Cu‐Catalyzed Coupling of Sulfonyl Chlorides with Alkenes: Synthesis of Dienyl Sulfones and β‐Chlorosulfones

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract This work reports a Cu‐catalyzed coupling technique for synthesizing ( E )‐dienyl sulfones and β‐chlorosulfones from 1‐arylbutadienes styrenes, respectively. By employing easily available inexpensive reagents, this method enables the synthesis of diverse array dienyl with excellent functional group tolerance under base‐ oxidant‐free conditions. It also proves versatile late‐stage functionalization drug molecules scale‐up reactions. The showcases notable selectivity, gentle reaction conditions, compatibility various groups as demonstrated through 66 examples display regioselectivity.

Language: Английский

Visible-Light-Driven Synthesis of Alkenyl Thiocyanates: Novel Building Blocks for Diverse Sulfur-Containing Molecular Assembly

Chemical Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

A new photochemical method to prepare alkenyl thioethers under both batch and continuous flow conditions is presented. These versatile building blocks enable the synthesis of various organosulfur compounds, highlighting utility this procedure.

Language: Английский