Synthesis,
Journal Year:
2023,
Volume and Issue:
56(01), P. 47 - 54
Published: Nov. 23, 2023
Abstract
A
phosphonium-assisted
C–H
cyclization
with
iodonium
ylides
has
been
developed
under
redox-neutral
rhodium(III)
catalysis,
offering
a
wide
variety
of
valuable
isocoumarins
in
moderate
to
good
yields.
This
transformation
proceeds
through
activation,
carbene
insertion,
and
nucleophilic
addition
processes.
The
reaction
occurs
low
catalyst
loading
short
time
does
not
require
an
oxidant.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(24), P. 5136 - 5140
Published: June 7, 2024
Herein,
we
report
a
rhodium-catalyzed
C–H
activation/[4+2]
cyclization
reaction
between
α,β-unsaturated
amides
and
iodonium
ylides
for
the
synthesis
of
novel
7,8-dihydroquinoline-2,5-diones
analogues.
This
protocol
provides
series
pyridones
fused
with
saturated
cycles
good
functional
group
compatibility,
water
air
tolerance,
to
excellent
yields
under
mild
green
conditions.
Additionally,
scale-up
can
be
smoothly
performed
as
low
0.25
mol
%
catalyst
loading.
Recycling
experiments
different
transformation
were
also
carried
out
demonstrate
potential
synthetic
utility
this
protocol.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(8), P. 1744 - 1750
Published: Feb. 22, 2024
Abstract
The
transmetalation
triggered
rhodium‐catalyzed
C−H
bond
activation
and
tandem
annulation
of
2‐biphenylboronic
acids
with
sulfoxonium
ylides
or
iodonium
has
been
developed.
Various
products
phenanthrenes
were
constructed
under
redox‐neutral
conditions
in
34–86%
yields.
Several
mechanism
exploration
experiments
derivatization
reactions
conducted
sequence
to
gain
a
deeper
understanding
the
process
potential
this
transformation.
It
offers
an
alternative
approach
for
synthesis
phenanthrene
derivatives.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 27, 2025
By
means
of
simple
Rh
catalysis,
the
direct
activation
ortho-C-H
bond
in
aryl
enaminones
has
been
realized
with
enaminone
structure
as
a
traceless
directing
fragment.
The
products
resulting
from
C-H
alkenylation
and
further
annulation
via
intramolecular
addition
could
be
accessed
depending
upon
alkenes.
annulated
used
for
easy
synthesis
valuable
2-aza-fluorenones
one-pot
operation
by
employing
NH4OAc.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(17), P. 1986 - 1992
Published: April 25, 2024
Comprehensive
Summary
The
rhodium‐catalyzed
C—H
bond
activation
and
cyclization
of
3‐oxopent‐4‐enenitriles
with
alkynes
proceed
efficiently.
Various
2
H
‐pyrans
multiple
substituents
are
achieved
in
good
yields
through
regioselective
formation
C—O
C—C
bonds.
Transformations
involving
hydroxy‐alkynoates
resulted
products
a
furo[3,4‐
b
]pyran
skeleton
via
further
intramolecular
ester
exchange
processes.
Different
from
the
traditional
“1‐oxatrienes
pathway”,
this
method
for
synthesis
useful
possesses
certain
highlights
terms
readily
available
substrates,
stable
easily
derivatized
products,
gentle
convenient
operation
process,
step
atom
economy.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(15), P. 3567 - 3567
Published: July 29, 2024
Transition-metal-catalyzed
directed
C-H
functionalization
with
various
carbene
precursors
has
been
widely
employed
for
constructing
a
wide
range
of
complex
and
diverse
active
molecules
through
metal
migratory
insertion
processes.
Among
precursors,
iodonium
ylides
serve
as
novel
emerging
precursor
features
including
easy
accessibility,
thermal
stability
high
activity,
which
have
attracted
great
attention
from
organic
chemists
achieved
tremendous
success
in
transformation.
In
this
review,
recent
progress
on
the
application
multifunctional
coupling
characteristics
bond
activation
reactions
is
summarized,
potential
discussed.
Organometallics,
Journal Year:
2023,
Volume and Issue:
42(16), P. 2228 - 2237
Published: Aug. 7, 2023
An
efficient
iridium-catalyzed
C–H
activation/annulation
reaction
utilizing
pyridotriazole
as
the
traceless
bifunctional
directing
group
and
carbene
precursor
to
form
1H-isochromenes
was
described.
This
proceeded
smoothly
under
an
additive-free
condition
at
room
temperature,
which
is
compatible
with
a
wide
range
of
functional
groups
in
high
yields.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(22), P. 15597 - 15607
Published: Nov. 2, 2023
Amide
and
lactam
frameworks
were
synthesized
via
an
efficient
two-step
strategy.
In
this
protocol,
pyridotriazoles
first
treated
with
isocyanates
to
form
the
corresponding
amides,
which
found
be
sufficiently
reactive
undergo
subsequent
intramolecular
N-H
insertion
in
absence
of
any
additional
reagents
or
catalysts.
