Facile Synthesis of Fully Substituted 1,2,4‐Triazoles via [3+2] Cycloaddition of Nitrileimines with Amidine under Transition Metal‐Free Conditions DOI
Dahan Wang,

Xiaoyuan Wan,

Yazheng Zhou

et al.

Asian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 15, 2022

Abstract An efficient synthesis of densely 1,2,4‐triazoles has been achieved by [3+2] cycloaddition nitrileimides with amidine hydrochlorides under transition metal‐free conditions. This method features mild reaction conditions, wide substrate scope and good functional group tolerance. A series aryl, heterocyclic alkyl substituted 3‐CF 3 ‐1,2,4‐triazoles were synthesized smoothly the promotion NaHCO yield up to 96%. In addition, both gram‐scale synthetic transformations are elaborated indicate utility this reaction.

Language: Английский

Recent Highlights in the Synthesis and Biological Significance of Pyrazole Derivatives DOI Creative Commons
Ziad Moussa, Mani Ramanathan,

Shaikha Mohammad Alharmoozi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38894 - e38894

Published: Oct. 1, 2024

Language: Английский

Citations

1
Solvent Dictated Organic Transformations DOI
Tamanna Khandelia, Pritishree Panigrahi, Subhendu Ghosh

et al.

Chemistry - An Asian Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Solvent plays an important role in many chemical reactions. The C-H activation has been one of the most powerful tools organic synthesis. These reactions are often assisted by solvents which not only provide a medium for but also facilitate reaching to product stage. solvent helps reaction profile both chemically and energetically reach targeted product. Organic transformations via from assistance perspective discussed this review. Various such as tetrahydrofuran (THF), MeCN, dichloromethane (DCM), dimethoxyethane (DME), 1,2-dichloroethane (1,2-DCE), dimethylformamide (DMF), dimethylsulfoxide (DMSO), isopropyl nitrile (

Language: Английский

Citations

1
Trapping in situ generated CF3-nitrile imines with maleimides under solvent-free mechanochemical conditions DOI Creative Commons
Greta Utecht‐Jarzyńska, Szymon Jarzyński, Marcin Jasiński

et al.

RSC Mechanochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A series of trifluoromethylated pyrrolo[3,4- c ]pyrazoles were obtained via mechanochemical (3 + 2)-cycloaddition in situ generated trifluoroacetonitrile imines with maleimide and its N -aliphatic/aromatic analogues.

Language: Английский

Citations

1
A zinc-catalyzed synthesis of 3-trifluoromethyl-4-trifluoroacetyl pyrazoles DOI

Biqiong Hong,

Xinzhi Ding,

Mengfan Jiang

et al.

Tetrahedron Letters, Journal Year: 2022, Volume and Issue: 104, P. 154018 - 154018

Published: July 15, 2022

Language: Английский

Citations

7
Facile Synthesis of Fully Substituted 1,2,4‐Triazoles via [3+2] Cycloaddition of Nitrileimines with Amidine under Transition Metal‐Free Conditions DOI
Dahan Wang,

Xiaoyuan Wan,

Yazheng Zhou

et al.

Asian Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 12(1)

Published: Dec. 15, 2022

Abstract An efficient synthesis of densely 1,2,4‐triazoles has been achieved by [3+2] cycloaddition nitrileimides with amidine hydrochlorides under transition metal‐free conditions. This method features mild reaction conditions, wide substrate scope and good functional group tolerance. A series aryl, heterocyclic alkyl substituted 3‐CF 3 ‐1,2,4‐triazoles were synthesized smoothly the promotion NaHCO yield up to 96%. In addition, both gram‐scale synthetic transformations are elaborated indicate utility this reaction.

Language: Английский

Citations

7