Synthesis,
Journal Year:
2023,
Volume and Issue:
56(11), P. 1727 - 1734
Published: Dec. 19, 2023
Abstract
The
incorporation
of
sulfonyl
fluoride
groups
into
molecules
has
been
proven
effective
in
enhancing
their
biological
activities
or
introducing
new
functions.
Herein,
a
transition-metal-free
and
visible-light-mediated
radical
tandem
cyclization
unsaturated
carboxylic
acid
is
reported.
This
affords
facile
access
to
FSO2-functionalized
γ-lactones
efficiently,
which
are
critical
structural
motifs
widely
present
biologically
active
molecules.
JACS Au,
Journal Year:
2023,
Volume and Issue:
3(11), P. 3045 - 3054
Published: Nov. 14, 2023
The
rise
of
interest
in
using
polycyclic
aromatic
hydrocarbons
(PAHs)
and
molecular
graphenoids
optoelectronics
has
recently
stimulated
the
growth
modern
synthetic
methodologies
giving
access
to
intramolecular
aryl-aryl
couplings.
Here,
we
show
that
a
radical-based
annulation
protocol
allows
expansion
planarization
approaches
prepare
functionalized
graphenoids.
enabler
this
reaction
is
peri-xanthenoxanthene,
photocatalyst
which
undergoes
photoinduced
single
electron
transfer
with
an
ortho-oligoarylenyl
precursor
bearing
electron-withdrawing
nucleofuge
groups.
Dissociative
enables
formation
persistent
aryl
radical
intermediates,
latter
undergoing
C-C
bond
formation,
allowing
occur.
conditions
are
mild
compatible
various
-donating
substituents
on
rings
as
well
heterocycles
PAHs.
method
could
be
applied
induce
double
reactions,
synthesis
π-extended
scaffolds
different
edge
peripheries.
Current Topics in Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
25(1), P. 124 - 140
Published: July 4, 2024
Visible-light-mediated
reactions
have
recently
emerged
as
a
powerful
strategy
for
the
synthesis
of
diverse
organic
molecules
under
mild
reaction
conditions.
Usually,
are
performed
at
room
temperature
and
thus
sensitive
functional
groups
remain
unaffected.
Thus,
this
protocol
has
received
intense
interest
from
academia
well
industries.
The
heterocycles,
in
general,
much
because
their
biological
activities
application
therapeutics.
Oxygen-
Sulfur-containing
heterocyclic
compounds
attracted
attention
these
showed
promising
anti-cancer
drugs,
antibiotics,
antifungal
anti-inflammatory
agents
among
other
applications.
class
by
efficient
greener
routes
become
an
important
target.
This
review
highlights
various
procedures
derivatives
visible
light-induced
reactions.
green
aspects
mechanism
each
procedure
been
discussed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(20), P. 4292 - 4296
Published: May 10, 2024
Here,
we
report
a
practical
route
to
medicinally
interesting
lycorine
congeners
alongside
formal
syntheses
of
various
lycorine-type
natural
products,
including
itself.
The
efficiency
our
strategy
derives
from
back-to-back
5-endo-trig/6-endo-trig
radical
cyclization
sequence,
which
systematically
studied
both
experimentally
and
computationally.
results
work
will
facilitate
future
development
urgently
needed
antiviral
therapeutics
based
on
lycorine.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 3, 2024
Abstract
Herein,
we
report
the
development
of
a
FSO2
radical
initiated
tandem
cyclization
reaction
under
visible
light
photoredox
catalysis,
which
allows
for
facile
access
to
FSO2-functionalized
oxindoles
from
N-arylacrylamides.
This
features
mild
conditions,
readily
available
starting
materials,
and
SuFExable
products.
The
introduction
sulfonyl
fluoride
groups
into
could
be
interest
related
study
in
context
discovering
new
bioactive
molecules.
Synthesis,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Abstract
Sulfur(VI)
fluoride
exchange
(SuFEx)
chemistry
that
relies
on
the
unique
reactivity–stability
balance
of
high
valent
organosulfur
has
emerged
as
a
promising
topic
for
next-generation
click
reaction.
Sulfonyl
fluorides
are
most
widely
used
connective
hubs
SuFEx
reaction
with
widespread
applications
in
fields
chemical
biology,
drug
discovery,
and
materials
science.
Compared
current
methods,
direct
fluorosulfonylation
fluorosulfonyl
radicals
concise
efficient
approach
production
sulfonyl
fluorides.
The
highly
active
SO2F
radical
was
an
unstable
inaccessible
precursor
until
it
observed
decomposition
azide,
which
inspired
efforts
towards
precursors
processes.
This
review
presents
discusses
breakthroughs
generation
from
various
precursors,
well
their
application
synthesis
diverse
functionalized
1
Introduction
2
FSO2Cl
Radical
Precursor
3
Benzimidazolium
Fluorosulfonates
Precursors
4
Alk-1-ynylsulfonyl
Fluorides
5
(Diarylmethylene)sulfamoyl
6
Vinyl
Fluorosulfates
7
Conclusion
Outlook
Synthesis,
Journal Year:
2023,
Volume and Issue:
56(11), P. 1727 - 1734
Published: Dec. 19, 2023
Abstract
The
incorporation
of
sulfonyl
fluoride
groups
into
molecules
has
been
proven
effective
in
enhancing
their
biological
activities
or
introducing
new
functions.
Herein,
a
transition-metal-free
and
visible-light-mediated
radical
tandem
cyclization
unsaturated
carboxylic
acid
is
reported.
This
affords
facile
access
to
FSO2-functionalized
γ-lactones
efficiently,
which
are
critical
structural
motifs
widely
present
biologically
active
molecules.
