Recent Advances in Asymmetric Synthesis of Chiral-at-Sulfur Sulfoximines

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 5511 - 5530

Published: March 19, 2025

Language: Английский

Chiral Brønsted Acid-Catalyzed Kinetic Resolution of Sulfoximines for the Synthesis of Benzothiadiazine-1-Oxides

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(11), P. 7970 - 7981

Published: May 24, 2024

Benzothiadiazine-1-oxide scaffolds with S-stereogenic centers are prevalent in bioactive and pharmaceutical molecules. Reported works mainly focused on the metal-catalyzed asymmetric C–H amination/cyclization reaction for synthesis of benzothiadiazine-1-oxides. Here, we reported a chiral phosphoric acid-catalyzed kinetic resolution sulfoximines, providing benzothiadiazine-1-oxides recovered sulfoximines moderate to good enantioselectivities (s factors up 36.6).

Language: Английский

S-Alkylation of sulfinamides with Zn-carbenoids: expanding stereoselective sulfoximine synthesis beyond NH derivatives

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

A general entry to enantiopure N -substituted sulfoximines via direct stereospecific S -alkylation of sulfinamides with Zn-carbenoids is disclosed.

Language: Английский