Synthesis,
Journal Year:
2023,
Volume and Issue:
56(13), P. 1967 - 1978
Published: Nov. 21, 2023
Abstract
The
absorption
of
light
by
photosensitizers
has
been
shown
to
offer
novel
reactive
pathways
through
electronic
excited
state
intermediates,
complementing
ground-state
mechanisms.
Such
strategies
have
applied
in
both
photocatalysis
and
photoredox
catalysis,
driven
generating
intermediates
from
their
long-lived
states.
One
developing
area
is
photoinduced
ligand-to-metal
charge
transfer
(LMCT)
which
coordination
a
ligand
metal
center
subsequent
excitation
with
results
the
formation
radical
reduced
center.
This
mini
review
concerns
foundations
recent
developments
on
transition-metal
focusing
organic
transformations
made
possible
this
mechanism.
1
Introduction
2
Iron
3
Cobalt
4
Nickel
5
Copper
6
Future
Outlook
Conclusion
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2381 - 2386
Published: March 15, 2024
Organic
sulfones
are
an
important
class
of
chemical
compounds
widely
used
in
many
research
fields.
The
direct
decarboxylative
sulfonylation
carboxylic
acids
is
attractive
but
challenging,
particularly
when
iron
as
a
metal
catalyst.
Herein,
we
describe
photoinduced
iron-catalytic
method
for
the
synthesis
directly
using
via
radical-based
decarboxylation.
This
protocol
mild,
highly
efficient,
and
easy-to-operate.
A
broad
scope
carbon
electrophiles
could
be
well
tolerated.
mechanism
involving
iron-catalyzed
decarboxylation,
radical
transfer,
single-electron
reduction,
nucleophilic
attack
proposed.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(6), P. 1729 - 1735
Published: Jan. 1, 2024
An
iron-catalyzed
fragmentation
alkynylation,
alkenylation
and
alkylation
enabled
by
photoinduced
ligand-to-metal
charge
transfer
(LMCT)processis
herein
reported.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(34), P. 23923 - 23932
Published: Aug. 16, 2024
The
strategic
incorporation
of
fluorine
atoms
into
molecules
has
become
a
cornerstone
modern
pharmaceuticals,
agrochemicals,
and
materials
science.
Herein,
we
have
developed
covalent
organic
framework
(COF)-based,
robust
photocatalyst
that
enables
the
photofluorodecarboxylation
reaction
diverse
carboxylic
acids,
producing
alkyl
fluorides
with
remarkable
efficiency.
catalytic
activity
an
anthraquinone-based
COF
catalyst
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
A
visible-light-driven
Se/Fe
synergistic
catalytic
reaction
between
isocyanides
and
amines
has
been
developed,
employing
air
as
the
terminal
oxidant.
This
efficient
strategy
offers
facile
access
to
2-aminoquinoline
scaffolds.
The
use
of
cost-effective
readily
available
Fe(OTf)3
modulates
selenium
catalyst's
oxidation
state,
enhancing
method's
environmental
friendliness
practicality.
protocol
is
further
distinguished
by
its
good
yields,
broad
substrate
scope,
mild
conditions.
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(21), P. 8741 - 8747
Published: Jan. 1, 2023
An
efficient
photo-triggered
halodecarboxylation
reaction
of
aliphatic
carboxylic
acids
for
the
preparation
bromo-,
iodo-
and
chloroalkanes
under
an
air
atmosphere
with
water
as
solvent
has
been
developed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(10), P. 2029 - 2033
Published: March 4, 2024
Herein,
we
report
an
efficient
photoinduced
iron-catalyzed
strategy
for
cross-couplings
of
alkyl
carboxylic
and
acrylic
acids,
which
provides
a
powerful
tool
the
synthesis
variety
alkenes
with
polar
functional
groups.
This
novel
synthetic
methodology
can
also
be
applied
to
preparation
ketones
by
using
α-keto
acids.
Mechanistic
experiments
revealed
preliminary
mechanistic
details.
Diverse
functionalization
could
achieved,
may
help
streamline
complex
analogues
drug
discovery.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(32)
Published: May 13, 2024
Abstract
We
report
an
iron‐catalyzed
decarboxylative
C(sp
3
)−O
bond‐forming
reaction
under
mild,
base‐free
conditions
with
visible
light
irradiation.
The
transformation
uses
readily
available
and
structurally
diverse
carboxylic
acids,
iron
photocatalyst,
2,2,6,6‐tetramethylpiperidine
1‐oxyl
(TEMPO)
derivatives
as
oxygenation
reagents.
process
exhibits
a
broad
scope
in
acids
possessing
wide
range
of
stereoelectronic
properties
functional
groups.
developed
was
applied
to
late‐stage
series
bio‐active
molecules.
leverages
the
ability
complexes
generate
carbon‐centered
radicals
directly
from
by
photoinduced
carboxylate‐to‐iron
charge
transfer.
Kinetic,
electrochemical,
EPR,
UV/Vis,
HRMS,
DFT
studies
revealed
that
TEMPO
has
triple
role
reaction:
reagent,
oxidant
turn
over
Fe‐catalyst,
internal
base
for
acid
deprotonation.
obtained
adducts
represent
versatile
synthetic
intermediates
were
further
engaged
C−C
C‐heteroatom
reactions
using
commercial
organo‐photocatalysts
nucleophilic
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
25(2), P. 560 - 565
Published: Jan. 1, 2023
An
operationally
simple
method
providing
access
to
valuable
chlorinated
organic
backbones
is
reported.
The
transformation
transpires
via
a
sustainable
photoinduced
halodecarboxylative
halogen-atom
transfer
protocol.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(19), P. 2779 - 2782
Published: Jan. 1, 2023
N
-Iodosuccinimide
catalyzed,
visible-light-induced
oxidative
decarboxylative
cross-coupling
between
cinnamic
acids
and
NH-sulfoximines
leading
to
α-keto-
-acyl
sulfoximines
is
presented.
