Photocatalytic fluoroalkylation by ligand-to-metal charge transfer DOI Creative Commons
Jingyi Liu,

Zhenwei Cui,

Jingjing Bi

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 6, 2024

Trifluoromethyl (CF

Language: Английский

Rational Molecular Editing: A New Paradigm in Drug Discovery DOI Creative Commons
Chunhua Ma, Craig W. Lindsley, Junbiao Chang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(14), P. 11459 - 11466

Published: June 21, 2024

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVEditorialNEXTRational Molecular Editing: A New Paradigm in Drug DiscoveryChunhua MaChunhua MaState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA for Research and Evaluation Innovative Drug, School Chemistry Chemical Engineering, Henan Normal University, Xinxiang, 453007, ChinaMore by Chunhua Mahttps://orcid.org/0000-0001-7613-6471, Craig W. Lindsley*Craig LindsleyVanderbilt University Medical Center, Franklin, Tennessee 37027, United States*E-mail: [email protected]More Lindsleyhttps://orcid.org/0000-0003-0168-1445, Junbiao Chang*Junbiao ChangCollege Chemistry, State Zhengzhou 450001, China*E-mail: Chang, Bin Yu*Bin YuCollege Yuhttps://orcid.org/0000-0002-7207-643XCite this: J. Med. Chem. 2024, XXXX, XXX, XXX-XXXPublication Date (Web):June 21, 2024Publication History Received13 June 2024Published online21 2024https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01347https://doi.org/10.1021/acs.jmedchem.4c01347editorialACS PublicationsPublished 2024 American Society. This publication is available under these Terms Use. Request reuse permissions free to access through this site. Learn MoreArticle Views-Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail (2 MB) Get e-AlertscloseSUBJECTS:Drug discovery,Macrocyclization,Molecules,Pharmaceuticals,Scaffolds e-Alerts

Language: Английский

Citations

24
Decatungstate-photocatalyzed direct acylation of N-heterocycles with aldehydes DOI
Zhiyang Zhang,

Fukun Cheng,

Xinyu Ma

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(12), P. 7331 - 7336

Published: Jan. 1, 2024

A novel photocatalytic acylation strategy was developed harnessing tetrabutylammonium decatungstate (TBADT) as a hydrogen atom transfer (HAT) photocatalyst to facilitate the direct coupling of aldehydes with N-heterocycles at ambient temperature.

Language: Английский

Citations

22
Phototriggered Self-Catalyzed Phosphorylation of 3,4-Dihydroquinoxalin-2(1H)-ones with Diarylphosphine Oxides in EtOH DOI
Yanfang Jiang, Wen‐Tao Ouyang,

Hong‐Tao Ji

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

A highly effective external photocatalyst- and additive-free method for the phosphorylation of 3,4-dihydroquinoxalin-2(1

Language: Английский

Citations

14
Direct C–H Alkylation of Benzothiadiazoles via Organic Photoredox Catalysis DOI

Guiqing Xu,

Jiayuan Lv,

Qingjie Ding

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(4), P. 2777 - 2781

Published: Feb. 5, 2024

2,1,3-Benzothiadiazole is widely used as a privileged scaffold in pharmaceuticals and organic functional materials. Nonetheless, many current methods for the functionalization of 2,1,3-benzothiadiazole rely on preactivation, transition metal catalysts/promoters, or an elevated reaction temperature. Herein we disclose transition-metal-free visible-light-induced photocatalytic method direct C–H alkylation using readily accessible carboxylic acid derivatives, i.e., N-hydroxyphthalimide esters (NHPEs), alkylating reagents under room This mild scalable highlighted by late-stage installation benzothiadiazole drugs natural products.

Language: Английский

Citations

8
N-Phenylphenothiazine-based Hyper-cross-linked Polymers for Recyclable, Heterogeneous Photocatalysis of Organic Transformations: A Strategy to Access 6-Difluoromethyl-phenanthridines DOI

Shengjie Song,

Wenjian Wang,

Yali He

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Herein, a N-phenylphenothiazine-based hyper-cross-linked polymer (PTH-HCP) was finely designed and constructed, which serves as metal-free heterogeneous photocatalyst for organic transformations. Characterization experiments have shown that this demonstrates outstanding stability, extensive surface area, exceptional photoelectric response properties. Moreover, PTH-HCP showed good catalytic efficiency recyclability in the photochemically driven difluoromethylation/cyclization reactions. This work provides strategy design construction of photocatalysts offers support their broad prospects synthetic applications.

Language: Английский

Citations

1
TEMPO/O2 Synergistically Mediated BiBrO‐Photocatalyzed Decarboxylative Phosphorylation of N‐Arylglycines DOI
Wen‐Tao Ouyang,

Hong‐Tao Ji,

Yuanyuan Liu

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(41)

Published: April 22, 2024

With both TEMPO and O

Language: Английский

Citations

5
Functionalization of 1,3‐Butadiene Derivatives under Photo/Electrocatalysis DOI

Yinghui Huang,

Linhui Shen,

Chunhua Ma

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(28)

Published: May 20, 2024

Abstract In recent years, the functionalization of 1,3‐butadiene has become an attractive strategy for constructing allyl compounds with molecular and structural complexity, current research focuses on synthetic chemistry organic synthesis. Compared traditional synthesis method, methods promoted by photochemistry or electrochemistry represent environmentally friendly mild strategy. this review, reactions under photochemical/electrochemical processes in years are reviewed according to classification systems, particular emphasis corresponding reaction mechanism, which lays a foundation further exploration new catalytic methods.

Language: Английский

Citations

5
Photomediated Hydro(deutero)acylation of Olefins by Decarboxylative Addition of α-Oxocarboxylic Acids DOI

Fan Gao,

Zhi-Yu Liao,

Yu-Hang Ye

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(4), P. 2741 - 2747

Published: Feb. 1, 2024

Acyl radicals have been generated from the decarboxylation of α-oxocarboxylic acids by using a readily accessible organic pyrimidopteridine photoredox catalyst under ultraviolet-A (UV-A) light irradiation. These reactive acyl were smoothly added to olefins such as styrenes and diverse Michael acceptors, with assistance H2O/D2O hydrogen donors, enabling easy access range ketones/β-deuterio ketones. A wide are compatible this reaction, which shows reliable, atom-economical, eco-friendly protocol. Furthermore, postsynthetic diversifications applications presented.

Language: Английский

Citations

4
Annulation Cascades of Cyclosulfonium Salts and Alkenes towards Sulfur‐Containing N‐Heterocycles by Visible Light/Copper Catalysis DOI
Jie Ma, Xufeng Li, Yuqing Chen

et al.

Chinese Journal of Chemistry, Journal Year: 2024, Volume and Issue: 42(14), P. 1637 - 1643

Published: April 3, 2024

Comprehensive Summary Although, great achievements have been made in the synthesis of heterocycles using radical addition/cyclization strategy, developing versatile alkyl precursors, especially non‐stabilized long chain radicals for this strategy still remains a huge challenge. Herein, we report an efficient annulation cascade reaction between cyclosulfonium salts and alkenes sulfur‐containing N ‐heterocycles by visible light/copper catalysis under mild conditions. The C—S bond cleavage/radical delivers variety corresponding containing aryl thioether motifs with good functional group tolerance. Significantly, current system could be used late‐stage functionalization complex bioactive molecules.

Language: Английский

Citations

4
Aerobic Oxidative Hydroxylation of Arylboronic Acids under Visible-Light Irradiation without Metal Catalysts or Additives DOI

Hongchen Lu,

Yameng Wan,

Qiongjin Wang

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(9), P. 1959 - 1964

Published: Feb. 26, 2024

Phenols are versatile synthetic intermediates and key structural motifs in many natural products biologically active compounds. We herein report a visible-light-induced aerobic oxidative hydroxylation of arylboronic acids/pinacol esters using air as oxidant without any catalysts base, etc., additives, providing green entry to variety phenols highly efficient concise fashion. This novel reaction is enabled by photoactivation an electron donor-acceptor complex, which THF serves both the solvent donor. DFT studies indicated that oxidation process involves concerted hydrogen abstraction transfer from dehydroxylation boronic acid undergoing spin crossover triplet singlet produce peroxoboronic intermidiate. Salient merits this chemistry include broad substrate scope excellent functional group tolerance, gram-scale synthesis, late-stage functionalizations well use air, visible light, catalyst- additive-free conditions. strategy introduces photoreaction mode with aid solvent, offering succinct environmentally sustainable route for synthesizing phenols. The strong practicability access modifying complex biorelevant molecules bode potential applications pharmaceutical chemistry.

Language: Английский

Citations

3