Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
We
developed
a
Ru(II)-catalyzed
redox-neutral
C–H
olefination
of
N-methoxybenzamides
with
vinyl
sulfones.
The
reaction
is
operationally
simple
and
conducted
at
ambient
temperature
does
not
require
silver
additives
or
external
oxidants,
making
it
suitable
for
late-stage
functionalization.
Notably,
we
leveraged
the
leaving
group
ability
sulfinate
anion
to
synthesize
3-methyleneisoindolin-1-ones
through
tandem
olefination/cyclization/elimination
sequence
temperature.
Moreover,
successfully
demonstrated
synthetic
versatility
3-methyleneisoindolin-1-one
construction
an
isoindolobenzazepine
core.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(26), P. 3571 - 3574
Published: Jan. 1, 2024
Herein,
a
novel
Pd-catalyzed
denitrogenation/vinylation
of
benzotriazinones
using
vinylene
carbonate
as
the
vinylation
reagent
is
reported.
This
transformation
demonstrates
an
unprecedented
skeletal
editing
approach,
effectively
converting
NN
to
CC
fragments
Chinese Journal of Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 25, 2025
Comprehensive
Summary
Aminocarbonylative
heteroannulation
of
unsaturated
hydrocarbons
with
amines
and
CO
has
become
a
key
transformation
in
organic
synthesis
to
build
N
‐heterocycles.
In
this
report,
new
palladium‐catalyzed
aminocarbonylative
[3+2+1]/[4+2]
allylamines
4‐en‐1‐yn‐3‐yl
acetates
for
the
1,7,8,8a‐tetrahydroisoquinolin‐3(2
H
)‐ones
been
developed.
The
method
enables
construction
two
six‐membered
rings
single
reaction
step
leading
formation
isoquinolinone
scaffolds,
featuring
excellent
selectivity,
good
functional
group
compatibility
broad
substrate
scope.
A
possible
mechanism
involving
Pd‐catalyzed
isomerization
form
allenyl‐Pd
intermediate,
aminocarbonylation
cycloaddition
was
proposed.
Chemical Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Herein,
we
report
the
first
Cp*Co(
iii
)-catalyzed
redox-neutral
[4
+
2]
C–H
annulation
employing
sulfilimine
as
an
oxidizing
directing
group,
wherein
N–S
bond
serves
internal
oxidant.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(21), P. 16043 - 16048
Published: Oct. 15, 2024
The
dihydroisoquinolones
skeleton
is
ubiquitous
in
natural
products
and
biological
molecules.
Reported
strategies
for
constructing
usually
require
noble
metal
catalysts
or
stoichiometric
oxidants,
which
limit
their
wide
applications.
Herein,
we
developed
a
photoredox
catalyzed
tandem
denitrogenative
[4
+
2]
annulation
reaction
of
1,2,3-benzotriazin-4(3H)-ones
with
terminal
olefins.
A
variety
can
be
accessed
moderate
to
excellent
yield.
This
protocol
features
high
atom-economy,
mild
conditions,
external
oxidant-free,
enabling
the
synthesis
various
substituted
dihydroisoquinolones.
Organic Process Research & Development,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 7, 2024
As
the
field
of
nonprecious
metal
catalysis
continues
to
expand,
we
pursue
a
review
series
covering
selected
transformations
in
this
area
over
short
time
interval
highlight
practical
advancements.
We
seek
raise
awareness
both
current
art
and
need
continue
development
toward
broader
applications
earth-abundant
metals
chemical
pharmaceutical
industries.
