Three-component synthesis ofN-naphthyl pyrazolesviaRh(iii)-catalyzed cascade pyrazole annulation and Satoh–Miura benzannulation

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(27), P. 4036 - 4039

Published: Jan. 1, 2023

The synthesis of N-naphthyl pyrazoles has been realized by the direct three-component reactions enaminones, aryl hydrazine hydrochlorides and internal alkynes via Rh(III) catalysis. synthetic employing simple substrates lead to simultaneous construction dual cyclic moieties, including a pyrazole ring phenyl ring, sequential formation two C-N three C-C bonds.

Language: Английский

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Palladium-catalyzed regio- and stereo-selective phosphination of cyclic biarylsulfonium salts to access atropoisomeric phosphines

Chemical Science, Journal Year: 2024, Volume and Issue: 15(18), P. 6943 - 6948

Published: Jan. 1, 2024

A Pd-catalyzed atroposelective phosphination of cyclic biarylsulfonium salts with HPAr 3 Ar 4 for straightforward synthesis chiral phosphines bearing a stereogenic axis or both and P-stereogenic center is reported.

Language: Английский

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An Unexpected [3 + 2]-Cycloaddition between Spiro-Epoxyoxindoles and γ-Deconjugated Butenolides Catalyzed by Sc(OTf)₃

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

A unique β-position [3 + 2]-cycloaddition between γ-deconjugated butenolides and spiro-epoxyoxindoles catalyzed by Sc(OTf)3 has been disclosed. variety of unexpected adducts spiro-oxindoles fused with bicyclic γ-lactones three consecutive stereocenters have successfully constructed in good yields (up to 88%) excellent diastereoselectivities (>20:1) one single operation under mild conditions, which is difficult achieve traditional strategies.

Language: Английский

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Recent advances in direct asymmetric reaction of furanone

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134627 - 134627

Published: March 1, 2025

Language: Английский

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A Unified Strategy for the Synthesis of Diverse Bicyclo[2.2.2]octadiene Ligands

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

A new approach for the enantioselective synthesis of various bicyclo[2.2.2]octadiene ligands has been developed, which features a chiral oxazaborolidinium-catalyzed asymmetric Diels-Alder reaction to construct bicyclo[2.2.2]octane framework. The pivotal ketone 12 served as common intermediate that was finally transformed into desired C1- and C2-symmetric dienes. This work provides an alternative method reported diene would be beneficial exploration potentials this type versatile ligand in transformations.

Language: Английский

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Rhodium-Catalyzed Asymmetric Conjugate Addition to γ-Substituted α,β-Unsaturated γ-Lactams through Dynamic Kinetic Resolution: Asymmetric Synthesis of trans-β,γ-Disubstituted γ-Lactams

ACS Catalysis, Journal Year: 2023, Volume and Issue: 13(10), P. 6603 - 6609

Published: April 28, 2023

The reaction of racemic γ-substituted α,β-unsaturated γ-lactams rac-1 with arylboron reagents 2 in the presence a chiral diene L1a–rhodium catalyst under basic conditions (3.0 equiv NEt3) gave high yields β,γ-disubstituted trans-γ-lactams 3 both diastereo- and enantioselectivity. Fast racemization 1 by way dienolate generated base followed kinetic resolution rhodium realized this highly efficient dynamic resolution. synthetic utility present method is demonstrated synthesis key intermediates to biologically active compounds.

Language: Английский

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Lewis Acid-catalyzed Regioselective Addition of Allenoates to Indoles for Synthesis of Bisindolylesters

Chemical Research in Chinese Universities, Journal Year: 2024, Volume and Issue: unknown

Published: July 17, 2024

Language: Английский

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