Accessing Polysubstituted NH Pyrroles from Nitroalkenes via [4+2]‐Cycloaddition/Reductive Ring Contraction Strategy DOI
Evgeny V. Pospelov,

Alexander V. Zhirov,

Baglan Kamidolla

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(30)

Published: June 17, 2024

Abstract A novel two‐step access to polysubstituted pyrroles from nitroalkenes was developed. It involves [4+2]‐cycloaddition with enol ethers give six‐membered cyclic nitronates followed by reductive ring contraction Ra−Ni/AcOH or Ra−Ni/EtOH systems. The process is applicable a variety of and bearing electron‐rich electron‐poor substituents functional groups. anti‐inflammatory drug Bimetopyrol its structural modifications were successfully synthesized the strategy key side products identified that provided an insight into mechanism developed pyrroles.

Language: Английский

Electrophilic Intermediates in the Nef and Meyer Reactions: A Computational Study DOI
Roman S. Malykhin, Alexey Yu. Sukhorukov

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 7, 2024

The generation, interconversion, and reactivity of electrophilic species generated upon activation nitroalkanes with protic acids (the Nef Meyer reactions) were investigated by quantum-chemical calculations.

Language: Английский

Citations

1
Direct α,β-C–H Difunctionalization of Piperidines for the Construction of the N,O-Acetal Skeleton via 1,5-Hydride Transfer DOI
Yi Zhang, Jinqiang Kuang, Yongmin Ma

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(18), P. 13373 - 13385

Published: Sept. 5, 2024

Herein, we describe an unprecedented Lewis acid-catalyzed annulation of phenols with

Language: Английский

Citations

0
Editorial: Heterodienes in organic synthesis DOI Creative Commons
Alexey Yu. Sukhorukov

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: April 8, 2024

EDITORIAL article Front. Chem., 08 April 2024Sec. Organic Chemistry Volume 12 - 2024 | https://doi.org/10.3389/fchem.2024.1403024

Language: Английский

Citations

0
Accessing Polysubstituted NH Pyrroles from Nitroalkenes via [4+2]‐Cycloaddition/Reductive Ring Contraction Strategy DOI
Evgeny V. Pospelov,

Alexander V. Zhirov,

Baglan Kamidolla

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(30)

Published: June 17, 2024

Abstract A novel two‐step access to polysubstituted pyrroles from nitroalkenes was developed. It involves [4+2]‐cycloaddition with enol ethers give six‐membered cyclic nitronates followed by reductive ring contraction Ra−Ni/AcOH or Ra−Ni/EtOH systems. The process is applicable a variety of and bearing electron‐rich electron‐poor substituents functional groups. anti‐inflammatory drug Bimetopyrol its structural modifications were successfully synthesized the strategy key side products identified that provided an insight into mechanism developed pyrroles.

Language: Английский

Citations

0