Ruthenium and Iodine Anion Cocatalyzed Cascade Dihalogenation and Cyclization of Internal Alkyne-Tethered Cyclohexadienones with 1,2-Dihaloethanes DOI
Xiaoli Huang, Yi Cui,

Meiqi Bai

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(13), P. 9686 - 9694

Published: June 22, 2024

We have established an efficient ruthenium(II) and iodine anion cocatalyzed dihalogenation cascade cyclization of internal alkyne-tethered cyclohexadienones, which stereoselectively afforded numerous products with a bioactive hydrobenzofuran skeleton in high yields under mild conditions. In this transformation, the reaction pathway was determined by concentration electrophilic reagent, also provided strategy for control selectivity. Furthermore, method features use 1,2-dihaloroethane as halogen source via catalyst.

Language: Английский

Ruthenium and Iodine Anion Cocatalyzed Cascade Dihalogenation and Cyclization of Internal Alkyne-Tethered Cyclohexadienones with 1,2-Dihaloethanes DOI
Xiaoli Huang, Yi Cui,

Meiqi Bai

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(13), P. 9686 - 9694

Published: June 22, 2024

We have established an efficient ruthenium(II) and iodine anion cocatalyzed dihalogenation cascade cyclization of internal alkyne-tethered cyclohexadienones, which stereoselectively afforded numerous products with a bioactive hydrobenzofuran skeleton in high yields under mild conditions. In this transformation, the reaction pathway was determined by concentration electrophilic reagent, also provided strategy for control selectivity. Furthermore, method features use 1,2-dihaloroethane as halogen source via catalyst.

Language: Английский

Citations

1