Abstract
Herein,
we
report
a
multidimensional
screening
strategy
to
discover
Electron
Donor‐Acceptor
(EDA)
complex
photochemical
reactions
using
only
simple
photographic
devices,
such
as
webcams
or
cellphones,
combined
with
TLC
analysis.
An
algorithm
was
designed
automatically
identify
EDA‐complex
reactive
mixtures
in
solution
by
processing
digital
images
from
96‐well
microplate,
alongside
results.
The
code
detects
the
absorption
region
of
mixture
visible
spectrum
and
quantifies
color
changes
through
grayscale
values.
Integrated
automatic
analysis
further
classifies
colorimetric
reactions,
non‐reactive,
potentially
EDA
complexes.
Leveraging
this
platform,
have
developed
new
EDA‐mediated
approach
synthesize
iminophosphoranes
yields
up
90%.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(12), P. 2440 - 2444
Published: March 19, 2024
An
iodoarene-driven
electroreductive
remote
C(sp3)–H
arylation
of
unsymmetrical
1-(o-iodoaryl)alkyl
ethers
with
cyanoarenes
for
the
site
selective
synthesis
α-(hetero)aryl
is
developed.
With
introduction
as
both
aryl
sources
and
electron
transfer
mediators,
this
method
includes
an
strategy
to
enable
regiocontrollable
formation
two
new
bonds,
one
C(sp2)–H
bond,
C(sp2)–C(sp3)
in
a
single
reaction
step
through
sequence
halogen
atom
(XAT),
hydrogen
(HAT),
radical–radical
coupling,
decyanation.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(10), P. 2186 - 2208
Published: April 4, 2024
Abstract
This
review
presents
an
outline
of
current
advancements
in
the
photochemical
and
electrochemical
synthesis
oxazoles
isoxazoles.
Oxazole
isoxazole
are
important
building
blocks
for
a
variety
medicinally
useful
compounds.
Therefore,
these
heterocycles
via
sustainable
technologies
is
worth
demanding.
Photochemical
two
among
few
technologies.
covers
brief
discussion
on
reaction
parameters
like
catalysts,
substrates
scope,
temperature,
solvents,
electrodes,
electrolytes
(in
case
process),
light
source
process)
individual
reaction.
Detailed
mechanistic
insight
each
also
presented.
Finally,
summary,
future
direction
toward
development
effective
methods
isoxazoles
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(3), P. 1473 - 1482
Published: Jan. 16, 2024
A
convenient
and
new
synthetic
approach
has
been
developed
for
the
oxidative
cross-coupling
of
C–N
bond
through
reaction
between
arylglyoxylic
acids
tetraalkylthiuram
disulfides.
The
proceeds
under
ambient
air
at
room
temperature
in
presence
visible
light.
This
offers
a
metal-,
base-,
photocatalyst-,
solvent-free
synthesis
various
α-ketoamides
with
moderate
to
excellent
yields
via
radical
pathway.
In
addition,
this
protocol
demonstrates
potential
application
gram-scale
synthesis.
ACS Catalysis,
Journal Year:
2024,
Volume and Issue:
14(17), P. 13451 - 13496
Published: Aug. 26, 2024
Alcohols
are
abundant
with
versatile
structural
variety
and
have
ample
use
as
pivotal
functional
groups
in
numerous
organic
processes.
Because
of
their
frequent
occurrence
enumerable
natural
products,
bioactive
molecules,
medicinal
components,
alcohol
functionalities
provide
a
promising
scope
research
to
advance
the
operational
diversity
for
improving
clinical
success.
Recent
years
witnessed
design
modern
C–C
C–heteroatom
bond-forming
approaches
easily
accessible
commercially
available
unactivated
aliphatic
alcohols
native
adaptive
sp3
handles,
hence
offering
groundbreaking
transformative
pathways
functionalization
complex
molecular
architectures.
The
judicial
application
appropriate
activating
generate
alkyl
radical
from
through
C–O
bond
fragmentation
employ
it
potential
alkylating
agent
unfolds
unique
synthetic
strategies,
thereby
replacing
obvious
requirement
halides.
This
review
elaborately
discusses
recent
trends
regarding
using
C(sp3)-centered
various
chemical
transformations
by
exploiting
different
activation
modes
disrupter
under
photoredox
catalysis.
presentation
is
organized
nature
scaffolds,
kind
formation,
progress
achieved
this
domain
since
original
discovery
providing
illustrative
examples
mechanistic
details,
focus
on
difficulties
future
prospects.
Abstract
A
visible‐light‐promoted
strategy
for
the
decarboxylative
C‐3
carbamoylation
of
quinoxalinone
scaffolds
is
developed.
This
approach
initiates
through
formation
an
EDA
complex
between
oxamic
acid
and
quinoxalinone.
Successive
SET
construct
C−C
bond.
method
utilizes
aerial
oxygen
as
green
oxidant
eradicates
process
from
use
external
photocatalysts
transition
metals.
Detailed
synthetic
photophysical
studies
enlighten
reaction
pathway.
Advanced Synthesis & Catalysis,
Journal Year:
2024,
Volume and Issue:
366(14), P. 3138 - 3143
Published: May 11, 2024
Abstract
Visible‐light‐induced
difunctionalization
of
alkenes
is
a
powerful
strategy
for
constructing
complex
molecules.
Herein,
we
disclose
three‐component
1,2‐alkylpyridylation
under
mild
and
photosensitizers‐free
conditions.
UV‐vis
absorption
spectroscopy
studies
NMR
titration
experiments
indicate
that
the
formation
an
EDA
between
4‐alkyl‐DHPs
4‐cyanopyridines.
Primary,
secondary,
tertiary
C(
sp
3
)‐centered
radicals
were
formed
by
homolytic
cleavage
4‐alkyl‐DHPs.
Gram‐scale
synthesis
late‐stage
functionalization
medicinally
relevant
molecules
showed
synthetic
potential
our
methodology.
Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
30(44)
Published: May 24, 2024
A
magnetically
isolable
iron
oxide
nanoparticles
is
introduced
as
an
efficient
heterogeneous
photocatalyst
for
non-directed
C-H
arylation
employing
aryl
diazonium
salts
the
precursors.
This
first-row
transition
metal-based
revealed
versatile
activities
and
applicable
to
a
wide
range
of
substrates,
demonstrating
brilliant
efficacy
superior
recyclability.
Detailed
catalytic
characterization
describes
physical
properties
redox
behavior
Fe-catalyst.
Adequate
control
experiments
helped
establish
radical-based
mechanism
arylation.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(16), P. 2232 - 2235
Published: Jan. 1, 2024
Herein,
we
report
a
metal-free
protocol
for
oxidative
carbotrifluoromethylation
of
maleimides
with
imidazopyridines
and
Langlois’
reagent
using
PIDA
as
an
oxidant.
ChemSusChem,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 8, 2024
C-H
Functionalization
of
heteroarenes
stands
as
a
potent
instrument
in
organic
synthesis,
and
with
the
incorporation
visible
light,
it
emerged
transformative
game-changer.
In
this
domain,
electron
donor-acceptor
(EDA)
complex,
formed
through
pairing
an
electron-rich
substrate
electron-accepting
molecule,
has
garnered
substantial
consideration
recent
years
due
to
related
avoidance
requirement
photocatalyst
well
oxidant.
EDA
complexes
can
undergo
photoactivation
under
mild
conditions
exhibit
high
functional
group
tolerance,
making
them
potentially
suitable
for
functionalization
biologically
relevant
heteroarenes.
This
review
article
provides
overview
advancements
field
via
complex
literature
coverage
up
April,
2024.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(27), P. 5805 - 5810
Published: July 1, 2024
Minisci-type
dehydrogenative
coupling
of
C(sp3)–H
and
N-heteroaromatics
was
performed
with
N-hydroxysuccinimide
as
a
hydrogen
atom
transfer
catalyst
in
photoelectrochemical
cell
composed
mesoporous
BiVO4
photoanode
Pt
electrode.
In
the
absence
metal
catalysts
chemical
oxidants,
range
N-heteroarenes
(e.g.,
quinolines,
isoquinolines,
quinoxaline)
can
undergo
various
partners
to
form
corresponding
products
excellent
yields.
