Prayogik Rasayan,
Journal Year:
2023,
Volume and Issue:
7(1)
Published: Jan. 1, 2023
In
recent
years,
organic
photo-redox
catalysts
such
as
Ru
or
Ir-metal
complexes
and
dyes
have
expanded
the
traditional
catalytic
toolbox
due
to
their
sustainability
environment
friendliness.
The
central
focus
of
this
review
is
explore
unconventional
photo-catalysts
activity
in
transformations.
However,
an
overview
unorthodox
has
been
demonstrated
herein
illuminate
photocatalytic
space
synthesis.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
We
herein
introduce
an
electrochemical
imino-pinacol
coupling
reaction
to
access
the
vicinal
diamine
scaffold.
This
green
and
convenient
protocol
employs
in
situ-generated
imines
as
starting
materials
deliver
a
broad
range
of
products
under
electroreductive
conditions.
Moreover,
this
is
also
applicable
pinacol
coupling.
Mechanistic
investigation
suggests
that
Mn(III)
additive
essential
for
promoting
SET
reduction
imine
material
preventing
formation
over-reduced
amine
side
product.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
In
the
quest
for
developing
catalysts
with
multiple
active
sites,
we
designed
a
series
of
methionine-based
peptide
prepared
by
classical
coupling.
Given
widespread
presence
aromatic
chloro-substituents
and
their
significant
pharmacokinetic
properties,
performance
these
were
evaluated
late-stage
chlorination
tyrosine
residue
on
peptides
up
to
octamer
as
well
drug
molecules.
The
operationally
simple
reaction
conditions,
excellent
catalyst
loading
0.25
mol
%,
gram-scale
reactions
are
major
highlights
this
method.
Chemical Science,
Journal Year:
2023,
Volume and Issue:
14(35), P. 9526 - 9532
Published: Jan. 1, 2023
Visible-light
photoredox
catalysis
is
well-established
as
a
powerful
and
versatile
organic
synthesis
strategy.
However,
some
substrate
classes,
despite
being
attractive
precursors,
are
recalcitrant
to
single-electron
redox
chemistry
thus
not
very
amenable
approaches.
Among
these
carbonyl
derivatives,
e.g.
ketones,
aldehydes,
imines,
which
in
most
cases
require
Lewis
or
Brønsted
acidic
additives
activate
via
photoinduced
electron
transfer.
In
this
work,
we
unveil
range
of
transformations
on
ketones
enabled
by
strongly
reducing
photosensitizers
operating
under
simple,
general
conditions
with
single
sacrificial
reductant
no
additives.
Specific
reactions
described
here
umpolung
C-C
bond
forming
between
aromatic
imines
electron-poor
alkenes,
imino-pinacol
homocoupling
challenging
alkyl-aryl
imine
substrates,
γ-lactonization
methyl
acrylate.
The
all
initiated
transfer
form
ketyl
iminyl
that
subsequently
trapped.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(6)
Published: Jan. 8, 2024
Abstract
A
method
for
the
generation
of
tertiary
carbanions
via
a
deaminative
radical‐polar
crossover
is
reported
using
redox
active
imines
from
α‐tertiary
primary
amines.
variety
benzylic
amines
and
amino
esters
can
be
used
in
this
approach,
with
latter
engaging
novel
“aza‐Reformatsky”
reaction.
Electronic
trends
correlate
stability
resulting
carbanion
reaction
efficiency.
The
anions
trapped
different
electrophiles
including
aldehydes,
ketones,
imines,
Michael
acceptors,
H
2
O/D
O.
Selective
anion
formation
achieved
presence
another
equivalent
or
more
acidic
C−H
bond
both
an
inter‐
intramolecular
fashion.
Mechanistic
studies
suggest
intermediacy
discrete
intermediate.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(13), P. 2211 - 2217
Published: June 10, 2023
Abstract
Enyne
diesters
derived
from
biaryls
and
related
substrates
undergo
intramolecular
[2+2]‐cycloaddition
concomitant
cyclo‐reversion
when
treated
with
10
mol%
In(OTf)
3
in
1,2‐dichloroethane.
This
enyne
metathesis
type
cycloisomerization
reaction
enables
the
synthesis
of
phenanthrene,
benzophenanthrene,
benzotetraphene
other
polycyclic
(hetero)aromatic
compounds
bearing
a
synthetically
useful
diethyl
β‐(hetero)arylidene
malonate
moiety
step‐
atom‐economic
manner.
‐catalyzed
two
independent
on
5
b
provides
direct
access
to
benzotetraphenes
6
containing
bis(diethyl
β‐phenylmethylene
malonate)
moiety.
Tetrasubstituted
vinylidene
4
,
substiututed
by
different
aromatic
groups,
is
stereoselectively
converted
into
E
‐
Z
‐isomer
triaryl
group
all
carbon
tetrasubstituted
olefins
(
8
a′
)
via
Pd‐catalyzed
stereoselective
decarboxylative
arylation
reaction.
Asian Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
13(4)
Published: Jan. 16, 2024
Abstract
A
visible‐light‐mediated
decarboxylative
oxidation
of
benzylic
redox
active
esters
is
described.
diverse
array
aromatic
ketones
or
aldehydes
could
be
achieved
(15
examples)
from
secondary
primary
aliphatic
carboxylic
acids.
mechanism
involving
resonance
transformation
in
the
presence
Cs
2
CO
3
proposed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(36), P. 7718 - 7722
Published: Sept. 5, 2024
Metal-free
photoredox
catalysts
built
upon
a
pyrene
core
were
developed
for
carbon-carbon
bond-forming
reactions.
Among
these
catalysts,
derivative
containing
urea
moiety
effectively
facilitated
the
reductive
coupling
of
aromatic
carbonyl
and
imine
compounds
under
blue
LED
irradiation.
This
process
provided
corresponding
vicinal
diols
diamines
in
good
yields.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(23), P. 16292 - 16301
Published: Nov. 18, 2023
The
potential
of
CdSe,
CdS,
MoS2,
and
WS2
QDs
as
semiconductor
photocatalysts
for
selective
functionalization
the
xanthene
9H
position
through
carbon-carbon
bond
formation
has
been
investigated.
Our
study
reveals
valuable
insights
into
energy-transfer
electron-transfer
pathways
involved
in
these
reactions,
well
radical
polar
crossover
(RPC)
triplet-to-triplet
energy
transfer
(TTEnT)
processes.
Notably,
this
approach
offers
a
range
intriguing
features,
including
visible-light-mediated
processes,
inexpensive
catalytic
systems,
mild
reaction
conditions,
broad
substrate
scope,
unfunctionalized
starting
materials,
suitability
gram-scale
synthesis.
This
makes
significant
contribution
to
newly
emerging
field
QD-catalyzed
paving
way
future
explorations.
