Synthetic Strategies Toward 2H‐, 4H‐Pyrans, and Pyranones: Recent Advances DOI

Subhasis Samai,

Sanghamitra Atta,

Maya Shankar Singh

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(21)

Published: May 30, 2025

Abstract Pyrans are a class of six‐membered heterocyclic rings containing five carbon atoms and one oxygen atom. They non‐aromatic in nature, bearing two double bonds the ring. The bond position distinguishes pyran isomers, namely, 2 H ‐pyran 4 ‐pyran. When saturated sp 3 is located next to an atom, it known as ‐pyran, when at 4‐position with respect In 1962, by thermal breakdown 2‐acetoxy‐3,4‐dihydro‐2 ‐pyrans were produced for first time, their characteristics explored. Numerous synthetic methods have been disclosed over time owing broad applications diverse fields, mainly drug design, pharmaceuticals, material science. this review, we highlight recent advancements toward substituted 4‐pyranone, 2‐pyranones, focusing on reports published from 2019 till date, which play important roles both organic synthesis types functional molecules.

Language: Английский

Synthesis of 4-Alkylated 1,4-Dihydropyridines: Fe(II)-Mediated Oxidative Cascade Cyclization Reaction of Cyclic Ethers with Enaminones DOI

Yulin Sun,

Zhuoyuan Liu, Donghan Liu

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(16), P. 11627 - 11636

Published: Aug. 9, 2023

Syntheses of highly functionalized 4-alkylated 1,4-dihydropyridines (1,4-DHPs) from cyclic ethers and enaminones via iron(II)-mediated oxidative free radical cascade C(sp3)-H bond functionalization/C(sp3)-O cleavage/cyclization reaction have been first developed. This novel synthetic strategy offers an alternative method for the construction 1,4-DHPs by using esters as C4 sources, well expands application in heterocycle synthesis.

Language: Английский

Citations

10

Copper(II)‐Catalyzed [2+2+2] Annulation of Enaminones with Maleimides Using a Traceless Directing Group Strategy DOI
Leiqing Fu, Hongxiang Huang, Yingying Jiang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(19), P. 4139 - 4144

Published: July 2, 2024

Abstract A copper‐catalyzed annulation of enaminones with maleimides was developed to synthesize various pyrrolo[3,4‐e]isoindoles. In this strategy, 2‐aminopyridine served as a traceless directing group, and target products were obtained in 54–72% yields. Moreover, plausible mechanism for reaction proposed based on several control experiments, deuterium exchange previous reports.

Language: Английский

Citations

3

Synthesis of C2-Spiroindolines Based on the Cascade Reaction of 2-Aryl-3H-indoles with Cyclopropanols DOI

Xueying Yang,

Yuanshuang Xu, Xinying Zhang

et al.

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(2), P. 694 - 694

Published: Jan. 1, 2025

Language: Английский

Citations

0

Rh-Catalyzed Enantioselective Synthesis of Acyclic Quaternary Carbons via Carbene Insertion DOI
Kun He,

Weikun Zeng,

Yingcheng Wang

et al.

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 5273 - 5282

Published: March 13, 2025

Language: Английский

Citations

0

Synthetic Strategies Toward 2H‐, 4H‐Pyrans, and Pyranones: Recent Advances DOI

Subhasis Samai,

Sanghamitra Atta,

Maya Shankar Singh

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(21)

Published: May 30, 2025

Abstract Pyrans are a class of six‐membered heterocyclic rings containing five carbon atoms and one oxygen atom. They non‐aromatic in nature, bearing two double bonds the ring. The bond position distinguishes pyran isomers, namely, 2 H ‐pyran 4 ‐pyran. When saturated sp 3 is located next to an atom, it known as ‐pyran, when at 4‐position with respect In 1962, by thermal breakdown 2‐acetoxy‐3,4‐dihydro‐2 ‐pyrans were produced for first time, their characteristics explored. Numerous synthetic methods have been disclosed over time owing broad applications diverse fields, mainly drug design, pharmaceuticals, material science. this review, we highlight recent advancements toward substituted 4‐pyranone, 2‐pyranones, focusing on reports published from 2019 till date, which play important roles both organic synthesis types functional molecules.

Language: Английский

Citations

0