Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
Electrolysis
of
o-alkynyl-N-(formyl)anilides
and
sodium
sulfinates
on
graphite
electrodes
delivers
biologically
sound
3-(sulfonyl)quinol-4-ones
with
moderate
to
good
yields.
The
reaction
is
carried
out
in
an
undivided
cell
the
presence
silver(I)
oxide
potassium
iodide
or
tetrafluoroborate
as
supporting
electrolyte.
tolerates
variously
substituted
anilides
well
aryl
alkyl
sulfinates.
transformation
proceeds
a
domino
sequence
oxysulfonylation
cyclocondensation
steps.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 2873 - 2884
Published: Feb. 14, 2024
We
have
developed
the
first
I2/base-catalyzed
regio-
and
stereoselective
intermolecular
β-amidosulfonylation
of
terminal
alkynes
using
sodium
sulfinates
quinoxalinone
derivatives.
The
present
methodology
is
compatible
with
a
broad
spectrum
various
heterocyclic
amides,
alkynes,
sulfinates.
It
provides
rapid
access
to
valuable
(Z)-β-amidovinyl
sulfones
at
mild
conditions.
Moreover,
synthetic
application
this
was
demonstrated
by
late-stage
functionalization
numerous
bioactive
molecules.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 22, 2025
A
mild
and
atom-economical
reaction
for
the
Sc(OTf)3-catalyzed
1,3-hydroxyheteroarylation
of
bicyclo[1.1.0]butanes
(BCBs)
with
azaaryl
N-oxides
via
an
unprecedented
[4π+2σ]
cycloaddition/ring-opening
process
is
described.
This
transformation
provides
a
novel
strategy
highly
regio-
diastereoselective
preparation
azaheterocycle-tethered
1,1,3,3-tetrasubstituted
cyclobutane
derivatives
offers
broad
substrate
scope
high
yields.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(56), P. 7228 - 7231
Published: Jan. 1, 2024
A
visible-light-induced
K
2
S
O
8
-promoted
cascade
sulfonation/cyclization
reaction
to
afford
a
series
of
sulfonated
quinolino[2,1-
b
]quinazolinones
has
been
developed
under
mild
conditions.
Synthesis,
Journal Year:
2023,
Volume and Issue:
55(18), P. 2799 - 2816
Published: May 19, 2023
Abstract
Sulfur-containing
compounds
are
very
common
and
important
heteroatom
skeletons
widely
found
in
natural
products,
pharmaceuticals
bioactive
compounds.
Moreover,
the
development
of
synthetic
routes
to
organosulfur
has
attracted
considerable
attention
due
their
wide
range
applications
organic
chemistry,
pharmaceutical
industry
materials
science.
As
one
most
powerful,
green
eco-friendly
research
areas,
electrosynthesis,
contrast
conventional
synthesis,
can
avoid
use
harmful
stoichiometric
external
oxidants
or
reductants.
Importantly,
halide
salts
used
as
supporting
electrolytes
redox
catalysts
indirect
electrosynthesis
limitations
imposed
by
high
overpotentials
direct
electrosynthesis.
In
recent
years,
significant
progress
been
made
on
halogen-mediated
this
review,
scope,
mechanisms
electrochemical
transformations
sulfur-containing
presented
discussed.
1
Introduction
2
S–C
Bond
Formation
2.1
Organic
Thiocyanates
2.2
Sulfonyl
Compounds
2.3
Other
Sulfides
3
S–X
(X
=
N,
O,
S,
P)
Bonds
4
Conclusion
Outlook
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(43), P. 17962 - 17970
Published: Jan. 1, 2024
Herein,
we
report
the
first
visible-light-induced
strategy
for
rapid
synthesis
of
densely
functionalized
α-
and
γ-phosphorylated
β-sulfonyl
enamines
in
a
regio-
stereoselective
manner
from
N
-sulfonyl
allenamides
H-phosphine
oxides.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 4, 2024
Nitrogen
central
radicals
(NCRs)
are
versatile
synthetic
intermediates
for
creating
functional
nitrogen-containing
molecules.
Herein,
a
photosensitized
β-sulfonylamination
of
terminal
alkynes
as
well
acetylene
has
been
established
by
employing
N-sulfonyl
heteroaromatics
bifunctional
reagents
(BFRs)
to
efficiently
deliver
(E)-β-sulfonylvinylamines
with
excellent
regio-
and
stereoselectivities.
Mechanistic
studies
suggest
base-accelerated
energy
transfer
(EnT)
photocatalysis
involving
aromatic
NCR
formation,
radical
addition
alkynes,
sulfonylation
processes.
Organic & Biomolecular Chemistry,
Journal Year:
2023,
Volume and Issue:
21(42), P. 8488 - 8493
Published: Jan. 1, 2023
The
paper
details
an
electrochemical
method
that
couples
olefins
with
benzotriazoles
to
form
C(sp2)-N
bonds,
enabling
the
synthesis
of
N-vinyl
in
moderate
good
yields.
nBu4NI
functions
as
both
electrolyte
and
iodine
mediator,
does
not
require
oxidants
or
metals.
It
is
a
highly
atom-economical
clean
reaction,
hydrogen
sole
byproduct.
