Diastereoselective Construction of Spirocyclic Isobenzofurans via a Tandem Michael Addition/5-Exo-dig Cyclization Reaction DOI

Shaghayegh Mehdidoust,

Saideh Rajai‐Daryasarei,

S. Sina Hosseini

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16613 - 16621

Published: Oct. 31, 2024

A practical approach for rapid and efficient access to spirocyclic isobenzofurans is described. The reaction proceeds through the cycloaddition of 1,6-ynenone derivatives 4-nitro-1,3-diarylbutan-1-ones, promoted by Cs

Language: Английский

EMM-Promoted Pd-Catalyzed Solid State Intramolecular Heck-Type Cyclization/Boronation and Suzuki Couplings: Access to Functionalized Indolines DOI

Yuwei Jia,

Hui Wang,

Jintao Guo

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(10), P. 6704 - 6713

Published: May 6, 2024

EMM (electromagnetic mill)-promoted Pd-catalyzed solid state intramolecular Heck-type cyclization/boronation and Suzuki couplings are reported. Compared to previous mechanochemistry that constructed one chemical bond through a cross-coupling reaction, this strategy realizes cascade transformation along with multiple formation. This conversion does not require organic solvents or additional heating, it shows good substrate scope high functional group tolerance.

Language: Английский

Citations

0
α-Carbonyl Rh-Carbenoid Initiated Cascade Assembly of Diazobarbiturates with Alkylidene Pyrazolones for Synthesis of Spirofuropyrimidines DOI Creative Commons
Yue Zhang,

Yu‐Hang Mi,

Kuo Wang

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3178 - 3178

Published: July 3, 2024

Catalyzed by Rh2(esp)2 (10 mol%) and (±)-BINAP (20 in DCE at 80 °C, the cascade assembly between diazobarbiturates alkylidene pyrazolones proceeded readily produced spiro-furopyrimidines 38–96% chemical yields. The structure of prepared spirofuro-pyrimidines was firmly confirmed X-ray diffraction analysis.

Language: Английский

Citations

0
Synthesis of branched and linear aryl allylic alcohols: C H bond allylation of 2-aryl-3H-indoles with vinyl cyclic carbonates DOI
Fan Yu, Bin Li, Xinying Zhang

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 147, P. 155225 - 155225

Published: Aug. 4, 2024

Language: Английский

Citations

0
Diazo‐Based Construction of Heterocyclic Systems Via a X−H Insertion/Cyclization Cascade DOI Open Access
Ksenia Malkova, Dmitry Dar’in

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract The X−H insertion reaction (X=heteroatom) of diazo compounds has emerged as an eminent and reliant approach for the construction C−X bonds. By merging with sequential ring‐closing transformations, diverse heterocyclic systems can be obtained in a step‐economical manner. In recent years, insertion/cyclization cascades one‐pot transformations attract more research attention, especially area asymmetric synthesis. Concentrating on assembly N,O,S‐heterocycles, this Concept elucidates various combinations reactions cyclization via addition to multiple ring‐forming strategies reviewed comprise Michael‐type Conia‐ene reactions, aldol condensation, Mannich reaction.

Language: Английский

Citations

0
Diastereoselective Construction of Spirocyclic Isobenzofurans via a Tandem Michael Addition/5-Exo-dig Cyclization Reaction DOI

Shaghayegh Mehdidoust,

Saideh Rajai‐Daryasarei,

S. Sina Hosseini

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(22), P. 16613 - 16621

Published: Oct. 31, 2024

A practical approach for rapid and efficient access to spirocyclic isobenzofurans is described. The reaction proceeds through the cycloaddition of 1,6-ynenone derivatives 4-nitro-1,3-diarylbutan-1-ones, promoted by Cs

Language: Английский

Citations

0