Electrochemical Desaturation and β-Thiocyanation of Cyclic Amides DOI

Kaili Miao,

Jin Zhang, Jiaxin Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis valuable molecules. We report herein electrochemical desaturation and β-thiocyanation under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions can be applied late-stage bioactive Mechanistic studies indicate that enamide intermediate might involved.

Language: Английский

Electrochemical 1,5-chlorosulfonylation and 1,5-hydrosulfonylation of vinylcyclopropanes DOI
Xin Zhang, Wei Li,

Yuxiang Zhou

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(19), P. 5564 - 5572

Published: Jan. 1, 2024

This study reports the electrochemical reaction of vinylcyclopropanes with sulfonyl chlorides, resulting in 1,5-hydrosulfonylation and 1,5-chlorosulfonylation.

Language: Английский

Citations

1
Photocatalytic and Electrocatalytic α-C–H Functionalization of Tertiary Amines DOI
Yumeng Liu,

Xiaojian Li,

Jiahong Li

et al.

Tetrahedron, Journal Year: 2024, Volume and Issue: 166, P. 134234 - 134234

Published: Aug. 31, 2024

Language: Английский

Citations

0
Non-Kolbe Oxidation Driven Electrochemical C(sp2)-H Lactonization towards the Synthesis of Isocoumarins DOI
Chen Liu, Hongpeng Liu,

Gaoyuan Zhang

et al.

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(23), P. 6742 - 6747

Published: Jan. 1, 2024

A novel method for electrochemical C(sp 2 )–H lactonization was developed.

Language: Английский

Citations

0
Recent Progress in the Synthesis of Benzoxazin-4-Ones, Applications in N-Directed Ortho-Functionalizations, and Biological Significance DOI Creative Commons
Ziad Moussa, Mani Ramanathan, Harbi Tomah Al‐Masri

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5710 - 5710

Published: Dec. 3, 2024

The development of efficient synthetic procedures to access fused N, O-heterocyclic skeletons has been a pivotal research topic in organic synthesis for several years. Owing the applications O-fused heterocycles synthesis, material sciences, and medicinal chemistry, significant efforts have dedicated design novel methods their construction. To this end, 1,3-benzoxazin-4-ones are privileged candidates molecules often found natural products, agrochemicals, materials science applications. In review, we aim summarize existing literature on from 2010 onwards. Moreover, also identified as an excellent native directing group ortho-functionalization via C-H activation, which is strenuous task requiring pre-functionalized substrates. latter part report, compiled interesting examples

Language: Английский

Citations

0
Pd-catalysed regioselective cross dehydrogenative coupling of quinazolinones with aromatic carboxylic acids DOI

Deepali S. Waghmare,

Priyanka M. Lagad,

Umesh A. Kshirsagar

et al.

Tetrahedron Letters, Journal Year: 2024, Volume and Issue: 147, P. 155214 - 155214

Published: July 23, 2024

Language: Английский

Citations

0
Construction of Isochromanones via Hemin-Catalyzed Phenol-Enamine Oxidative Annulation DOI
Muhammad Adnan Bashir, Tie Wang, Hui Guo

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(24), P. 18640 - 18648

Published: Nov. 26, 2024

We have developed a hemin-catalyzed biomimetic oxidative annulation of 2,3-dihydroxybenzoic acid with an array cyclic enamines to form isochromanones in good excellent yields and high regioselectivity. This formal [4+2] cycloaddition protocol showed efficiency remarkable functional group tolerance. Mechanistic studies indicate the involvement single-electron oxidation pathway. Preliminary biological investigations that 3ag 3ca exhibited antineoplastic activities against MCF-7 cell lines IC50 values 25.21 29.09 μM, respectively.

Language: Английский

Citations

0
Electrochemical Desaturation and β-Thiocyanation of Cyclic Amides DOI

Kaili Miao,

Jin Zhang, Jiaxin Chen

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

The site-selective functionalization of cyclic amides provides an attractive protocol for the synthesis valuable molecules. We report herein electrochemical desaturation and β-thiocyanation under external oxidant-free conditions. This method exhibits broad functional group tolerance, excellent selectivity, mild reaction conditions can be applied late-stage bioactive Mechanistic studies indicate that enamide intermediate might involved.

Language: Английский

Citations

0