Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 27, 2025
Comprehensive
Summary
Presented
herein
is
a
condition‐controlled
selective
synthesis
of
CF
3
‐chromene
and
‐benzofuran
based
on
the
reaction
N
‐phenoxyacetamide
‐ynone.
When
carried
out
in
MeOH
under
catalysis
Rh(III),
formed
via
C—H
metalation‐initiated
alkenylation,
acetamide
group
migration
intramolecular
oxo
‐nucleophilic
addition.
On
other
hand,
when
run
DMSO
promotion
CsOAc,
generated
aza
‐Michael
addition‐initiated
[3,3]‐σ
rearrangement,
addition
water
elimination.
To
our
knowledge,
this
first
report
construction
chromene
or
benzofuran
scaffold
along
with
introduction
unit
from
same
starting
materials.
The
methodology
was
scalable
products
could
be
readily
transformed
into
valuable
products.
Moreover,
thus
obtained
possess
decent
anticancer
activity.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(11), P. 7214 - 7261
Published: May 16, 2024
In
recent
years,
visible
light-induced
reactions
of
diazo
compounds
have
attracted
increasing
attention
in
organic
synthesis,
leading
to
improvement
existing
reactions,
as
well
the
discovery
unprecedented
transformations.
Thus,
photochemical
or
photocatalytic
generation
both
carbenes
and
radicals
provide
milder
tools
toward
these
key
intermediates
for
many
valuable
However,
vast
majority
transformations
represent
new
reactivity
modes
compounds,
which
are
achieved
by
decomposition
photoredox
catalysis.
particular,
use
a
redox-active
photocatalysts
opens
avenue
plethora
radical
reactions.
The
application
methods
led
inaccessible
classical
associated
with
metal
carbenes.
most
cases,
act
sources
but
can
also
serve
acceptors.
Importantly,
described
processes
operate
under
mild,
practical
conditions.
This
Review
describes
this
subfield
compound
chemistry,
particularly
focusing
on
advancements.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(3), P. 1846 - 1857
Published: Jan. 12, 2024
Herein,
we
describe
an
efficient
transition-metal-free
regioselective
C3alkylation
of
indoles
for
the
synthesis
bis(indolyl)methanes
and
3-styryl
indoles.
Nitrobenzene
is
employed
as
oxidant
to
oxidize
alcohols
in
presence
a
strong
base
reaction
avoids
use
transition
metals
such
Ru
Mn.
The
protocol
provides
favorable
route
access
biologically
active
compounds
arundine,
vibrindole
A,
turbomycin
B.
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Comprehensive
Summary
An
atmospheric‐oxygen‐mediated
four‐component
reaction
was
developed
for
the
divergent
synthesis
of
pyrazolo[1,5‐
a
]pyrimidine
and
pyrazolo[3,4‐
b
]pyridine
derivatives
from
readily
available
alcohols
3‐aminopyrazoles.
In
this
transformation,
atmospheric
oxygen
serves
as
green
oxidant,
promoting
equivalent
aldehydes
four
types
N
‐containing
heterocycles
(>
40
examples).
Remarkably,
transformation
features
metal‐free
molecular
diversity.
Chinese Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
41(22), P. 2963 - 2968
Published: June 24, 2023
Comprehensive
Summary
A
photoelectrochemical
approach
for
the
C—H
silylation
of
heteroarenes
through
dehydrogenation
cross‐coupling
with
H
2
evolution
has
been
developed.
The
depends
on
hydrogen
atom
transfer
(HAT)
from
silanes
to
Cl‐radical
generated
light‐induced
homolytic
cleavage
Cl
,
in
which
was
produced
by
electrochemical
oxidation
chloride.
large
number
silylated
heterocyclic
molecules
are
rapidly
constructed
satisfactory
yields
without
relying
oxidants
and
metal
reagents.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2511 - 2516
Published: March 20, 2024
This
work
demonstrates
the
synthesis
of
a
variety
perfluoroalkyl
heterocycles
via
visible-light-driven
radical-polar
crossover
cyclization
strategy.
In
this
process,
single-electron
reduction/SNV-type/cyclization
sequences
follow
radical
addition
reaction
diazoester,
which
differs
from
current
role
diazoesters
as
precursors/acceptors.
transformation
excellent
functional
group
compatibility
and
allows
for
modification
many
bioactive
molecules
with
diazoesters.
Such
could
represent
novel
approach
to
photochemical
diazo
compounds.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(4), P. 2505 - 2515
Published: Feb. 5, 2024
A
novel
iodine-promoted
difunctionalization
of
α-C
sites
in
enaminones
was
demonstrated
as
a
means
synthesizing
variety
fully
substituted
thiazoles
by
constructing
C–C(CO),
C–S,
and
C–N
bonds.
This
transformation
allows
the
realization
unusual
aryl
C2
synthons
simultaneously
thioylation
dicarbonylation
sites.
preliminary
mechanistic
study
performed
indicated
that
cleavage
C═C
bonds
involves
bicyclization/ring-opening
oxidative
coupling
sequence.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(7), P. 1917 - 1923
Published: Jan. 1, 2024
We
present
a
novel
synthesis
of
CF
3
-
and
alkynyl-substituted
quinoline
derivatives
based
on
Rh(
iii
)-catalyzed
cascade
reactions
N
-aryl
amidines
with
two
-ynones.
Then,
some
products
are
transformed
into
polycyclic
-benzo[
k
]phenanthridines
through
an
intramolecular
annulation
reaction.
