Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1546 - 1546
Published: Dec. 2, 2024
The
review
examines
recent
advances
in
the
design
and
synthesis
of
1,3-selenazole
derivatives
since
2000.
Various
synthetic
approaches
to
1,3-selenazoles
reaction
conditions
are
discussed.
beneficial
properties
1,3-selenazoles,
especially
their
biological
activity,
emphasized.
Compounds
with
antitumor,
antiviral
(HIV-1
HIV-2),
antibacterial,
antifungal,
antiproliferative,
anticonvulsant,
antioxidant
activity
highlighted.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(25), P. 5263 - 5268
Published: June 14, 2024
A
green
and
sustainable
electrochemical
oxidative
cyclization
of
enaminones
with
thioamides
under
metal-
oxidant-free
conditions
has
been
developed,
providing
an
efficient
approach
for
thiazole
synthesis.
Furthermore,
1,2,4-thiadiazoles
can
be
selectively
accessed
via
the
dimerization
in
absence
enaminones.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(23), P. 4286 - 4291
Published: June 2, 2023
Two
categories
of
tetrasubstituted
phenols
were
prepared
via
the
cycloaddition
reaction
vinyl
sulfoxonnium
ylides
with
cyclopropenones
in
a
switchable
manner.
Copper
carbenoid
was
proposed
as
active
intermediate
process
2,3,4,5-tetrasubstituted
formation,
while
2,3,5,6-tetrasubstituted
generated
direct
[3
+
3]
annulation
under
metal-free
conditions.
Further
synthetic
applications
also
demonstrated.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(11), P. 3234 - 3241
Published: Jan. 1, 2024
Herein,
we
present
a
cascade
O–H
double
insertion
reaction
between
I
(III)
/S
(VI)
-ylides,
carboxylic
acids,
and
alcohols
under
metal-free
conditions,
enabling
the
modular
synthesis
of
unsymmetrical
α,α-
O
,
-substituted
ketones.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(27), P. 5811 - 5816
Published: June 28, 2024
A
practical
strategy
for
the
construction
of
diverse
phosphonyl
and
thiofunctionalized
sulfoxonium
ylides
via
controllable
monofunctionalization
hybrid
I(III)/S(VI)
is
presented.
This
process
allows
efficient
P–H
insertion
under
Cu
catalysis,
enabling
synthesis
ylides,
whereas
reaction
with
sulfur-containing
reagents
including
AgSCF3,
KSC(S)OR,
KSCN
mild
conditions
resulted
in
α-trifluoromethylthiolation,
dithiocarbanation,
thiocyanation
accordingly.
Of
note,
wide
substrate
compatibility
(108
examples),
excellent
efficiency
(up
to
99%
yield),
gram-scale
experiments,
various
product
derivatizations
highlight
synthetic
utility
this
protocol.
Synthesis,
Journal Year:
2024,
Volume and Issue:
56(16), P. 2565 - 2571
Published: April 26, 2024
Abstract
Visible-light
photocatalytic
reactions
between
enaminones
and
thioureas
leading
to
thiazole
products
have
been
achieved.
The
annulation
process
consists
of
tandem
C–S
C–N
bond
formation
by
running
under
air
atmosphere
at
ambient
temperature.
Broad
substrate
tolerance
the
sustainable
protocol
has
verified
practical
synthesis
divergent
thiazoles
with
both
monocyclic
fused
cyclic
structures.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(68), P. 10247 - 10250
Published: Jan. 1, 2023
Efficient,
versatile,
and
metal-free
strategies
for
synthesizing
α-thiocyanoketones
thiazoles
from
β-ketosulfoxonium
ylides
ammonium
thiocyanate
have
been
described.
Due
to
its
simplicity,
benign
reaction
conditions,
excellent
chemoselectivity,
high
yield,
this
method
represents
a
unique
approach
divergent
synthesis.
Finally,
the
potential
value
of
developed
methods
is
demonstrated
via
large-scale
reactions
synthesis
Fanetizole,
an
anti-inflammatory
drug.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
The
rare
[1,2]-sigmatropic
rearrangement
of
sulfoxonium-iodonium
hybrid
ylides
is
described,
which
enables
the
efficient
sulfoxidation/sulfonylation-alkylation
I(III)/S(VI)
with
1,3-dicarbonyls.
By
slight
modification
reaction
conditions,
controllable
alkylation-hydroxylation
and
dialkylation
were
achieved.
This
strategy
affords
a
diverse
array
α,α-difunctionalized
ketones
in
moderate
to
good
yields,
demonstrating
broad
substrate
scope.
These
findings
provide
an
important
advancement
sulfoxonium
highlight
divergent
reactivity
ylides.
Industrial & Engineering Chemistry Research,
Journal Year:
2023,
Volume and Issue:
62(32), P. 12513 - 12529
Published: Aug. 4, 2023
We
evaluated
natural
clay
minerals
representing
all
classes
of
phyllosilicates
as
in
situ
catalysts
for
hydrothermal
liquefaction
(HTL)
anaerobically
digested
cattle
manure
at
350
°C
1
h,
i.e.,
kaolinite,
montmorillonite,
talc,
vermiculite,
phlogopite,
meixnerite,
attapulgite,
and
alumina.
The
relative
compositions
strong
Bronsted
(SBrA),
Lewis
(SLA),
weak
acidic
(WLA)
sites
the
(SBS)
(WBS)
basic
significantly
affected
formation
HTL
products
(i.e.,
biocrude
oil,
hydrochar,
aqueous-
gas-phase
coproducts)
distribution
speciation
elements.
general
mechanistic
roles
these
active
are
follows:
(1)
SBrA
catalyzed
biocrude-forming
reactions
inhibited
hydrochar-repolymerizing
reactions;
(2)
SLA
promoted
production
hydrochar
precursors;
(3)
WLA
enhanced
hydrodeoxygenation,
hydrodenitrogenation,
hydrodesulfurization
by
utilizing
hydrogen
generation
WBS;
(4)
SBS
increased
organic
acids
solubilizing
nutrients
into
aqueous-phase
coproduct
(HTL-AP).
Montmorillonite
was
most
suitable
catalyst
due
to
optimal
composition
sites,
leading
achieving
maximal
energy
recovery
82%)
with
low
heteroatoms
content
15%
O,
0.24%
N,
0.08%
S),
minimal
yield
10%),
nutrient
HTL-AP,
71%
P,
54%
Mg,
29%
NH3-N,
14%
Ca.
In
addition,
crystalline
structure
montmorillonite
remained
intact
after
process.
This
study
informs
comprehensive
catalytic
different
surface-active
useful
future
development
clay-based
more
sustainable
overall
systems.
