Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 13, 2024
2,3-Dihydrobenzofurans
are
noteworthy
scaffolds
in
organic
and
medicinal
chemistry,
constituting
the
structural
framework
of
many
varied
medicinally
active
compounds.
Moreover,
a
diverse
variety
biologically
potent
natural
products
also
contain
this
heterocyclic
nucleus.
Reflecting
on
wide
biological
substantiality
dihydrobenzofurans,
several
innovative
facile
synthetic
developments
evolving
to
achieve
these
heterocycles.
This
review
summarizes
transition-metal-free,
efficient,
novel
pathways
toward
constructing
dihydrobenzofuran
nucleus
established
after
2020.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 19, 2024
A
method
was
found
to
construct
sulfur-containing
five-
and
six-membered
heterocyclic
alkyl
sulfonyl
compounds
by
using
visible
light
free
radicals
activated
and/or
generated
EDA
complexes/homolytic
cleavage
as
initiators
stimulate
the
relay
reaction
of
alkynes/alkynones.
This
puts
forward
a
new
strategy
initiate
sulfonation
alkynes/alkynones
with
only
catalytic
amount
initiator.
generating
initiator
complex
activation/homolytic
provides
idea
for
following
substances
that
must
be
excited.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(23), P. 4823 - 4832
Published: Jan. 1, 2023
A
novel
visible-light
induced
sulfonylation/ipso-cyclization
of
N-arylpropiolamides
with
cyclobutanone
oxime
esters
and
Na2S2O5
was
reported.
This
protocol
proceeded
via
a
radical
process.
The
wide
substrate
scope,
sustainable
metal-free
conditions
readily
accessible
reagents
make
this
an
efficient
green
strategy
for
the
synthesis
cyanoalkyl
sulfonated
spiro[4,5]trienones.
Abstract
A
photocatalytic
methodology
has
been
devised
for
the
stereoselective
construction
of
trisubstituted
alkenes
incorporating
3,3‐difluoro‐γ‐lactams
in
17–93%
yields
via
a
radical
cascade
process
utilizing
MBH
acetates
and
N
‐allylbromodifluoroacetamides
as
starting
materials.
The
reaction
mechanism
involves
single‐electron
transfer,
5
‐
exo
trig
cyclization,
addition,
elimination
fashion.
Frontiers in Chemistry,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 13, 2024
2,3-Dihydrobenzofurans
are
noteworthy
scaffolds
in
organic
and
medicinal
chemistry,
constituting
the
structural
framework
of
many
varied
medicinally
active
compounds.
Moreover,
a
diverse
variety
biologically
potent
natural
products
also
contain
this
heterocyclic
nucleus.
Reflecting
on
wide
biological
substantiality
dihydrobenzofurans,
several
innovative
facile
synthetic
developments
evolving
to
achieve
these
heterocycles.
This
review
summarizes
transition-metal-free,
efficient,
novel
pathways
toward
constructing
dihydrobenzofuran
nucleus
established
after
2020.
