Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(51), P. 9213 - 9218
Published: Dec. 15, 2023
Herein
we
employed
ethynylethylene
carbonates
(EECs)
to
achieve
formal
[4
+
1]
and
[3
3]
cycloaddition
with
cyclic
1,3-dicarbonyl
compounds.
On
one
hand,
EECs
styryl
substitution
could
undergo
a
remotely
controlled
enantioselective
reaction.
This
reaction
exhibits
good
chemoselectivity,
regioselectivity,
enantioselectivity.
In
addition,
of
compounds
was
also
achieved,
leading
series
4H-pyrans
impressive
chemoselectivity
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(23), P. 5016 - 5020
Published: June 3, 2024
Spirolactones
are
widely
found
in
pharmaceuticals
and
bioactive
natural
products.
However,
efficient
environmentally
friendly
approaches
to
accessing
spirolactones
still
highly
desirable.
Herein,
a
novel
electrochemical
synthesis
of
from
α-tetralone
derivatives
with
methanol
as
C1
source
is
described.
This
reaction
exhibits
high
efficiency
good
functional
group
tolerance.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(32), P. 6793 - 6797
Published: Aug. 1, 2024
Herein
we
report
a
strategy
for
the
enantioselective
synthesis
of
spirocycles
containing
all-carbon
quaternary
centers
via
nickel-catalyzed
intramolecular
addition
lactone
enolates
to
aryl
nitriles.
The
established
α-spirocyclization
efficiently
and
enantioselectively
forges
5-,
6-,
7-membered
rings,
performing
best
in
rings
(up
90%
ee).
This
discovery
represents
an
expansion
synthetic
toolkit
spirocyclization,
providing
access
chiral,
pharmaceutically
relevant
spirocyclic
products.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(8), P. 1671 - 1675
Published: Jan. 1, 2024
The
development
of
efficient
and
straightforward
strategies
for
obtaining
chiral
complex
molecules
from
readily
available
starting
materials
is
great
value
in
drug
discovery.
stereodivergent
synthesis
heterocycles
bearing
quaternary
centers
remains
a
challenge
due
to
inherent
steric
issues.
Herein,
we
report
an
enantioselective
copper-catalyzed
decarboxylative
[3
+
2]
cycloaddition
propargyl
cyclic
carbonates/carbamates
with
4-hydroxycoumarins
afford
wide
range
dihydrofuro[3,2-
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 25, 2024
An
electrochemical
reductive
bimolecular
cycloaddition
of
2-arylideneindane-1,3-diones
has
been
reported
for
the
synthesis
spirocyclopentanole
indane-1,3-diones
bearing
five
contiguous
stereocenters
with
vicinal
tetrasubstituted
stereocenters,
especially
involving
a
quaternary
carbon
center,
in
moderate
to
good
yields
and
excellent
diastereoselectivities.
The
present
protocol
features
mild
reaction
conditions,
no
external
chemical
redox
reagents,
atom
economy,
gram-scale
synthesis.
In
addition,
mechanistic
investigation
indicates
that
reactions
proceed
through
radical
pathway.
