Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(9)
Published: July 5, 2024
A
novel
Rh‐catalyzed
three‐component
synthesis
of
N
‐(
o
‐alkylaryl)
pyrazoles
via
cascade
pyrazole
annulation
and
aryl
C‐H
conjugate
addition
to
alkenes
has
been
developed
with
enaminones,
hydrazines,
functionalized
as
starting
materials.
The
raw
materials
used
in
this
reaction
are
simple,
cheap,
readily
available,
the
reactions
feature
excellent
step
economy
by
furnishing
products
formation
a
ring
key
activation
one‐step
operation.
Moreover,
proceeds
smoothly
under
air
atmosphere,
making
it
easy
operate.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 13, 2024
Hypervalent
iodine(III)
compounds
have
found
wide
application
in
modern
organic
chemistry
as
environmentally
friendly
reagents
and
catalysts.
iodine
are
commonly
used
synthetically
important
halogenations,
oxidations,
aminations,
heterocyclizations,
various
oxidative
functionalizations
of
substrates.
Iodonium
salts
arylating
reagents,
while
iodonium
ylides
imides
excellent
carbene
nitrene
precursors.
Various
derivatives
benziodoxoles,
such
azidobenziodoxoles,
trifluoromethylbenziodoxoles,
alkynylbenziodoxoles,
alkenylbenziodoxoles
group
transfer
the
presence
transition
metal
catalysts,
under
metal-free
conditions,
or
using
photocatalysts
photoirradiation
conditions.
Development
hypervalent
catalytic
systems
discovery
highly
enantioselective
reactions
chiral
represent
a
particularly
recent
achievement
field
chemistry.
Chemical
transformations
promoted
by
many
cases
unique
cannot
be
performed
any
other
common,
non-iodine-based
reagent.
This
review
covers
literature
published
mainly
last
7-8
years,
between
2016
2024.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2363 - 2369
Published: March 16, 2024
Abstract
A
synthetic
protocol
was
developed
to
synthesize
highly
functionalized
3‐furylmethyl
chromones
from
enynones
and
o
‐hydroxyphenyl
enaminones
via
silver‐catalyzed
cascade
bis‐heteroannulation
reaction.
This
strategy
features
broad
substrate
scope
good
functional
group
tolerance.
Furthermore,
the
chromone
skeleton
shows
potential
application
value
through
further
gram‐scale
synthesis
derivatization.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3906 - 3912
Published: Jan. 1, 2024
A
chemodivergent
and
skeleton-controllable
annulation
reactions
of
readily
available
o
-HPEs
aryldiazonium
salts
was
described
for
the
synthesis
highly
functionalized
pyridazine-fused
chromones
with
high
antiviral
activity
higher
safety.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(23), P. 4980 - 4985
Published: June 4, 2024
An
unprecedented
selective
chromone
annulation
reaction
controlled
by
solvent
for
the
divergent
synthesis
of
two
types
2,3-disubstituted
skeletons
has
been
developed.
A
variety
2-chromonyl-3-hydrazono-chromones
and
2-alkoxy-3-hydrazono-chromones
were
constructed
efficiently
from
readily
available
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(24), P. 5136 - 5140
Published: June 7, 2024
Herein,
we
report
a
rhodium-catalyzed
C–H
activation/[4+2]
cyclization
reaction
between
α,β-unsaturated
amides
and
iodonium
ylides
for
the
synthesis
of
novel
7,8-dihydroquinoline-2,5-diones
analogues.
This
protocol
provides
series
pyridones
fused
with
saturated
cycles
good
functional
group
compatibility,
water
air
tolerance,
to
excellent
yields
under
mild
green
conditions.
Additionally,
scale-up
can
be
smoothly
performed
as
low
0.25
mol
%
catalyst
loading.
Recycling
experiments
different
transformation
were
also
carried
out
demonstrate
potential
synthetic
utility
this
protocol.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
26(1), P. 46 - 50
Published: Dec. 27, 2023
By
employing
enaminones
and
thiuram
disulfides
as
starting
materials,
the
frontiers
of
Newman–Kwart
rearrangement
have
been
expanded
to
alkenyl
system
for
first
time.
In
addition,
instead
leading
formation
simple
carbamothioates,
has
led
unprecedented
construction
S-heteroaryls.
Depending
on
differences
in
enaminone
structure,
efficient
synthesis
functionalized
isothiazoles
thiophenes
achieved.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(35), P. 7425 - 7430
Published: Aug. 22, 2024
Presented
herein
is
an
atom-
and
step-economical
method
enabling
the
precise
assembly
of
a
heptacyclic
scaffold
containing
both
azocine
indoline
units
through
cascade
reactions
indolin-1-yl(aryl)methanimines
with
diazo
indanediones.
The
formation
products
involves
C–H
bond
activation
double
carbene
insertion
followed
by
intramolecular
condensation,
retro-[2
+
2]
cycloaddition,
recyclization.
This
reaction
not
only
provided
concise
straightforward
strategy
for
synthesis
otherwise
difficult
to
obtain
compounds
from
readily
available
substrates
but
also
disclosed
unprecedented
mode
derivatives
compounds.
In
general,
this
novel
synthetic
protocol
has
advantages,
such
as
easily
obtainable
substrates,
structurally
sophisticated
products,
procedure,
good
compatibility
diverse
functional
groups,
ready
scalability.
Moreover,
thus
obtained
showed
decent
antiproliferative
activity
against
three
human
cancer
cell
lines.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(15), P. 11060 - 11066
Published: July 24, 2024
Reported
herein
is
a
new
photocatalytic
annulation
for
the
synthesis
of
2,3,4,6-tetrasubstituted
pyridines
with
enaminones
and
N,N,N′,N′-tetramethyl
ethylenediamine
(TMEDA).
The
reactions
take
place
without
requiring
transition
metal
reagent
provide
products
broad
scope.
methyl
in
TMEDA
acts
as
carbon
source
pyridine
ring
construction,
BrCF2CO2Et
plays
role
terminal
oxidant
free
radical
quenching.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(12), P. 8521 - 8530
Published: June 3, 2024
An
oxidative
free-radical
C(sp2)–H
bond
chlorination
strategy
of
enaminones
has
been
developed
by
using
LiCl
as
a
chlorinating
reagent
and
K2S2O8
an
oxidant.
This
transformation
provides
new
straightforward
synthetic
methodology
to
afford
highly
functionalized
α-chlorinated
with
Z-configuration
in
good
excellent
yields.
