Recent Advancement in the Conversion of 1,2,3‐Benzotriazin‐4(3H)‐One to Other Heterocyclic Systems and Their Applications: A Concise Review

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(5)

Published: Feb. 1, 2025

Abstract The nitrogen containing 1,2,3‐benzotriazin‐4(3 H )‐one is structurally worthwhile system for its notable applications in the synthesis of N─ , O ─ and S─ heterocycles bears pivotal significant usage pharmaceutical industrial chemicals. Today most common items like dyes, cosmetics, sanitizers, insecticides plastics are based on heterocyclic moieties. Different starting materials used industrially formation diverse but a valuable structure to prepare numerous products. These conversions radiation or metal‐catalyzed denitrogenation annulation type reactions provide easy, one‐step atom‐economical route. vast significance their cheap make this subject interesting scientific researchers industrialists. This mini review summarizes recent developments transformation ring various other structures phenanthridinones, isoquinolones, coumarin‐1‐imines, benzamides, pyrroloquinazolinones, indolin‐1‐ones, 1,2‐benzisoselenazol‐3(2 )‐ones benzofuranones. Some emerging drugs ebselen, losartan, irbesartan, luotonin A, deoxyvasicinone mackinazolinone have been successfully synthesized from differently substituted benzotriazinones.

Language: Английский

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Recent advances in synthesis and transformations of 1,2,3-benzotriazinones

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1013, P. 123156 - 123156

Published: April 25, 2024

Language: Английский

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Controllable Molecular Editing of 2-Amino-N-substituted Benzamides: Site-selective Synthesis of 6-Selenylated N-Substituted 1,2,3-Benzotriazine-4(3H)-ones

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

We present an efficient silver-catalyzed one-pot controllable molecular editing protocol for the transformation of 2-amino-N-substituted benzamides into 6-selenylated N-substituted 1,2,3-benzotriazine-4(3H)-ones under mild reaction conditions. This three-component strategy is achieved by building N-N/N═N/C-Se bonds, which provides a practical pathway preparation selenylated with broad substrate scope and good functional group tolerance, as well high site-selectivity. Mechanistic experiments suggest that this proceeds via intermolecular site-selective C-H selenylation readily available diselenides, followed annulation using AgNO3 nitrogen synthon.

Language: Английский

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17.2.1.10 1,2,3-Triazines (Update 2025)

Published: Jan. 1, 2025

Abstract 1,2,3-Triazines, also sometimes known as v-triazines, are characterized by three contiguous nitrogen atoms in the six-membered ring. Benzo[1,2,3]triazines and heteroarene-fused 1,2,3-triazine derivatives have found applications drug development(tulrampator). The reactions of with primary amines, secondary thiols make them useful labeling molecules within biological systems. This update covers synthetic methods for preparation 1,2,3-triazines published between 2013 to 2024.

Language: Английский

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Norrish-Type Photocyclization of Aryl Triazines in Flow

Synfacts, Journal Year: 2024, Volume and Issue: 20(06), P. 0669 - 0669

Published: May 14, 2024

Language: Английский

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Direct Photochemical Synthesis of Substituted Benzo[b]fluorenes

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 24, 2024

We report a new and straightforward route toward substituted benzo[

Language: Английский

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