Copper-Catalyzed Regioselective 1,4-Sulfonyl Indolylation of 1,3-Dienes with Sulfonyl Chloride and Indoles

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

A copper-based catalytic system has been described to enable the efficient 1,4-sulfonylindolylation of 1,3-dienes with sulfonyl chloride and indoles. This protocol offers a practical method for synthesis allylsulfone-containing indole derivatives broad range compatible functionalities excellent chemo- regioselectivities. Mechanistic studies suggest that copper catalyst plays dual role initiating radicals prompting coupling in this conjugated diene-selective 1,4-difunctionalization strategy.

Language: Английский

Palladium-catalyzed 1,2-selective intermolecular arylamination of 1,3-dienes

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

This method provides an effective means for the 1,2-selective arylamination of 1,3-dienes, demonstrating a wide substrate scope and excellent functional group tolerance solving problem poor selectivity in dienes.

Language: Английский