Angewandte Chemie,
Journal Year:
2022,
Volume and Issue:
135(10)
Published: Dec. 28, 2022
Abstract
We
describe
here
the
development
of
a
visible
light
driven
nickel
carbonylation
catalyst.
The
combination
large
bite‐angle
Xantphos
ligand
with
nickel(0)
generates
catalyst
capable
activating
alkyl
halides
toward
at
ambient
temperature
in
presence
blue
irradiation,
and
reductive
elimination
high
energy
acid
chloride
products.
Unlike
classical
carbonylations,
where
coordination
carbon
monoxide
inhibits
reactivity
earth
abundant
catalysts,
CO‐associated
is
found
to
be
active
reaction.
Coupling
build‐up
chlorides
nucleophile
addition
can
used
access
various
amides,
esters
thioesters,
including
those
sterically
encumbered
substrates
or
metal‐reactive
functionalities.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(39)
Published: Oct. 1, 2024
Abstract
Herein
the
one‐pot
thioesterification
and
hydrothiolation
of
α
,
β
‐unsaturated
esters
with
aliphatic
thiols
was
reported
at
room
temperature.
The
mechanism
indirectly
revealed
which
thioester
intermediate.
advantages
this
method
included
transition‐metal‐free,
mild
conditions,
broad
substrate
scope
good
functional
group
tolerance.
On
other
hand,
temperature
also
developed.
Angewandte Chemie,
Journal Year:
2022,
Volume and Issue:
135(10)
Published: Dec. 28, 2022
Abstract
We
describe
here
the
development
of
a
visible
light
driven
nickel
carbonylation
catalyst.
The
combination
large
bite‐angle
Xantphos
ligand
with
nickel(0)
generates
catalyst
capable
activating
alkyl
halides
toward
at
ambient
temperature
in
presence
blue
irradiation,
and
reductive
elimination
high
energy
acid
chloride
products.
Unlike
classical
carbonylations,
where
coordination
carbon
monoxide
inhibits
reactivity
earth
abundant
catalysts,
CO‐associated
is
found
to
be
active
reaction.
Coupling
build‐up
chlorides
nucleophile
addition
can
used
access
various
amides,
esters
thioesters,
including
those
sterically
encumbered
substrates
or
metal‐reactive
functionalities.
