Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(14), P. 8657 - 8739
Published: July 2, 2024
Chiral
phosphorus
ligands
play
a
crucial
role
in
asymmetric
catalysis
for
the
efficient
synthesis
of
useful
optically
active
compounds.
They
are
largely
categorized
into
two
classes:
backbone
chirality
and
P-stereogenic
ligands.
Most
reported
belong
to
former
class.
Privileged
ones
such
as
BINAP
DuPhos
frequently
employed
wide
range
catalytic
transformations.
In
contrast,
latter
class
has
remained
small
family
many
years
mainly
because
their
synthetic
difficulty.
The
late
1990s
saw
emergence
novel
with
superior
enantioinduction
ability
Rh-catalyzed
hydrogenation
reactions.
Since
then,
numerous
have
been
synthesized
used
This
Review
summarizes
thus
far,
including
stereochemical
electronic
properties
that
afford
high
excellent
enantioselectivities.
Examples
reactions
use
this
described
together
applications
construction
key
intermediates
natural
products
therapeutic
agents.
literature
covered
dates
back
1968
up
until
December
2023,
centering
on
studies
published
later
years.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(22), P. 11165 - 11206
Published: Jan. 1, 2024
This
review
explores
the
fascinating
world
of
molecules
featuring
multiple
stereogenic
elements,
unraveling
different
strategies
designed
over
years
for
their
enantioselective
synthesis.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(28)
Published: May 16, 2024
Abstract
Axially
chiral
biaryl
scaffolds
are
important
in
pharmaceuticals,
natural
products,
and
asymmetric
synthesis.
Atroposelective
ring‐opening
of
configurationally
labile
reagents
via
dynamic
kinetic
transformation
provides
a
valuable
approach
to
access
axially
atropisomers.
This
review
summarizes
seminal
contributions
recent
advancements
on
this
topic
based
the
use
different
types
reagents.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(23), P. 6819 - 6849
Published: Jan. 1, 2024
This
review
highlights
recent
advances
in
the
atroposelective
preparation
of
axially
chiral
azole
derivatives,
emphasizing
mechanistic
insights
and
synthetic
applications
development
this
class
five-membered
heterocyclic
frameworks.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(16), P. 3453 - 3457
Published: April 11, 2024
1,2-Bis(diphenylphosphino)ethanes
(DPPEs)
are
versatile
and
immensely
important
ligands
in
transition
metal
catalysts.
Here
we
report
the
dithiophosphinylation
of
readily
available
allenyl
acetates
to
give
DPPEs
high
yields
regioselectivity.
This
protocol
features
a
broad
substrate
scope
mild
conditions,
avoiding
use
metals
air-sensitive
sources
phosphorus.
Mechanism
studies
indicate
that
reaction
was
accomplished
via
an
SN2′-type
addition–elimination
followed
by
1,4-addition
step.
Chemistry - An Asian Journal,
Journal Year:
2024,
Volume and Issue:
19(22)
Published: July 16, 2024
Abstract
Over
the
decades,
functionalized
heteroaromatic
compounds
and
their
scaffolds
have
drawn
significant
attention
in
synthetic
organic
chemistry
as
well
interdisciplinary
sciences
due
to
prevalence
natural
products,
hormones,
vitamins,
applications
pharmaceuticals,
agrochemicals,
veterinary
dyes
pigments,
bio‐imaging,
semiconductors,
optoelectronics,
etc.
This
review
explores
various
strategies
for
functionalization
of
numerous
5,6
benzo‐fused
derivatives
such
indole,
benzofuran,
benzothiophene,
benzimidazole,
benzoxazole,
benzothiazole
benzotriazole
through
methods
including
C−H
activation,
cross‐coupling,
metal
catalysis,
photo‐catalysis,
electrocatalysis
organocatalysis
recent
years
(2019–2023).
Highly
heterocyclic
are
important
precursors
synthesizing
many
bioactive
drugs
like
fenbendazole,
viozan,
griseofulvin,
zileuton,
flunoxaprofen,
optoelectronic
materials,