Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(24)
Published: Nov. 20, 2023
Abstract
A
novel
palladium‐catalyzed
three‐component
carbonylation
reaction
for
the
assembly
of
various
1,3‐substituted
maleimide
derivatives
from
haloalkynes
and
simple
anilines.
The
nucleophilic
addition
haloalkynes,
anilines
CO,
insertion
carbonyl
have
been
achieved
sequentially
in
this
reaction.
high
chemo‐
regioselectivities,
as
well
no
need
expensive
ligands
or
additives
further
illustrate
synthetic
value
approach.
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
Abstract
A
novel
bismuth(III)
trifluoro‐methanesulfonate‐catalyzed
and
environmentally
benign
synthetic
strategy
for
the
construction
of
a
wide
range
structurally
diverse,
sophisticated
[5,6,5]‐oxygen‐containing
tricyclic
frameworks
with
easy‐to
handle
propargylic
alcohols
2‐allylphenols
as
substrates
in
presence
Bi(OTf)
3
AgOTf
is
described.
This
Lewis
acid
catalyzed
[3+2]
annulation
protocol,
which
tolerates
great
deal
functional
groups,
proceeds
through
sequential
Meyer‐Schuster
rearrangement,
nucleophilic
substitution,
5‐
exo
‐trig
cyclization,
endo
proton
exchange
sequences,
affording
versatile
approach
accessing
oxygen‐containing
skeletons
moderate‐to‐excellent
yields.
In
addition,
most
obtained
compounds
exhibited
anti‐tumor
activities
against
three
types
human
cancer
cell
lines
vitro
,
including
Caco‐2
colon
cells,
MCF‐7
breast
Hepg‐2
liver
cells.
Chemistry - An Asian Journal,
Journal Year:
2023,
Volume and Issue:
18(24)
Published: Nov. 20, 2023
Abstract
A
novel
palladium‐catalyzed
three‐component
carbonylation
reaction
for
the
assembly
of
various
1,3‐substituted
maleimide
derivatives
from
haloalkynes
and
simple
anilines.
The
nucleophilic
addition
haloalkynes,
anilines
CO,
insertion
carbonyl
have
been
achieved
sequentially
in
this
reaction.
high
chemo‐
regioselectivities,
as
well
no
need
expensive
ligands
or
additives
further
illustrate
synthetic
value
approach.
