Photoinduced Dearomative Multiple Functionalization of Quinolines to Construct Highly Substituted 3D Frameworks
Yuki Nagashima,
No information about this author
Asuha Shimose
No information about this author
Synlett,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Dearomative
functionalization
of
quinolines
expands
the
chemical
diversity
highly
functionalized
3D
frameworks,
such
as
1,2,3,4-
and
5,6,7,8-tetrahydroquinoline
derivatives,
which
are
important
pharmacophores,
with
minimal
synthetic
costs.
In
this
short
review,
we
cover
recent
reports
on
visible-light-induced
dearomative
an
emphasis
reaction
design/strategies
mechanistic
studies
provide
a
theoretical
basis
for
developing
further
syntheses
in
future.
1
Introduction
2
Functionalizations
through
Formation
Photoexcited
Quinolines
3
Reagents/Intermediates
4
Conclusion
Language: Английский
Development of organic photoreactions utilizing the characteristics of elements with low electronegativity
Bulletin of the Chemical Society of Japan,
Journal Year:
2024,
Volume and Issue:
97(8)
Published: July 31, 2024
Abstract
Organic
photoreactions
have
received
much
attention
as
unique
tools
to
access
kinetically
and/or
thermodynamically
prohibited
products
in
the
ground
state.
These
been
based
mainly
on
using
elements
with
high
electronegativity
such
carbon
(C),
oxygen
(O),
nitrogen
(N),
halogens
(F,
Cl,
Br,
and
I)
well
transition
metals.
On
other
hand,
we
interested
characteristics
of
low
electronegativity,
boron
(B),
silicon
(Si),
tin
(Sn),
excited
state,
enabling
highly
reactive
selective
photoinduced
borylations,
silylations,
stannylations.
In
this
account,
highlight
our
latest
findings
concerning
diverse
organic
utilizing
B,
Si,
Sn
elements,
which
are
challenging
when
conventional
strategies.
Language: Английский
Photocatalytic Generation of Germyl Radicals from Digermanes Enabling the Hydro/Deuteriogermylation of Alkenes
Haruka Iimuro,
No information about this author
Shiho Ishigaki,
No information about this author
Antônio Junio Araujo Dias
No information about this author
et al.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(21), P. 15623 - 15629
Published: Oct. 9, 2024
We
have
developed
a
visible-light-induced
method
to
photolyze
digermanes
through
single-electron
oxidation
using
photocatalyst,
in
contrast
direct
excitation,
generate
germyl
radicals
and
achieve
the
hydro/deuteriogermylation
of
alkenes.
This
protocol
allows
previously
elusive
incorporation
small
trimethylgermyl
group
deuterium,
metabolically
stable
bioisosteres
tert-butyl
hydrogen,
respectively,
making
this
approach
attractive
not
only
organic
synthesis
but
also
medicinal
chemistry.
Language: Английский