European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(47)
Published: Sept. 13, 2024
Abstract
A
well‐ordered
strategy
of
sulfoxonium
ylides
as
a
directing
group
well
carbene
source
for
the
Ru‐catalysed
[4+2]
and
Rh‐catalysed
[4+1]
carbo‐annulations
with
maleimides
has
been
described.
These
novel
methodologies
have
successfully
established
synthesis
complex
spiroindanones
benzoisoindoles
containing
compounds
by
transition
metal‐mediated
C−H
activation/functionalization
reactions.
Further,
annulated
were
obtained
in
absence
any
oxidant.
possible
rationale
remarkable
divergent
selectivity
between
two
catalysts
proposed.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 4, 2024
Transition-metal-catalyzed
C-H
activation
has
proven
to
be
a
powerful
tool
for
the
late-stage
modification
of
peptides.
We
herein
report
method
site-selective
alkylation
peptides
with
maleimides
through
Pd-catalyzed
β-C(sp
Asian Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
12(10)
Published: Aug. 23, 2023
Abstract
The
[Ru(
p
‐cymene)Cl
2
]
‐catalyzed
reaction
of
2‐arylpyridines
with
1‐aryl‐2‐vinylpyrrolidines
is
carried
out
in
CF
3
CH
OH
at
40
°C
the
presence
KOAc,
affording
ortho
‐C−H
allylation
products
arenes
29
%
to
99
yields
and
1:0.7
1
:
5.4
Z
/
E
ratio.
amino
groups
remain
product
molecules.
protocol
suits
for
a
wide
scope
substrates
tolerates
functional
including
alkyl,
aryl,
MeO,
F,
Cl,
Br,
OCF
,
groups.
Authorea (Authorea),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 8, 2024
An
efficient
copper-catalyzed
annulation
of
enaminones
with
maleimides
has
been
developed.
This
reaction
provides
a
practical
approach
towards
the
synthesis
various
pyrrolo[3,4-e]isoindoles
in
moderate
to
good
yields.
Notable
features
method
include
use
2-aminopyridine
group
as
traceless
directing
group,
wide
scope
substrates
functional
compatibility
and
applicability
gram
scale.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(47)
Published: Sept. 13, 2024
Abstract
A
well‐ordered
strategy
of
sulfoxonium
ylides
as
a
directing
group
well
carbene
source
for
the
Ru‐catalysed
[4+2]
and
Rh‐catalysed
[4+1]
carbo‐annulations
with
maleimides
has
been
described.
These
novel
methodologies
have
successfully
established
synthesis
complex
spiroindanones
benzoisoindoles
containing
compounds
by
transition
metal‐mediated
C−H
activation/functionalization
reactions.
Further,
annulated
were
obtained
in
absence
any
oxidant.
possible
rationale
remarkable
divergent
selectivity
between
two
catalysts
proposed.
