyzed
by
molecular
indeed
good
green
alternative
for
synthetic
chemistry.
aim
this
article
review
all
important
reported
since
2013
order
envisage
some
new
efficient
protocols
synthesis
structurally
complex
molecules.
