Journal of Heterocyclic Chemistry,
Journal Year:
2024,
Volume and Issue:
61(7), P. 1180 - 1199
Published: May 21, 2024
Abstract
2‐Vinylanilines
are
readily
accessible
substrates,
which
undoubtedly
one
of
the
best
candidates
for
construction
diversely
nitrogen‐containing
heterocyclic
compounds.
Owing
to
amine
and
alkenyl
groups
in
their
structures,
these
frameworks
offer
a
facile,
direct,
selective
synthetic
method.
This
review
describes
various
cyclization
reactions
involving
2‐vinylanilines
catalyzed
by
transition
metals,
or
under
metal‐free
conditions.
Chemical Reviews,
Journal Year:
2022,
Volume and Issue:
122(24), P. 17479 - 17646
Published: Oct. 14, 2022
Alkenes
and
their
derivatives
are
featured
widely
in
a
variety
of
natural
products,
pharmaceuticals,
advanced
materials.
Significant
efforts
have
been
made
toward
the
development
new
practical
methods
to
access
this
important
class
compounds
by
selectively
activating
alkenyl
C(sp2)–H
bonds
recent
years.
In
comprehensive
review,
we
describe
state-of-the-art
strategies
for
direct
functionalization
sp2
C–H
C–F
until
June
2022.
Moreover,
metal-free,
photoredox,
electrochemical
also
covered.
For
clarity,
review
has
divided
into
two
parts;
first
part
focuses
on
currently
available
using
different
alkene
as
starting
materials,
second
describes
bond
easily
accessible
gem-difluoroalkenes
material.
This
includes
scope,
limitations,
mechanistic
studies,
stereoselective
control
(using
directing
groups
well
metal-migration
strategies),
applications
complex
molecule
synthesis
where
appropriate.
Overall,
aims
document
considerable
advancements,
current
status,
emerging
work
critically
summarizing
contributions
researchers
working
fascinating
area
is
expected
stimulate
novel,
innovative,
broadly
applicable
functionalizations
coming
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: Feb. 24, 2023
Photochemical
reactors
inherently
suffer
from
the
low
penetration
depth
of
light
and
therefore
rely
on
high
dilutions
to
enable
chemical
reactions.
Here
we
present
first
method
UV
(ultraviolet)
photochemistry
in
complete
absence
bulk
solvents
a
ball
mill.
Triphenylene
was
synthesized
by
two
routes,
Mallory
reaction
cyclodehydrochlorination
(CDHC),
resulting
yields
81
92
%,
respectively.
The
successfully
scaled
up
gram
scale
robustness
demonstrated
for
several
different
substrates.
Finally,
regioselective
assembly
nanographenes
mechanochemistry
larger
systems.
Thus,
mechanochemical
approach
presented
here
provides
powerful
new
tool
atomically
precise
construction
nanographenes.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(89), P. 12443 - 12446
Published: Jan. 1, 2022
Herein,
a
method
to
access
3-trifluoromethyl-1,4-benzoxazines
from
CF3-imidoyl
sulfoxonium
ylides
and
2-bromophenols
has
been
demonstrated.
This
synthetic
protocol
proceeds
via
one-pot
two-step
sequence
that
includes
the
lithium-bromide-promoted
O-H
insertion
of
annulation,
merits
broad
substrate
scope,
excellent
functional
tolerance
operational
simplicity,
which
provides
an
alternative
means
obtaining
CF3-substituted
heterocycles.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 3403 - 3412
Published: Feb. 8, 2024
A
practical
and
efficient
copper-catalyzed
carbocyclization
of
2-functionalized
anilines
with
ethyl
bromodifluoroacetate
has
been
developed.
Ethyl
is
employed
as
the
C1
source
via
quadruple
cleavage
in
this
transformation.
This
reaction
can
afford
a
variety
N-containing
heterocyclics
satisfactory
yields
excellent
functional
group
compatibility.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(39), P. 7148 - 7153
Published: Sept. 26, 2023
A
[Cp*IrCl2]2-catalyzed
amidocarbonation
of
olefins
with
sulfoxonium
ylides
has
been
developed
to
generate
diverse
biologically
important
isoindolin-1-ones
in
high
efficiency
under
mild
reaction
conditions.
Mechanism
studies
indicated
that
this
cascade
was
triggered
by
amino-iridation
the
olefin
unit
iridacycle,
followed
formal
migratory
insertion
ylides.
This
newly
method
features
broad
substrate
scopes
and
operational
simplicity.
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 458 - 472
Published: March 3, 2025
Photomechanochemistry,
i.e.,
the
merger
of
light
energy
and
mechanical
forces,
is
emerging
as
a
new
trend
in
organic
synthesis,
enabling
unique
reactivities
fleeting
excited
states
under
solvent-minimized
conditions.
Despite
its
transformative
potential,
field
faces
significant
technological
challenges
that
must
be
addressed
to
unlock
full
capabilities.
In
this
Perspective,
we
analyze
selected
examples
showcase
available
technologies
combine
including
manual
grinding,
vortex
shaker
mixing,
rod
milling,
ball
milling.
By
examining
advantages
limitations
each
approach,
aim
provide
an
overview
current
state
synthetic
photomechanochemistry
identify
opportunities
for
future
advancements
rapidly
evolving
area
research.
European Journal of Pharmaceutical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107097 - 107097
Published: April 1, 2025
Quinolines
have
been
an
interest
of
study
for
a
few
decades
due
to
the
importance
this
system
in
natural
and
pharmaceutical
products.
Since
their
discovery
nineteenth
century,
many
medicinal
properties
found
quinoline
compounds.
Firstly,
as
anti-parasitic
agent
against
malaria
then
other
diseases,
such
as,
parasitic
infections,
HIV,
bacterial
infections
cancer.
Consequently,
synthetic
methods
developed
afford
ring.
In
review
we
look
back
at
traditional
forward
most
recent
promising
"green"
synthesis
quinolines.
Also,
newest
advances
therapeutic
compounds
based
on
skeleton
treatment
cancer
diseases
applications
derivatives
drug
delivery
systems.
Catalysts,
Journal Year:
2025,
Volume and Issue:
15(5), P. 441 - 441
Published: April 30, 2025
Quinoline,
a
heterocyclic
scaffold
of
paramount
importance
in
medicinal
and
industrial
chemistry,
has
garnered
significant
attention
due
to
its
versatile
application.
Traditional
synthetic
methods,
dating
back
over
century,
have
evolved
into
innovative
strategies
leveraging
catalytic
C–H
bond
activation,
transition-metal-free
protocols,
photo-induced
oxidative
cyclization.
Recent
advancements
highlight
the
synergistic
roles
catalysts,
oxidants,
solvents
enhancing
molecular
reactivity
reaction
efficiency.
This
review
systematically
summarizes
state-of-the-art
annulation
techniques
for
quinoline
synthesis,
emphasizing
mechanistic
insights
practical
applications.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(39), P. 7095 - 7100
Published: Sept. 26, 2022
An
unprecedented
copper-catalyzed
cascade
reaction
of
1,6-enynes
with
sulfoxonium
ylides
is
reported,
providing
a
series
structurally
intriguing
2,3-disubstituted
indolines
bearing
conjugated
dienone
functionality
at
the
3-position
in
moderate
to
excellent
yields
good
chemo-,
regio-,
and
diastereoselectivities
under
mild
conditions.
Importantly,
sulfoxonium-ylide-derived
copper-carbene
herein
exhibits
quite
different
reactivity
from
that
diazo
copper-carbene.
A
rational
mechanism,
an
initial
ammonium
ylide
rather
than
allene
formation,
proposed.
