Tailor‐Made Pyrazolopyridines and Fused Pyrazolopyridines: Recent Updates toward Sustainable Synthesis

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(36)

Published: Sept. 1, 2024

Abstract Over the last three decades, owing to labour cost, time and especially environmental issues, one‐pot synthesis of heterocyclic compounds involving tandem or multicomponent (sequential consecutive) reactions has gained particular attention worldwide. Most marketed drug molecules hold one more rings. Due some side effects several drugs along with gradual emergence antimicrobial resistance, necessity for developing new continues; special should be paid in this respect towards employing their syntheses. Pyrazolopyridines are fused heterocycles holding pyridine pyrazole possess a wide variety biological pharmaceutical properties. Several existing also bear pyrazolopyridine scaffolds. The present perspective is an endeavour encompass green syntheses different isomeric systems, most these published during past five years few cases.

Language: Английский

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Organocatalytic Asymmetric [3 + 2] Cyclization: Enantioselective Synthesis of α-Indolyl Pyrrolo[1,2-a]indole Scaffolds

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

A novel asymmetric [3 + 2] cyclization of α-indolyl propargylic alcohols with 3-alkyl-1H-indoles via chiral phosphoric acid catalysis has been established. This strategy allowed the synthesis pyrrolo[1,2-a]indole derivatives high yields (up to 91%) and excellent enantioselectivities 99% ee), facilitating both reaction activity enantioselectivity by using solvent CH

Language: Английский

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Asymmetric Synthesis of Polycyclic Heterocyclic Compounds via Friedel–Crafts Reaction/Cyclization Reaction Catalyzed by Nickel Catalyst

Organic Letters, Journal Year: 2024, Volume and Issue: 26(46), P. 9877 - 9884

Published: Nov. 11, 2024

The first highly enantioselective asymmetric Friedel-Crafts reaction/cyclization reaction of 5-aminopyrazoles with 3-alkenyloxindoles to afford polycyclic heterocyclic compounds bearing an all-carbon quaternary stereocenter catalyzed by a complex Ni

Language: Английский

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Five-membered ring systems: with more than one N atom

Progress in heterocyclic chemistry, Journal Year: 2023, Volume and Issue: unknown, P. 281 - 332

Published: Jan. 1, 2023

Language: Английский

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